Fracture risk in users of oral anticoagulants: A nationwide case-control study

International Journal of Cardiology

Volumn 118, Issue 3, 2007, Pages 338-344

  Rejnmark, Lars ^a   Vestergaard, Peter ^a   Mosekilde, Leif ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Case control study; Fracture; Oral anticoagulants; Phenprocoumon; Warfarin

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; PHENPROCOUMON; WARFARIN;

ADULT; ARTICLE; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONFOUNDING VARIABLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FOREARM FRACTURE; FRACTURE; HIP FRACTURE; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK; SPINE FRACTURE;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGE DISTRIBUTION; ANTICOAGULANTS; BONE DENSITY; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; CROSS-SECTIONAL STUDIES; DENMARK; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FRACTURES, BONE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; ODDS RATIO; PROBABILITY; RISK ASSESSMENT; SEX DISTRIBUTION;

EID: 34247621869     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2006.07.022     Document Type: Article

References (32)

1. Ansell J., Hirsh J., Poller L., Bussey H., Jacobson A., and Hylek E. The pharmacology and management of the vitamin K antagonists: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (2004) 204S-233S
2. Hara K., Akiyama Y., Tajima T., and Shiraki M. Menatetrenone inhibits bone resorption partly through inhibition of PGE2 synthesis in vitro. J Bone Miner Res 8 (1993) 535-542
3. Takeuchi Y., Suzawa M., Fukumoto S., and Fujita T. Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone 27 (2000) 769-776
4. Berkner K.L. The vitamin K-dependent carboxylase. J Nutr 130 (2000) 1877-1880
5. Kalkwarf H.J., Khoury J.C., Bean J., and Elliot J.G. Vitamin K, bone turnover, and bone mass in girls. Am J Clin Nutr 80 (2004) 1075-1080
6. Szulc P., Arlot M., Chapuy M.C., Duboeuf F., Meunier P.J., and Delmas P.D. Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res 9 (1994) 1591-1595
7. Booth S.L., Broe K.E., Peterson J.W., et al. Associations between vitamin K biochemical measures and bone mineral density in men and women. J Clin Endocrinol Metab 89 (2004) 4904-4909
8. Szulc P., Chapuy M.C., Meunier P.J., and Delmas P.D. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 18 (1996) 487-488
9. Vergnaud P., Garnero P., Meunier P.J., Breart G., Kamihagi K., and Delmas P.D. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS study. J Clin Endocrinol Metab 82 (1997) 719-724
10. Szulc P., Chapuy M.C., Meunier P.J., and Delmas P.D. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 91 (1993) 1769-1774
11. Hodges S.J., Akesson K., Vergnaud P., Obrant K., and Delmas P.D. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res 8 (1993) 1241-1245
12. Hart J.P., Shearer M.J., Klenerman L., et al. Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab 60 (1985) 1268-1269
13. Luukinen H., Kakonen S.M., Pettersson K., et al. Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J Bone Miner Res 15 (2000) 2473-2478
14. Shiraki M., Shiraki Y., Aoki C., and Miura M. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 15 (2000) 515-521
15. Braam L.A., Knapen M.H., Geusens P., et al. Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif Tissue Int 73 (2003) 21-26
16. Sato Y., Honda Y., Kaji M., et al. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 31 (2002) 114-118
17. Orimo H., Shiraki M., Tomita A., Morii H., Fujita T., and Ohata M. Effects of menatetrenone on the bone and calcium metabolism in osteoporosis: a double-blind placebo-controlled study. J Bone Miner Metab 16 (1998) 106-112
18. Shiomi S., Nishiguchi S., Kubo S., et al. Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. Am J Gastroenterol 97 (2002) 978-981
19. Caraballo P.J., Gabriel S.E., Castro M.R., Atkinson E.J., and Melton III L.J. Changes in bone density after exposure to oral anticoagulants: a meta-analysis. Osteoporos Int 9 (1999) 441-448
20. Caraballo P.J., Heit J.A., Atkinson E.J., et al. Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med 159 (1999) 1750-1756
21. Jamal S.A., Browner W.S., Bauer D.C., and Cummings S.R. Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 128 (1998) 829-832
22. Frank L. Epidemiology. When an entire country is a cohort. Science 287 (2000) 2398-2399
23. Andersen T.F., Madsen M., Jorgensen J., Mellemkjoer L., and Olsen J.H. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 46 (1999) 263-268
24. Vestergaard P., and Mosekilde L. Fracture risk in patients with celiac disease, Crohn's disease, and ulcerative colitis: a nationwide follow-up study of 16,416 patients in Denmark. Am J Epidemiol 156 (2002) 1-10
25. Wacholder S., McLaughlin J.K., Silverman D.T., and Mandel J.S. Selection of controls in case-control studies. I. Principles. Am J Epidemiol 135 (1992) 1019-1028
26. Nielsen G.L., Sorensen H.T., Zhou W., Steffensen F.H., and Olsen J. The pharmacoepidemiologic prescription database of North Jutland-a valid tool in pharmacoepidemiological research. Int J Risk Saf Med 10 (1997) 203-205
27. Capella D. Descriptive tools and analysis. In: Dukes M. (Ed). Drug utilization studies: methods and uses (1993), WHO Regional Publications, Copenhagen 55-58
28. Charlson M.E., Pompei P., Ales K.L., and MacKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40 (1987) 373-383
29. de Groot V., Beckerman H., Lankhorst G.J., and Bouter L.M. How to measure comorbidity. a critical review of available methods. J Clin Epidemiol 56 (2003) 221-229
30. Miettinen O.S. Theoretical epidemiology: principles of occurrence research in medicine (1985), Wiley & Sons, New York
31. Pilon D., Castilloux A.M., Dorais M., and LeLorier J. Oral anticoagulants and the risk of osteoporotic fractures among elderly. Pharmacoepidemiol Drug Saf 13 (2004) 289-294
32. Hoidrup S., Gronbaek M., Gottschau A., Lauritzen J.B., and Schroll M. Alcohol intake, beverage preference, and risk of hip fracture in men and women. Copenhagen Centre for Prospective Population Studies. Am J Epidemiol 149 (1999) 993-1001