Effects of administration of phentonium bromide on opioid withdrawal syndrome in rats

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 12, 1997, Pages 1222-1228

  Pinelli, A ^a,b   Trivulzio, S ^a   Tomasoni, L ^a  

^a Chemother Med T   (Italy)

^b Department of Pharmacology ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FENTONIUM BROMIDE; MORPHINE; MUSCARINIC RECEPTOR BLOCKING AGENT; NALOXONE; OPIATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEFECATION; DRUG MECHANISM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICTURITION; NOCICEPTION; NONHUMAN; RAT; SALIVATION; WET DOG SHAKES; WITHDRAWAL SYNDROME;

EID: 0031453202     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06074.x     Document Type: Article

References (29)

1. Armitage, P. (1991) Statistica Medica X Edizione. Feltrinelli, Milano, pp 296-339; 382-394; 402-412
2. Azzolini, F., Borgia, M., Frigerio, G., Lodola, E., Monafo, V., Porsio, A. (1970) Human pharmacology of phentonium, a new autonomic drug. Curr. Ther. Res. 12: 734-754
3. Benelli, G., Santini, V. (1974) Analysis of the action of some substances on the visceral nerve endings. Bull. Chim. Pharm. 113: 291-298
4. Bhargava, H. N. (1994) Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome and self-administrative behaviour. Pharmacol. Rev. 46: 293-324
5. Bhargava, H. N., Way, E. L. (1972) Acetylcholinesterase inhibition and morphine effects in morphine tolerant and dependent mice. J. Pharmacol. Exp. Ther. 183: 31-40
6. Bianchi, G., Fiocchi, R., Tavani, A., Manara, L. (1982) Quaternary narcotic antagonists relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine treated rats as an index of peripheral selectivity. Life Sci. 30: 1875-1883
7. Brase, D. A., Tseng, L. F., Loh, H. H., Way, E. L. (1974) Cholinergic modification of naloxone-induced jumping in morphine dependent mice. Eur. J. Pharmacol. 26: 1-8
8. Brown, J. H., Taylor, P. (1995) Muscarinic receptor agonists and antagonists. In: Hardman, J. G., Limbird, L. E., Molinoff, P. B., Ruddon, R. W., Goodman Gilman, A. (eds) The Pharmacological Basis of Therapeutics. IX Edition, McGraw-Hill Company, New York, pp 141-160
9. Collier, H. O., Francis, D. L., Schneider, C. (1972) Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretations. Nature 237: 220-223
10. Cowan, D. A. (1993) Effects of opioids on the spontaneous behaviour of animals. In: Herz, A., Akil, H., Simon, E. J. (eds) Opioids. Vol. II, Springer, Berlin, pp 393-428
11. Della Bella, D., Gandini, A., Teotino, O. M. (1968) Propriétés pharmacologiques de nouveaux derivés quaternaires de l'atropine et de la hyoscyamine. Bull. Chim. Ther. 6: 458-462
12. Domino, E. F., Wilson, A. E. (1973) Enhanced utilization of brain acetylcholine during morphine withdrawal in the rat. Nature 243: 285-286
13. Fann, M. L., Souccar, C., Lapa, A. J. (1990) Phethonium, a quaternary derivative of (-)-hyoscyamine, enhances the spontaneous release of acetylcholine at rat motor nerve terminals. Br. J. Pharmacol. 100: 441-446
14. Ferrari, V., Frigerio, G., Lodola, E. (1968) Esperienze di valutazione clinica iniziale di attivit. Analgesiche. Bull. Chim. Pharm. 107: 17-28
15. Hano, K., Kaneto, H., Kakunaga, T., Moribayashi, N. (1964) The administration of morphine and changes in acetylcholine metabolism in mouse brain. Biochem. Pharm. 13: 441-447
16. Harris, L. S., Dewey, W. L., Howes, J. F., Kennedy, J. S., Pars, H. (1969) Narcotic antagonist analgesics: interaction with cholinergic systems. J. Pharmacol. Exp. Ther. 169: 17-22
17. Hynes, M. D., Gianutsos, G., Lal, H. (1976) Effects of cholinergic agonists and antagonists on morphine-withdrawal syndrome. Psychopharmacology 49: 191-195
18. Jhamandas, K., Sutak, M., Bell, S. (1973) Modification of precipitated morphine-withdrawal syndrome by drugs affecting cholinergic mechanisms. Eur. J. Pharmacol. 24: 296-305
19. Kruszewska, A., Langwinski, R. (1983) The role of central 5-hydroxytryptamineergic neurotransmission in the morphine abstinence syndrome in rats. Drug Alcohol Depend. 12: 273-278
20. Large, W. A., Milton, A. S. (1970) The effect of acute and chronic morphine administration on brain acetylcholine levels in the rat. Br. J. Pharmacol. 38: 451-452
21. Martin, W. R., Jasinski, D. R. (1977) Assessment of the abuse potential of narcotic analgesics in animals. In: Martin, W. R. (ed.) Handbook of Experimental Pharmacology. Vol. 45/1, Chapter 2, Springer, Berlin, pp 159-196
22. Milani, J. M., Merlo, E., Salambrino, S., Viganò, R. (1986) A double-blind trial of phentonium bromide in the treatment of incontinent unstable bladder. Int. J. Clin. Pharm. Ther. 24: 421-422
23. Moroni, M., Frigerio, G. (1977) A controlled trial of phentonium bromide in the treatment of the irritable colon syndrome. Curr. Ther. Res. 21: 619-628
24. Pinsky, C., Frederickson, R. C. A., Vasquez, A. J. (1973) Morphine-withdrawal syndrome: response to cholinergic antagonists and partial cholinergic agonists. Nature 242: 59-60
25. Redmond, D. E., Krystal, J. H. (1984) Multiple mechanisms of withdrawal from opioid drugs. Ann. Rev. Neurosci. 7: 443-478
26. Rupreht, J., Dworacek, B. (1983-84) Physostigmine versus naloxone in heroin-overdose. Clin. Toxicol. 21: 387-397
27. Sen, A. P., Bhattacharya, S. K. (1991) Thermic response of selective muscarinic agonists and antagonists in rat. Ind. Exp. Biology 29: 131-135
28. Sharkawi, M. (1972) Morphine hyperthermia in the rat. Its attenuation by physostigmine. Br. J. Pharmacol. 44: 544-548
29. Turski, W. A., Czuczwar, S. J., Turski, L., Sieklucka-Dziuba, M., Kleinrok, Z. (1984) Studies on the mechanism of wet-dog shakes produced by carbachol in rats. Pharmacology 28: 112-120