Effects of α-lipoic acid administration on plasma glucose levels, total malondialdehyde values and withdrawal signs in rats treated with morphine or morphine plus naloxone

Arzneimittel-Forschung/Drug Research

Volumn 59, Issue 2, 2009, Pages 72-78

  Pinelli, Arnaldo ^a,b   Cighetti, Giuliana ^a   Trivulzio, Silvio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Department of Pharmacology ^*  (Italy)

Author keywords

CAS 1077 28 7; CAS 51481 60 8; CAS 57 27 2; Morphine; Naloxone; lipoic add, effect on morphine withdrawal signs, plasma glucose levels, plasma total malondialdehyde, reactive oxygen species

Indexed keywords

GLUCOSE; MALONALDEHYDE; MORPHINE; NALOXONE; PEROXIDE; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEFECATION; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; JUMPING; LATENT PERIOD; MALE; NONHUMAN; PAIN THRESHOLD; RAT; WITHDRAWAL SYNDROME;

EID: 62249111385     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296367     Document Type: Article

References (51)

1. Borison HL, Fishburn BR, Bhide NK, McCarthy LE. Morphine-induced hyperglycemia in the cat. J Pharm Exp Ther. 1962;138:229-35.
2. Radosevich PM, Williams PE, Lacy DB, McRae JR, Steiner KE, Cherrington AD, Lacy WW, Abumrad NN. Effects of morphine on glucose homeostasis in the conscious dog. J Clin Invest. 1984;74:1473-80.
3. Johansen O, Tonnesen T, Jensen T, Jorde R, Burhol PG, Reikeras O. Increments in glucose, glucagon and insulin after morphine in rats, and naloxone blocking of this effect. Life Sci. 1992;51:1237-42.
4. Piconi L, Quagliaro L, Ceriello A. Oxidative stress in diabetes. Clin Chem Lab Med. 2003;41:1144-9.
5. Sharp BM, Keane WF, Suh HJ, Gekker G, Tsukayama D, Peterson PK. Opioid peptides rapidly stimulate superoxide production by human polymorphonuclear leukocytes and macrophages. Endocrinology. 1985;117:793-5.
6. Singhal PC, Pamarthi M, Shah R, Chandra D., Gibbons N. Morphine stimulates superoxide formation by glomerular mesanglial cells. Inflammation. 1994;18:293-299.
7. William S, Sekar N, Subramanian S, Govindasamy S. Toxic effect of morphine and the antagonistic role of naloxone on isolated rat hepatocytes. Biochem International. 1991;23:1071-7.
8. Zhang YT, Zheng QS, Pan J, Zheng RL. Oxidative damage of biomolecules in mouse liver induced by morphine and protected by antioxidants. Basic Clin Pharm Toxicol. 2004;95:53-8.
9. Pan J, Zhang Q, Zhang Y, Ouyang Z, Zheng Q, Zheng R. Oxidative stress in heroin administered mice and natural antioxidants protection. Life Sci. 2005;77:183-93.
10. Xu B, Wang Z, Li G, Li B, Lin H, Zheng R, Zheng Q. Heroin- administered mice involved in oxidative stress and exogenous antioxidant-alleviated withdrawal syndrome. Basic Clin Pharmacol Toxicol. 2006;99:153-61.
11. Pinelli A, Trivulzio S. Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine. J Pharmacol Toxicol Methods. 1997;38:117-31.
12. Pasquinelli, F. Diagnostica e tecniche di laboratorio. Firen- ze: Rosini; 1997.
13. Cighetti G, Debiasi S, Paroni R, Allevi P. Free and total malondialdehyde assessment in biological matrices by gas chromatography-mass spectrometry: what is needed for an accurate detection. Anal Biochem. 1999;266:222-9.
14. Estrada DE, Ewart HS, Tsakiridis T, Volchuk A, Ramlal T, Tritschler H, Klip A. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes. 1996;45:1798-804.
15. Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997;29:315-31.
16. Pinelli A, Trivulzio S, Tomasoni L. Effects of administration of phentonium bromide on opioid withdrawal syndrome in rats. J Pharm Pharmacol. 1997;49:1222-8.
17. Pinelli A, Trivulzio S, Vignati S. Effects exerted by otilonium bromide administration on precipitated opioid withdrawal syndrome in rats. Toxicology. 1997;122:23-37.
18. Harris LS, Dewey WL, Howes IF, Kennedy IS, Pars H. Narcotic antagonist analgesics: interactions with cholinergic systems. J Pharm Exp Ther. 1969;169:17-22.
19. Armitage P. Statistica Medica. 10th ed. Milan (Italy): Feltrinelli; 1991.
20. Borrell J, Llorens I, Borrell S. Adrenal, plasma and urinary corticosteroids during single or repeated administration of morphine in cats. Eur J Pharmacol. 1975;31:237-42.
21. Chan MY, Dai S. Effects of acute and chronic morphine administration on glucose tolerance in mice. Pharmacology. 1987;34:233-40.
22. Kimes AS, London ED, Glucose utilization in the rat brain during chronic morphine treatment and naloxone-precipi- tated morphine withdrawal. J Pharm Exp Ther. 1989;248:538-45.
23. nd, Wooten GF. Similar functional anatomy of spontaneous and precipitated morphine withdrawal. Brain Res. 1985;334:183-6.
24. Adams RE, Wooten GF. Dependence and withdrawal following intracerebroventricular and systemic morphine administration: functional anatomy and behavior. Brain Res. 1990;518:6-10.
25. Bloch-Damti A, Bashan N, Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxidants Redox Signaling. 2005;7:1553-67.
26. Ramrath S, Tritschler HJ, Eckel J. Stimulation of cardiac glucose transport by thioctic acid and insulin. Horm Metab Res. 1999;31:632-5.
27. Baumann J, Wurm G. Studies on the possible involvement of singlet oxygen and superoxide anion radicals in the cyclo-oxygenase reaction. Prostaglandins Leukot Med. 1984;14:139-52.
28. Trang T, Sutak M, Quirion R, Jhamandas K. The role of spinal neuropeptides and prostaglandins in opioid physical dependence. Br J Pharmacol. 2002;136:37-48.
29. Trang T, McNaull B, Quirion R, Jhamandas K. Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance. Eur J Pharmacol. 2004;491:21-30.
30. Ha H, Lee JH, Kim HN, Kim HM, Kwak HB, Lee S, Kim HH, Lee ZH. alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis. J Immunol. 2006;176:111-7.
31. Lapenna D, Ciofani G, Pierdomenico SD, Giamberardino MA, Cuccurullo F. Dihydrolipoic acid inhibits 15-lipoxy- genase-dependent lipid peroxidation. Free Rad Biol Med. 2003;35:1203-9.
32. Dunbar SA, Karamov IG, Buerkle H. The effect of spinal ibuprofen on opioid withdrawal in the rat. Anesth Analg. 2000;91:417-22.
33. Wong CL, Roberts MB, Wai MK. Effect of morphine and naloxone on intestinal transit in mice. Eur J Pharmacol. 1980;64:289-95.
34. Beubler E, Bukhave K, Rask-Madsen J. Colonic secretion mediated by prostaglandin E2 and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat. Gastroenterol. 1984;87:1042-8.
35. Coupar IM, Hardcastle J, Hardcastle PT. The response of the intestinal mucosa to prostaglandin E2 during withdrawal from morphine. J Pharm Pharmacol. 1988;40:262-6.
36. Capasso A. Further studies on the involvement of the ara- chidonic acid cascade in the acute dependence produced by mu, kappa and delta opioid agonists in isolated tissues. Neuropharmacology. 1999;38:871-7.
37. Capasso A, Sorrentino L. Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum. Eur J Pharmacol. 1997;330:199-204.
38. Enrico P, Esposito G, Mura MA, Fresu L, De Natale G, Miele E, Desole MS, Miele M. Effect of morphine on striatal dopamine metabolism and ascorbic and uric acid release in freely moving rats. Brain Res. 1997;745:173-82.
39. Lal H. Narcotic dependence, narcotic action and dopamine receptors. Life Sci. 1975;17:483-95.
40. Enrico P, Esposito G, Mura MA, Migheli R, Serra PA, Desole MS, Miele E, De Natale G, Miele M. Effects of allopurinol on striatal dopamine, ascorbate and uric acid during an acute morphine challenge: ex vivo and in vivo studies. Pharmacological Res. 1997;35:577-85.
41. Bilska A, Dubiel M, Sokolowska-Jezewicz M, Lorenc-Koci E, Wlodek L. Alpha-lipoic acid differently affects the reser- pine-induced oxidative stress in the striatum and prefrontal cortex of rat brain. Neuroscience. 2007;146:1758-71.
42. Mori T, Ito S, Matsubayashi K, Sawaguchi T. Comparison of nitric oxide synthase inhibitors, phospholipase A2 inhibitor and free radical scavengers as attenuators of opioid withdrawal syndrome. Behavioural Pharmacol. 2007;18:725-9.
43. Jameel NM, Shekhar MA, Vishwanath BS. Alpha-lipoic acid: an inhibitor of secretory phospholipase A2 with antiinflammatory activity. Life Sci. 2006;80:146-53.
44. Johnston PA, Chahl LA, Chronic treatment with ascorbic acid inhibits the morphine withdrawal response in guinea-pigs. Neuroscience Lett. 1992;135:23-27.
45. Khanna NC, Sharma SK. Megadoses of vitamin C prevent the development of tolerance and physical dependence on morphine in mice. Life Sci. 1983;33 Suppl 1:401-4.
46. Evangelou A, Kalfakakou V, Georgakas P, Koutras V, Vezy- raki P, Iliopoulou L, Vadalouka A. Ascorbic acid (vitamin C) effects on withdrawal syndrome of heroin abusers. In Vivo 2000;14:363-6.
47. Ceriello A, Giugliano D, Passariello N, Quatraro A, Dello Russo P, Torella R, D'Onofrio F. Impaired glucose metabolism in heroin and methadone users. Horm Metab Res. 1987;19:430-3.
48. Diaz-Flores Estevez JF, Diaz-Flores Estevez F, Hernandez Calzadilla C, Rodriguez Rodriguez EM, Diaz Romero C, Serra-Majem L. Application of linear discriminant analysis to the biochemical and haematological differentiation of opiate addicts from healthy subjects: a case-control study. Eur J Clin Nutr. 2004;58:449-55.
49. Panchenko LF, Pirozhkov SV, Nadezhdin AV, Baronets Vlu, Usmanova NN. [Lipid peroxidation, peroxyl radical- scavenging system of plasma and liver and heart pathology in adolescence heroin users], Voprosy Meditsinskoi Khimii 1999;45:501-6.
50. Zhou JF, Yan XF, Ruan ZR, Peng FY, Cai D, Yuan H, Sun L, Ding DY, Xu SS. Heroin abuse and nitric oxide, oxidation, peroxidation, lipoperoxidation. Biomed Environm Sci. 2000;13:131-9.
51. Nelson DL, Cox MM. in Lehninger. Principle of Biochemistry. 4th ed. New York: Freeman W. Company; 2005. p. 602-10.