-
1
-
-
0023176033
-
Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance
-
Blaser J, Stone BB, Groner MC et al. Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance. Antimicrob Agents Chemother 1987; 31: 1054-60.
-
(1987)
Antimicrob Agents Chemother
, vol.31
, pp. 1054-1060
-
-
Blaser, J.1
Stone, B.B.2
Groner, M.C.3
-
2
-
-
0025862429
-
Correlation between in vitro and in vivo activity of antimicrobial agents against gram-negative bacilli in a murine infection model
-
Fantin B, Leggett J, Ebert S et al. Correlation between in vitro and in vivo activity of antimicrobial agents against gram-negative bacilli in a murine infection model. Antimicrob Agents Chemother 1991; 35: 1413-22.
-
(1991)
Antimicrob Agents Chemother
, vol.35
, pp. 1413-1422
-
-
Fantin, B.1
Leggett, J.2
Ebert, S.3
-
3
-
-
0027457842
-
Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis
-
Drusano GL, Johnson DE, Rosen M et al. Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis. Antimicrob Agents Chemother 1993; 37: 483-90.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 483-490
-
-
Drusano, G.L.1
Johnson, D.E.2
Rosen, M.3
-
4
-
-
0027161344
-
Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients
-
Forrest A, Nix DE, Ballow CH et al. Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrob Agents Chemother 1993; 37: 1073-81.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 1073-1081
-
-
Forrest, A.1
Nix, D.E.2
Ballow, C.H.3
-
5
-
-
0029097440
-
Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins
-
Craig WA. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins. Diagn Microbiol Infect Dis 1995; 22: 89-96.
-
(1995)
Diagn Microbiol Infect Dis
, vol.22
, pp. 89-96
-
-
Craig, W.A.1
-
6
-
-
0036223185
-
The application of population pharmacokinetic modeling to individualized antibiotic therapy
-
Vinks AA. The application of population pharmacokinetic modeling to individualized antibiotic therapy. Int J Antimicrob Agents 2002; 19: 313-22.
-
(2002)
Int J Antimicrob Agents
, vol.19
, pp. 313-322
-
-
Vinks, A.A.1
-
7
-
-
0347063839
-
Impact of pharmacodynamics on breakpoint selection for susceptibility testing
-
Mouton JW. Impact of pharmacodynamics on breakpoint selection for susceptibility testing. Infect Dis Clin North Am 2003; 17: 579-98.
-
(2003)
Infect Dis Clin North Am
, vol.17
, pp. 579-598
-
-
Mouton, J.W.1
-
8
-
-
2142760947
-
Antimicrobial pharmacodynamics: Critical interactions of 'bug and drug'
-
Drusano GL. Antimicrobial pharmacodynamics: Critical interactions of 'bug and drug'. Nat Rev 2004; 2: 289-300.
-
(2004)
Nat Rev
, vol.2
, pp. 289-300
-
-
Drusano, G.L.1
-
9
-
-
62549152827
-
-
RxKinetics. antibiotic pk pd. http://www.rxkinetics.com/ antibiotic_pk_pd.html (16 December 2008, date last accessed).
-
RxKinetics. antibiotic pk pd. http://www.rxkinetics.com/ antibiotic_pk_pd.html (16 December 2008, date last accessed).
-
-
-
-
11
-
-
33644880121
-
Susceptibility testing of antimicrobials in liquid media
-
Lorian V, ed, Baltimore: Lippincott Williams & Wilkins
-
Amsterdam D. Susceptibility testing of antimicrobials in liquid media. In: Lorian V, ed. Antibiotics in Laboratory Medicine. Baltimore: Lippincott Williams & Wilkins, 2005; 61-144.
-
(2005)
Antibiotics in Laboratory Medicine
, pp. 61-144
-
-
Amsterdam, D.1
-
12
-
-
0001449983
-
Effect of growth rate of bacteria on action of penicillin
-
Hobby G, Dawson M. Effect of growth rate of bacteria on action of penicillin. Proc Soc Exp Biol 1944; 56: 181-4.
-
(1944)
Proc Soc Exp Biol
, vol.56
, pp. 181-184
-
-
Hobby, G.1
Dawson, M.2
-
13
-
-
0022652442
-
The rate of killing of Escherichia coli by beta-lactam antibiotics is strictly proportional to the rate of bacterial growth
-
Tuomanen E, Cozens R, Tosch W et al. The rate of killing of Escherichia coli by beta-lactam antibiotics is strictly proportional to the rate of bacterial growth. J Gen Microbiol 1986; 132: 1297-304.
-
(1986)
J Gen Microbiol
, vol.132
, pp. 1297-1304
-
-
Tuomanen, E.1
Cozens, R.2
Tosch, W.3
-
14
-
-
0025915346
-
Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria
-
Eng RH, Padberg FT, Smith SM et al. Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria. Antimicrob Agents Chemother 1991; 35: 1824-8.
-
(1991)
Antimicrob Agents Chemother
, vol.35
, pp. 1824-1828
-
-
Eng, R.H.1
Padberg, F.T.2
Smith, S.M.3
-
15
-
-
50349141358
-
Treatment of Staphylococcal infections with penicillin
-
Bigger J. Treatment of Staphylococcal infections with penicillin. Lancet 1944; 2: 497-500.
-
(1944)
Lancet
, vol.2
, pp. 497-500
-
-
Bigger, J.1
-
16
-
-
4644343922
-
Bacterial persistence as a phenotypic switch
-
Balaban NQ, Merrin J, Chait R et al. Bacterial persistence as a phenotypic switch. Science 2004; 305: 1622-5.
-
(2004)
Science
, vol.305
, pp. 1622-1625
-
-
Balaban, N.Q.1
Merrin, J.2
Chait, R.3
-
17
-
-
16244399491
-
Phenotypic tolerance: Antibiotic enrichment of noninherited resistance in bacterial populations
-
Wiuff C, Zappala RM, Regoes RR et al. Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations. Antimicrob Agents Chemother 2005; 49: 1483-94.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 1483-1494
-
-
Wiuff, C.1
Zappala, R.M.2
Regoes, R.R.3
-
18
-
-
0034002551
-
A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms
-
Brooun A, Liu S, Lewis K. A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother 2000; 44: 640-6.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 640-646
-
-
Brooun, A.1
Liu, S.2
Lewis, K.3
-
19
-
-
0028212019
-
Effect of antibiotics on non-growing planktonic cells and biofilms of Escherichia coli
-
Ashby MJ, Neale JE, Knott SJ et al. Effect of antibiotics on non-growing planktonic cells and biofilms of Escherichia coli. J Antimicrob Chemother 1994; 33: 443-52.
-
(1994)
J Antimicrob Chemother
, vol.33
, pp. 443-452
-
-
Ashby, M.J.1
Neale, J.E.2
Knott, S.J.3
-
20
-
-
0024991947
-
Influence of growth rate on susceptibility to antimicrobial agents: Biofilms, cell cycle, dormancy, and stringent response
-
Gilbert P, Collier PJ, Brown MR. Influence of growth rate on susceptibility to antimicrobial agents: Biofilms, cell cycle, dormancy, and stringent response. Antimicrob Agents Chemother 1990; 34 1865-8.
-
(1990)
Antimicrob Agents Chemother
, vol.34
, pp. 1865-1868
-
-
Gilbert, P.1
Collier, P.J.2
Brown, M.R.3
-
21
-
-
0024210157
-
Resistance of bacterial biofilms to antibiotics: A growth-rate related effect?
-
Brown MRW, Allison DG, Gilbert P. Resistance of bacterial biofilms to antibiotics: A growth-rate related effect? J Antimicrob Chemother 1988; 22: 777-80.
-
(1988)
J Antimicrob Chemother
, vol.22
, pp. 777-780
-
-
Brown, M.R.W.1
Allison, D.G.2
Gilbert, P.3
-
22
-
-
0035992362
-
Mechanisms of antibiotic resistance in bacterial biofilms
-
Stewart PS. Mechanisms of antibiotic resistance in bacterial biofilms. Int J Med Microbiol 2002; 292: 107-13.
-
(2002)
Int J Med Microbiol
, vol.292
, pp. 107-113
-
-
Stewart, P.S.1
-
23
-
-
10044266575
-
Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli
-
Keren I, Shah D, Spoering A et al. Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. J Bact 2004; 186: 8172-80.
-
(2004)
J Bact
, vol.186
, pp. 8172-8180
-
-
Keren, I.1
Shah, D.2
Spoering, A.3
-
24
-
-
0035077009
-
Riddle of biofilm resistance
-
Lewis K. Riddle of biofilm resistance. Antimicrob Agents Chemother 2001; 45: 999-1007.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 999-1007
-
-
Lewis, K.1
-
25
-
-
4644287346
-
Pharmacodynamic functions: A multiparameter approach to the design of antibiotic treatment regimens
-
Regoes RR, Wiuff C, Zappala RM et al. Pharmacodynamic functions: A multiparameter approach to the design of antibiotic treatment regimens. Antimicrob Agents Chemother 2004; 48: 3670-6.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3670-3676
-
-
Regoes, R.R.1
Wiuff, C.2
Zappala, R.M.3
-
26
-
-
33947505371
-
Antibiotic treatment in vitro of phenotypically tolerant bacterial populations
-
Wiuff C, Andersson DI. Antibiotic treatment in vitro of phenotypically tolerant bacterial populations. J Antimicrob Chemother 2007; 59 254-63.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 254-263
-
-
Wiuff, C.1
Andersson, D.I.2
-
27
-
-
0020528521
-
Influence of inoculum growth phase on microdilution susceptibility tests
-
Barry AL, Badal RE, Hawkinson RW. Influence of inoculum growth phase on microdilution susceptibility tests. J Clin Microbiol 1983; 18 645-51.
-
(1983)
J Clin Microbiol
, vol.18
, pp. 645-651
-
-
Barry, A.L.1
Badal, R.E.2
Hawkinson, R.W.3
-
28
-
-
0027154004
-
Post-antibiotic effects in experimental infection models: Relationship to in-vitro phenomena and to treatment of infections in man
-
Craig WA. Post-antibiotic effects in experimental infection models: relationship to in-vitro phenomena and to treatment of infections in man. J Antimicrob Chemother 1993; 31: 149-58.
-
(1993)
J Antimicrob Chemother
, vol.31
, pp. 149-158
-
-
Craig, W.A.1
-
29
-
-
0344936720
-
In vitro studies of pharmacodynamic properties of vancomycin against Staphylococcus aureus and Staphylococcus epidermidis
-
Lowdin E, Odenholt I, Cars O. In vitro studies of pharmacodynamic properties of vancomycin against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother 1998; 42 2739-44.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 2739-2744
-
-
Lowdin, E.1
Odenholt, I.2
Cars, O.3
-
30
-
-
13244281964
-
Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: The minimum inhibitory concentration versus stationary concentration
-
Mouton JW, Vinks AA. Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: The minimum inhibitory concentration versus stationary concentration. Clin Pharmacokinet 2005; 44: 201-10.
-
(2005)
Clin Pharmacokinet
, vol.44
, pp. 201-210
-
-
Mouton, J.W.1
Vinks, A.A.2
-
31
-
-
22244490051
-
Relationship between minimum inhibitory concentration and stationary concentration revisited: Growth rates and minimum bactericidal concentrations
-
Mouton JW, Vinks AA. Relationship between minimum inhibitory concentration and stationary concentration revisited: Growth rates and minimum bactericidal concentrations. Clin Pharmacokinet 2005; 44: 767-8.
-
(2005)
Clin Pharmacokinet
, vol.44
, pp. 767-768
-
-
Mouton, J.W.1
Vinks, A.A.2
-
32
-
-
0000466986
-
Experimental approach to the problem of treatment failure with penicillin
-
Eagle H. Experimental approach to the problem of treatment failure with penicillin. Am J Med 1952; 13: 389-99.
-
(1952)
Am J Med
, vol.13
, pp. 389-399
-
-
Eagle, H.1
-
33
-
-
0001580409
-
Microbial Persistence
-
McDermott W. Microbial Persistence. Yale J Biol Med 1958; 30 257-91
-
(1958)
Yale J Biol Med
, vol.30
, pp. 257-291
-
-
McDermott, W.1
-
34
-
-
33745189789
-
Non-inherited antibiotic resistance
-
Levin BR, Rozen DE. Non-inherited antibiotic resistance. Nat Rev 2006; 4: 556-62.
-
(2006)
Nat Rev
, vol.4
, pp. 556-562
-
-
Levin, B.R.1
Rozen, D.E.2
-
35
-
-
0014570943
-
Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin
-
Garrod LP, Waterworth PM. Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin. J Clin Pathol 1969; 22: 534-8.
-
(1969)
J Clin Pathol
, vol.22
, pp. 534-538
-
-
Garrod, L.P.1
Waterworth, P.M.2
-
36
-
-
0024387421
-
Effect of varying pH on the susceptibility of Campylobacter pylori to antimicrobial agents
-
Grayson M, Eliopoulos G, Ferraro M et al. Effect of varying pH on the susceptibility of Campylobacter pylori to antimicrobial agents. Eur J Clin Microbiol Infect Dis 1989; 8: 888-9.
-
(1989)
Eur J Clin Microbiol Infect Dis
, vol.8
, pp. 888-889
-
-
Grayson, M.1
Eliopoulos, G.2
Ferraro, M.3
-
37
-
-
33947507582
-
Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections
-
Baudoux P, Bles N, Lemaire S et al. Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections. J Antimicrob Chemother 2007: 59 246-53.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 246-253
-
-
Baudoux, P.1
Bles, N.2
Lemaire, S.3
-
38
-
-
0023789126
-
In vivo significance of the inoculum effect of antibiotics on Escherichia coli
-
Soriano F, Santamaria M, Ponte C et al. In vivo significance of the inoculum effect of antibiotics on Escherichia coli. Eur J Clin Microbiol Infect Dis 1988; 7: 410-2.
-
(1988)
Eur J Clin Microbiol Infect Dis
, vol.7
, pp. 410-412
-
-
Soriano, F.1
Santamaria, M.2
Ponte, C.3
-
39
-
-
0025324263
-
Relevance of the inoculum effect of antibiotics in the outcome of experimental infections caused by Escherichia coli
-
Soriano F, Ponte C, Santamaria M et al. Relevance of the inoculum effect of antibiotics in the outcome of experimental infections caused by Escherichia coli. J Antimicrob Chemother 1990; 25: 621-7.
-
(1990)
J Antimicrob Chemother
, vol.25
, pp. 621-627
-
-
Soriano, F.1
Ponte, C.2
Santamaria, M.3
-
40
-
-
0025669180
-
Killing and regrowth of bacteria in vitro: A review
-
Craig W, Ebert S. Killing and regrowth of bacteria in vitro: A review. Scand J Infect Dis Suppl 1990; 74: 63-70.
-
(1990)
Scand J Infect Dis Suppl
, vol.74
, pp. 63-70
-
-
Craig, W.1
Ebert, S.2
-
41
-
-
9644255765
-
Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model
-
LaPlante KL, Rybak MJ. Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model. Antimicrob Agents Chemother 2004; 48: 4665-72.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 4665-4672
-
-
LaPlante, K.L.1
Rybak, M.J.2
-
43
-
-
0026496574
-
General guidelines for clinical bacteriology. Infectious Diseases Society of America and the Food and Drug Administration
-
Thrupp LD, Cleeland R, Jones RN et al. General guidelines for clinical bacteriology. Infectious Diseases Society of America and the Food and Drug Administration. Clin Infect Dis 1992, 15 Suppl 1: S339-46.
-
(1992)
Clin Infect Dis
, vol.15
, Issue.SUPPL. 1
-
-
Thrupp, L.D.1
Cleeland, R.2
Jones, R.N.3
-
46
-
-
0347093260
-
Effects of inoculum and beta-lactamase activity in AmpC- and extended-spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using NCCLS ESBL methodology
-
Queenan AM, Foleno B, Gowilley C et al. Effects of inoculum and beta-lactamase activity in AmpC- and extended-spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using NCCLS ESBL methodology. J Clin Microbiol 2004; 42: 269-75.
-
(2004)
J Clin Microbiol
, vol.42
, pp. 269-275
-
-
Queenan, A.M.1
Foleno, B.2
Gowilley, C.3
-
48
-
-
0027230031
-
The post-antibiotic effect of antimicrobial combinations in a neutropenic murine thigh infection model
-
Gudmundeson S, Einarsson S, Erlendsdottir H et al. The post-antibiotic effect of antimicrobial combinations in a neutropenic murine thigh infection model. J Antimicrob Chemother 1993; 31 Suppl D: 177-91.
-
(1993)
J Antimicrob Chemother
, vol.31
, Issue.SUPPL. D
, pp. 177-191
-
-
Gudmundeson, S.1
Einarsson, S.2
Erlendsdottir, H.3
-
50
-
-
33644656768
-
Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages
-
Barcia-Macay M, Seral C, Mingeot-Leclercq M-P et al. Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages. Antimicrob Agents Chemother 2006; 50: 841-51.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 841-851
-
-
Barcia-Macay, M.1
Seral, C.2
Mingeot-Leclercq, M.-P.3
-
52
-
-
2642605303
-
Nalidixic acid and the metabolism of Escherichia coli
-
Winshell EB, Rosenkranz HS. Nalidixic acid and the metabolism of Escherichia coli. J Bact 1970; 104: 1168-75.
-
(1970)
J Bact
, vol.104
, pp. 1168-1175
-
-
Winshell, E.B.1
Rosenkranz, H.S.2
-
54
-
-
0025761199
-
The mode of action of quinolones: The paradox in activity of low and high concentrations and activity in the anaerobic environment
-
Lewin CS, Morrissey I, Smith JT. The mode of action of quinolones: The paradox in activity of low and high concentrations and activity in the anaerobic environment. Eur J Clin Microbiol Infect Dis 1991; 10 240-8.
-
(1991)
Eur J Clin Microbiol Infect Dis
, vol.10
, pp. 240-248
-
-
Lewin, C.S.1
Morrissey, I.2
Smith, J.T.3
-
56
-
-
0021213694
-
Mutational resistance to 4-quinolone antibacterial agents
-
Smith JT, Mutational resistance to 4-quinolone antibacterial agents. Eur J Clin Microbiol 1984; 3: 347-50.
-
(1984)
Eur J Clin Microbiol
, vol.3
, pp. 347-350
-
-
Smith, J.T.1
-
57
-
-
34548213103
-
A common mechanism of cellular death induced by bactericidal antibiotics
-
Kohanski MA, Dwyer DJ, Hayete B et al. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 2007: 130: 797-810.
-
(2007)
Cell
, vol.130
, pp. 797-810
-
-
Kohanski, M.A.1
Dwyer, D.J.2
Hayete, B.3
-
58
-
-
0031057479
-
The population dynamics of antimicrobial chemotherapy
-
Lipsitch M, Levin BR. The population dynamics of antimicrobial chemotherapy. Antimicrob Agents Chemother 1997; 41: 363-73.
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 363-373
-
-
Lipsitch, M.1
Levin, B.R.2
-
59
-
-
0033836018
-
Mutant prevention concentration as a measure of antibiotic potency: Studies with clinical isolates of Mycobacterium tuberculosis
-
Dong Y, Zhao X, Kreiswirth BN et al. Mutant prevention concentration as a measure of antibiotic potency: Studies with clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 2000; 44: 2581-4.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 2581-2584
-
-
Dong, Y.1
Zhao, X.2
Kreiswirth, B.N.3
-
60
-
-
0037083238
-
Restricting the selection of antibiotic-resistant mutant bacteria: Measurement and potential use of the mutant selection window
-
Zhao X, Drlica K. Restricting the selection of antibiotic-resistant mutant bacteria: Measurement and potential use of the mutant selection window. J Infect Dis 2002; 185: 561-5.
-
(2002)
J Infect Dis
, vol.185
, pp. 561-565
-
-
Zhao, X.1
Drlica, K.2
-
61
-
-
33847045214
-
Mutant selection window hypothesis updated
-
Drlica K, Zhao X. Mutant selection window hypothesis updated. Clin Infect Dis 2007; 44: 681-8.
-
(2007)
Clin Infect Dis
, vol.44
, pp. 681-688
-
-
Drlica, K.1
Zhao, X.2
-
62
-
-
0006683815
-
The bactericidal action of penicillin in vivo: The participation of the host, and the slow recovery of the surviving organisms
-
Eagle H, Fleischman R, Musselman A. The bactericidal action of penicillin in vivo: The participation of the host, and the slow recovery of the surviving organisms. Ann Intern Med 1950; 33: 544-71.
-
(1950)
Ann Intern Med
, vol.33
, pp. 544-571
-
-
Eagle, H.1
Fleischman, R.2
Musselman, A.3
-
63
-
-
0006782265
-
The effect of the size of the inoculum and the age of the infection on the curative dose of penicillin in experimental infections with streptococci, pneumococci, and Treponema pallidum
-
Eagle H. The effect of the size of the inoculum and the age of the infection on the curative dose of penicillin in experimental infections with streptococci, pneumococci, and Treponema pallidum. J Exp Med 1949; 90: 595-607.
-
(1949)
J Exp Med
, vol.90
, pp. 595-607
-
-
Eagle, H.1
-
64
-
-
33744527833
-
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
-
Kumar A, Roberts D, Wood KE et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34: 1589-96.
-
(2006)
Crit Care Med
, vol.34
, pp. 1589-1596
-
-
Kumar, A.1
Roberts, D.2
Wood, K.E.3
|