Phenotypic and genotypic characterization of imipenem-resistant Pseudomonas aeruginosa isolated in Buenos Aires;Caracterización fenotípica y genotípica de la resistencia a imipenem en Pseudomonas aeruginosa aisladas en un hospital de Buenos Aires

Revista Argentina de Microbiologia

Volumn 40, Issue 4, 2008, Pages 238-245

  Cejas, D ^a   Almuzara, M ^b   Santella, G ^a   Tuduri, A ^b   Palombarani, S ^b   Figueroa, S ^b   Gutkind, G ^a   Radice, M ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Hospital Interzonal General de Agudos Eva Peronquot   (Argentina)

Author keywords

Carbapenem resistance; Carbapenemases; Metallo lactamases

Indexed keywords

IMIPENEM; METALLO BETA LACTAMASE; OUTER MEMBRANE PROTEIN; BACTERIAL PROTEIN; BETA LACTAMASE; CEFTAZIDIME;

ANTIBIOTIC RESISTANCE; ARGENTINA; ARTICLE; BACTERIUM ISOLATION; CONTROLLED STUDY; GENOTYPE; HEALTH CARE FACILITY; NONHUMAN; PHENOTYPE; PSEUDOMONAS AERUGINOSA; CLASSIFICATION; CROSS INFECTION; DNA SEQUENCE; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; MULTIDRUG RESISTANCE; PSEUDOMONAS INFECTION;

ARGENTINA; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CEFTAZIDIME; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENOTYPE; IMIPENEM; MICROBIAL SENSITIVITY TESTS; PHENOTYPE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SEQUENCE ANALYSIS, DNA;

EID: 61949442722     PISSN: 03257541     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Ambler R, Coulson A, Frère JM, Ghuysen JM, Joris B, Forsman M, et al. A standard numbering scheme for the class a β-lactamases. Biochem J 1991; 276: 269-72.
2. Arakawa Y, Shibata N, Shibayama K, Kurokawa H, Yagi T, Fujiwara H, et al. Convenient test for screening metallo-beta-lactamase-producing gram-negative bacteria by using thiol compounds. J Clin Microbiol 2000; 38: 40-3.
3. Bucca R, Mastroberti M, Centron D, Jorda Vargas L, Kovensky J. Emergencia de metalo-β-lactamasas en Pseudomonas spp. provenientes de infecciones en pacientes quemados. Congreso SADEBAC 2006, 2006, p. 16560.
4. Cavallo J, Hocquet D, Plesiat P, Fabre R, Roussel-Delvallez M. Susceptibility of Pseudomonas aeruginosa to antimicrobials: a 2004 French multicentre hospital study. J Antimicrob Chemother 2007; 59: 1021-4.
5. Cornaglia G, Akova M, Amicosante G, Canton R, Cauda R, Docquier JD, et al. Metallo-beta-lactamases as emerging resistance determinants in gram-negative pathogens: open issues. Int J Antimicrob Agents 2007; 29: 380-8.
6. Cuirolo A, Radice M, Gutkind G. Molecular characterization of Imp-13 producing Pseudomonas aeruginosa. 46th. ICAAC, 2006, Abstract C2-415, pag. 109, San Francisco, USA.
7. Docquier J, Luzzaro F, Amicosante G, Toniolo A, Rossolini GM. Multidrug-resistant Pseudomonas aeruginosa producing Per-1 extended-spectrum serine-beta-lactamase and Vim-2 metallo-beta-lactamase. Emerg Infect Dis 2001;7: 910-1.
8. Ellington M, Kistler J, Livermore D, Woodford N. Multiplex PCR for rapid detection of genes encoding acquired metallo-beta-lactamases. J Antimicrob Chemother 2007; 59: 321-2.
9. Gutierrez O, Juan C, Cercenado E, Navarro F, Bouza E, Coll P, et al. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals. Antimicrob Agents Chemother 2007; 51: 4329-35.
10. Hancock I, Poxton I. Bacterial Cell Surface Techniques. First ed. 1988. John Wiley and Sons.
11. Henrichfreise B, Wiegand I, Pfister W, Wiedemann B. Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation. Antimicrob Agents Chemother 2007; 51:4062-70.
12. Hogan D, Kolter R. Why are bacteria refractory to antimicrobials? Current Opinion in Microbiology 2002; 5:472-7.
13. Juan C, Macia M, Gutierrez O, Vidal C, Perez J, Oliver A. Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains. Antimicrob Agents Chemother 2005; 49:4733-8.
14. Köhler T, Michea-Hamzehpour M, Epp S, Pechere J-C. Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems. Antimicrob Agents Chemother 1999; 43: 424-7.
15. Kolayli F, Karadenizli A, Savli H, Ergen K, Hatirnaz O, Balikci E, et al. Effect of carbapenems on the transcriptional expression of the OprD, oprM and oprN genes in Pseudomonas aeruginosa. J Med Microbiol 2004; 53: 915-20.
16. Livermore DM. β-lactamases in laboratory and clinical resistance. Clin Microbiol Rev 1995; 8: 557-84.
17. Maniati M, Ikonomidis A, Mantzana P, Daponte A, Maniatis A, Pournaras S. A highly carbapenem-resistant Pseudomonas aeruginosa isolate with a novel blavim-4/blap1b integron overexpresses two efflux pumps and lacks oprD. J Antimicrob Chemother 2007; 60: 132-5.
18. Maseda H, Yoneyama H, Nakae T. Assignment of the substrate-selective subunits of the MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa. Antimicrob Agents Chemother 2000; 44: 658-64.
19. Masuda N, Sakagawa E, Ohya S. Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 1995; 39: 645-9.
20. Masuda N, Sakagawa E, Ohya S, Gotoh N, Tsujimoto H, Nishino T. Substrate specificities of Mex AB-OprM, MexCD-OprJ, and MexXY-OprM efflux pumps in Pseudomonas aeruginosa. Antimicrob Agents Chemother 2000; 44: 3322-7.
21. Mesaros N, Glupczynski Y, Avrain L, Caceres N, Tulkens P, Van Bambeke F. A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa. J Antimicrob Chemother 2007; 59: 378-86.
22. National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. Sixth edition. M7-A6. Performance standards for antimicrobial susceptibility testing. Fourteenth informational supplement. Wayne, Pa., 2004
23. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests; approved standard - Eighth edition - M2-A8, Performance standards for antimicrobial susceptibility testing. Fourteenth informational supplement. Wayne, Pa., 2004.
24. Ochs M, McCusker M, Bains M, Hancock R. Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids. Antimicrob Agents Chemother 1999; 43: 1085-90.
25. Page M I. The reactivity of beta-lactams, the mechanism of catalysis and the inhibition of beta-lactamases. Curr Pharm Des 1999; 5: 895-913.
26. Pagniez G, Radice M, Cuirolo A. Rodríguez O, Rodríguez H, Vay C, et al. Prevalencia de metalo-β-lactamasas en Pseudomonas aeruginosa resistentes a carbapenemes enun Hospital Universitario de Buenos Aires. Rev Argent Microbiol 2006; 38: 33-7.
27. Pagniez G, Radice M, Amoroso A, Famiglietti A, Gutkind G. Class I integron containing a new variant of Vim-2 metallo-beta-lactamase in Pseudomonas aeruginosa. 44 th. ICAAC, 2004, Abstract C1-293, p. 65, Washington, USA.
28. Pasteran F, Faccone D, Petroni A, Rapoport M, Galas M, Vazquez M, et al. Novel variant [bla(vim-11)] of the metallo-beta-lactamase bla(vim) family in a Ges-1 extended-spectrum-beta-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina. Antimicrob Agents Chemother 2005; 49: 474-5.
29. Quale J, Bratu S, Gupta J, Landman D. Interplay of efflux system, AmpC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother 2006; 50: 1633-41.
30. Queenan A, Bush K. Carbapenemases: the versatile beta- lactamases. Clin Microbiol Rev 2007; 20: 440-58.
31. Quinteros M, Radice M, Famiglietti A, Marín M, Nicola F, Casellas J M, et al. Análisis de la sensibilidad a los antimicrobianos en los aislamientos de pacientes internados. Años 2004-2005. http://www.aam.org.ar/novedades/2004-2005.pdf 2006.
32. Rossi A, Lopardo H, Woloj M, Picandet A, Mariño M, Galas M, et al. Non-typhoid Salmonella spp resistant to cefotaxime. J Antimicrob Chemother 1995; 36: 697-702.
33. Subcomisión de Antimicrobianos, SADEBAC, AAM. Caracterización fenotípica de la resistencia a los β-lactámicos en Pseudomonas aeruginosa y Acinetobacter spp. http://www.aam.org.ar/novedades/consenso%20BNNF%20 Anexo. pdf
34. Syrmis M, O'Carroll M, Sloots T, Coulter C, Wainwright C, Bell S, et al. Rapid genotyping of Pseudomonas aeruginosa isolates harboured by adult and paediatric patients with cystic fibrosis using repetitive-element- based PCR assays. J Med Microbiol 2004; 53: 1089-96.
35. Tam V, Chang K, LaRocco M, Schilling A, McCauley K, Poole K, et al. Prevalence, mechanisms, and risk factors of carbapenem resistance in bloodstream isolates of Pseudomonas aeruginosa. Diagn Microbiol Infect Dis 2007; 58: 309-14.
36. Walsh T, Toleman M, Poirel L, Nordmann P. Metallo-beta-lactamases: The quiet before the storm? Clin Microbiol Rev 2005; 18: 306-325.
37. Wang C, Mi Z H. Imipenem-resistant Pseudomonas aeruginosa producing Imp-1 metallo-beta-lactamases and lacking the outer-membrane protein oprD. J Med Microbiol 2006; 55: 353-4.
38. Yong D, Ritchie B, Pratt R, Toleman M, Walsh T. A novel sub-group metallo-β-lactamase (MBL), Aim-1 emerges in Pseudomonas aeruginosa (Psa) from Australia. 47 th ICAAC, 2007, abstract C1-593, p. 75, Chicago, USA.