The G protein-coupled receptor FSHR-1 is required for the caenorhabditis elegans innate immune response

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 8, 2009, Pages 2782-2787

  Powell, Jennifer R ^a,b   Kim, Dennis H ^a,b   Ausubel, Frederick M ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Eucine rich repeat; Host pathogen interactions

Indexed keywords

FOLLITROPIN RECEPTOR; G PROTEIN COUPLED RECEPTOR; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE P38; SOMATOMEDIN;

CAENORHABDITIS ELEGANS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOST PATHOGEN INTERACTION; INNATE IMMUNITY; INTESTINE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CAENORHABDITIS ELEGANS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; IMMUNITY, INNATE; INSULIN; INTESTINES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, G-PROTEIN-COUPLED;

ANIMALIA; BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS; INVERTEBRATA; NEGIBACTERIA; POSIBACTERIA; VERTEBRATA;

EID: 62449145675     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0813048106     Document Type: Review

References (36)

1. Janeway CA, Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197-216.
2. Medzhitov R (2007) Recognition of microorganisms and activation of the immune response. Nature 449:819-826.
3. Schulenburg H, Kurz CL, Ewbank J J (2004) Evolution of the innate immune system: The worm perspective. Immunol Rev 198:36-58.
4. Sifri CD, Begun J, Ausubel FM (2005) The worm has turned-Microbial virulence modeled in Caenorhabditis elegans. Trends Microbiol 13:119-127.
5. Kim DH, Ausubel FM (2005) Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans. Curr Opin Immunol 17:4-10.
6. Kim DH, et al. (2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297:623-626.
7. Kim DH, et al. (2004) Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc Natl Acad Sci USA 101:10990-10994.
8. Liberati NT, et al. (2004) Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci USA 101:6593-6598.
9. Matsuzawa A, et al. (2005) ROS-dependent activation of theTRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6:587-592.
10. Garsin DA, et al. (2003) Long-lived C. elegans daf-2 mutants are resistantto bacterial pathogens. Science 300:1921.
11. Lin K, DormanJB, Rodan A, Kenyon C (1997) daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278:1319-1322.
12. Ogg S, et al. (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389:994-999.
13. Mallo GV, et al. (2002) Inducible antibacterial defense system in C. elegans. Curr Biol 12:1209-1214.
14. O'Rourke D, Baban D, Demidova M, Mott R, Hodgkin J (2006) Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. Genome Res 16:1005-1016.
15. Troemel ER, et al. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet 2(11):e183.
16. Wong D, Bazopoulou D, Pujol N, Tavernarakis N, Ewbank JJ (2007) Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol 8:R194.
17. Pujol N, et al. (2001) A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Curr Biol 11:809-821.
18. Tenor J L, Aballay A (2008) A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. EM BO Rep 9:103-109.
19. Kedzierski L, Montgomery J, Curtis J, Handman E (2004) Leucine-rich repeats in host-pathogen interactions. Arch Immunol Ther Exp (Warsz) 52:104-112.
20. Cho 5, Rogers KW, Fay DS (2007) The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Curr Biol 17:203-212.
21. Sieburth D, et al. (2005) Systematic analysis of genes required for synapse structure and function. Nature 436:510-517.
22. Miyata S, Begun J, Troemel ER, Ausubel FM (2008) DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics 178:903-918.
23. Fan QR, Hendrickson WA (2005) Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433:269-277.
24. Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987-995.
25. Kocks C, et al. (2005) Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell123:335-346.
26. Simoni M, Gromoll J, Nieschlag E (1997) The follicle-stimulating hormone receptor: Biochemistry, molecular biology, physiology, and pathophysiology. Endocr Rev 18:739-773.
27. Herath S, et al. (2007) Ovarian follicular cells have innate immune capabilities that modulate their endocrine function. Reproduction 134:683-693.
28. Sun L, et al. (2006) FSH directly regulates bone mass. Cell 125:247-260.
29. Takayanagi H (2007) Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7:292-304.
30. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
31. Fraser AG, et al. (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408:325-330.
32. Kamath RS, Ah ringer J (2003) Genome-wide RNAi screening in Caenorhabditis elegans. Methods 30:313-321.
33. Rual JF, et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 14:2162-2168.
34. Ahringer J, ed (2006) Reverse genetics. Available at: http://www.wormbook.org/chapters/wwwJntroreversegenetics/introreversegenetics. html. Accessed August 1, 2008.
35. Espelt MV, Estevez AY, Yin X, Strange K (2005) Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: Role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. J Gen Physiol 126:379-392.
36. Powell JR, Ausubel FM (2007) Models of Caenorhabditis elegans infection by bacterial and fungal pathogens. Innate Immunity, Methods in Molecular Biology, eds Ewbank J, Vivier E (Humana Press, Totowa, NJ), Vol 415, pp 403-427.