Pentobarbital Produces Activation and Block of α 1 β 2γ 2S GABA A receptors in rapidly perfused whole cells and membrane patches: Divergent results can be explained by pharmacokinetics

Journal of General Physiology

Volumn 133, Issue 2, 2009, Pages 171-188

  Gingrich, Kevin J ^a,b   Burkat, Paul M ^b,c   Roberts, William A ^b,d  

^a NEW YORK UNIVERSITY   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d Northwestern Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; PENTOBARBITAL; 4 AMINOBUTYRIC ACID; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; PROTEIN SUBUNIT;

ARTICLE; BINDING SITE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CHLORIDE CURRENT; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; LIPOPHILICITY; WHOLE CELL; ANIMAL; BIOLOGICAL MODEL; CHANNEL GATING; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEEDBACK SYSTEM; INTRACELLULAR SPACE; ION TRANSPORT; METABOLISM; METHODOLOGY; PATCH CLAMP; PHARMACOKINETICS; PHYSIOLOGY; RAT;

ANIMALS; BINDING SITES; CELL COMPARTMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDBACK, BIOCHEMICAL; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; HUMANS; INTRACELLULAR SPACE; ION CHANNEL GATING; ION TRANSPORT; MODELS, BIOLOGICAL; PATCH-CLAMP TECHNIQUES; PENTOBARBITAL; PHARMACOKINETICS; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; RESEARCH DESIGN;

EID: 62349122248     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.200810081     Document Type: Article

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