Contortrostatin, a homodimeric snake venom disintegrin, is a potent inhibitor of osteoclast attachment

Journal of Bone and Mineral Research

Volumn 13, Issue 3, 1998, Pages 409-414

  Mercer, B ^a   Markland, F ^a   Minkin, C ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; DISINTEGRIN; SNAKE VENOM; VITRONECTIN;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CELL ADHESION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; MOLECULAR INTERACTION; NONHUMAN; OSTEOCLAST; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BONE RESORPTION; CATTLE; CELL ADHESION; CROTALID VENOMS; DISINTEGRINS; EXTRACELLULAR MATRIX; FETAL BLOOD; INTEGRIN BETA3; OLIGOPEPTIDES; OSTEOCLASTS; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VITRONECTIN; VITRONECTIN;

EID: 0031897532     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.3.409     Document Type: Article

References (21)

1. Sato M, Garsky V, Majeska RJ, Einhorn TA, Murray J, Tashjian AH, Gould RJ 1994 Structure-activity studies of the s-Echistatin inhibition of bone resorption. J Bone Miner Res 9:1441-1449.
2. King KL, Danza JJ, Bodary S, Pitti R, Siegel M, Lazarus RA, Dennis MS, Hammonds RG, Kukreja SC 1992 Effects of Kistrin on bone-resorption in-vitro and serum calcium in-vivo. J Bone Miner Res 9:381-387.
3. Sato M, Sardana MK, Grasser WA, Garsky VM, Murray JM, Gould RJ 1990 Echistatin is a potent inhibitor of bone resorption in culture. J Cell Biol 111:1713-1723.
4. Ruoslahti E, Pierschbacher MD 1987 New perspectives in cell adhesion: RGD and integrins. Science 238:491-497.
5. Pytela R, Pierschbacher MD, Ruoslahti E 1985 A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin. Proc Natl Acad Sci USA 82:5766-5770.
6. Haynes RO 1987 Integrins: A family of cell surface receptors. Cell 48:549-554.
7. Ruoslahti E 1991 Integrins. J Clin Invest 87:1-5.
8. Horton MA, Davies J 1989 Perspectives: Adhesion receptors in bone. J Bone Miner Res 4:803-808.
9. Hultenby K. Reinholt FP, Heinegard D 1993 Distribution of integrin subunits on rat metaphyseal osteoclasts and osteoblasts. Eur J Cell Biol 62:86-93.
10. Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M 1989 The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 109:1817-1826.
11. 3 integrin. J Bone Miner Res 7:335-343.
12. Horton MA, Dorey EL, Nesbitt SA, Samanen J, Ali FE, Stader JM, Nichol A, Greg R, Helfrich M 1993 Modulation of vitronectin receptor-mediated osteoclast adhesion by Arg-Gly-Asp peptide analogs: A structure-function analysis. J Bone Miner Res 8:239-247.
13. Clark A, Trikha M, Markland FS, Brugge J 1994 Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation. J Biol Chem 269:21940-21943.
14. Trikha M, Rote WE, Manley PJ, Lucchesi BR, Markland FS 1994 Purification and characterization of platelet aggregation inhibitors from snake venoms. Thrombosis Res 73:39-52.
15. Williams JA 1992 Disintegrins: RGD-containing proteins which inhibit cell/matrix interactions (adhesion) and cell/cell interactions (aggregation) via their integrin receptors. Path Biol 40:813-821.
16. Niewiarowski S, McLane MA, Kloczewiak M, Stewart GJ 1994 Disintegrins and other naturally occuring antagonists of platelet fibrinogen receptors. Semin Hematol 31:289-300.
17. Dennis MS, Henzel W, Pitti RM, Lipari MT, Napier MA, Deisher TA, Bunting S, Lazarus RA 1989 Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: Evidence for a family of platelet-aggregation inhibitors. Proc Natl Acad Sci USA 87:2471-2475.
18. 1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis. Cancer Res 54:4993-4998.
19. Mendrick DL, Kelly DM 1993 Temporal expression of VLA-2 and modulation of its ligand specificity by rat glomerular epithelial cells in vitro. Lab Invest 69:690-702.
20. Miyauchi A, Alvarez J, Greenfield EM, Teti A, Grano M 1991 Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts. J Biol Chem 266:20369-20374.
21. 3 integrin. J Bone Miner Res 7:345-351.