Acute and repeated dose toxicity studies of recombinant saxatilin, a disintegrin from the Korean snake (Gloydius saxatilis)

Toxicon

Volumn 51, Issue 3, 2008, Pages 406-417

  Sohn, Young Doug ^a   Hong, Sung Yu ^b   Cho, Kil Sang ^e   Choi, Won Seok ^c   Song, Si Whan ^d   Bae, Jin Sook ^d   Kim, Doo Sik ^c   Chung, Kwang Hoe ^e  

^a Yonsei University College of Medicine   (South Korea)

^b BioBud Inc   (South Korea)

^c Bioproducts Research Center   (South Korea)

^d Chemon Inc   (South Korea)

^e Department of Biochemistry   (South Korea)

Author keywords

Acute toxicity; Disintegrin; Mass production; Plasma half life; Repeated dose toxicity; Saxatilin

Indexed keywords

DISINTEGRIN; SAXATILIN; UNCLASSIFIED DRUG;

ACUTE TOXICITY; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; FEMALE; FERMENTATION; GLOYDIUS SAXATILIS; IC 50; LD 50; MALE; MOUSE; NONHUMAN; PLASMA HALF LIFE; PRIORITY JOURNAL; RAT; SNAKE; SPLEEN;

ANIMALS; DISINTEGRINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; GENE EXPRESSION REGULATION; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED ICR; ORGAN SIZE; ORGANISMS, GENETICALLY MODIFIED; PICHIA; PLATELET AGGREGATION; RECOMBINANT PROTEINS; SPLEEN; URINE; VIPERIDAE; WEIGHT LOSS;

GLOYDIUS SAXATILIS; MUS; PICHIA PASTORIS; RATTUS;

EID: 39149141580     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2007.10.019     Document Type: Article

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