Cu-catalyzed alkylation of Grignard reagents: A new efficient procedure

Tetrahedron

Volumn 56, Issue 18, 2000, Pages 2733-2737

  Cahiez, Gérard ^a   Chaboche, Christophe ^a   Jézéquel, Michelle ^a  

^a Allée du Réseau Jean Marie Buckmaster   (France)

Author keywords

Copper catalyzed alkylation; Cross coupling reaction; Grignard reagents; Solvent effects

Indexed keywords

AMIDE; COPPER; ESTER; MAGNESIUM CHLORIDE; MAGNESIUM DERIVATIVE; NITRILE;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; PRIORITY JOURNAL; SYNTHESIS;

EID: 0034725031     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(00)00128-9     Document Type: Article

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14. The main reaction was the 1,2-addition to the ketone. Two products were isolated; the tertiary alcohol I (yield: 31.5%) and the tetrahydropyran II (yield: 38.5%) resulting from the in situ cyclization of the bromoalcoholate.