메뉴 건너뛰기




Volumn 13, Issue 2, 2009, Pages 121-126

Total serum homocysteine levels do not identify cognitive dysfunction in multimorbid elderly patients

Author keywords

Cognitive dysfunction; Folate; Homocysteine; Multimorbid elderly

Indexed keywords

CYANOCOBALAMIN; HEMOGLOBIN; HOMOCYSTEINE;

EID: 61949434395     PISSN: 12797707     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12603-009-0018-9     Document Type: Article
Times cited : (4)

References (48)
  • 1
    • 0026720760 scopus 로고
    • Nutritional factors in physical and cognitive functions of elderly people
    • Am J Clin Nutr
    • Rosenberg IH, Miller JW. Nutritional factors in physical and cognitive functions of elderly people. Am J Clin Nutr. 1992;55(6) Suppl:1237S-243S. Review.
    • (1992) Review , vol.55 , Issue.6 SUPPL. 1237S-243S
    • Rosenberg, I.H.1    Miller, J.W.2
  • 2
    • 0031597388 scopus 로고    scopus 로고
    • Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease
    • Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 1998;55(11):1449-55.
    • (1998) Arch Neurol , vol.55 , Issue.11 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 3
    • 0026684554 scopus 로고
    • A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians
    • Stampfer MJ, Malinow MR, Willett WC et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992;19;268(7):877-81.
    • (1992) JAMA , vol.268 , Issue.7 , pp. 877-881
    • Stampfer, M.J.1    Malinow, M.R.2    Willett, W.C.3
  • 4
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet. 1995;346(8987):1395-8.
    • (1995) Lancet , vol.346 , Issue.8987 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 5
    • 0031988993 scopus 로고    scopus 로고
    • Determinants of plasma homocysteine
    • Blom HJ. Determinants of plasma homocysteine. Am J Clin Nutr. 1998;67(2):188-9.
    • (1998) Am J Clin Nutr , vol.67 , Issue.2 , pp. 188-189
    • Blom, H.J.1
  • 6
    • 0035116352 scopus 로고    scopus 로고
    • Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
    • Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr. 2001;73(3):613-21.
    • (2001) Am J Clin Nutr , vol.73 , Issue.3 , pp. 613-621
    • Jacques, P.F.1    Bostom, A.G.2    Wilson, P.W.3    Rich, S.4    Rosenberg, I.H.5    Selhub, J.6
  • 7
    • 37349107157 scopus 로고    scopus 로고
    • Homocysteine as a biomarker for cognitive dysfunction in the elderly
    • Schulz RJ. Homocysteine as a biomarker for cognitive dysfunction in the elderly. Curr Opin Nutr Metab Care. 2007;10:718-723.
    • (2007) Curr Opin Nutr Metab Care , vol.10 , pp. 718-723
    • Schulz, R.J.1
  • 8
    • 0028170372 scopus 로고
    • Serum vitamin B12 levels and incidence of dementia in a healthy elderly population: A report from the Bronx Longitudinal Aging Study
    • Crystal HA, Ortof E, Frishman WH, Gruber A, Hershman D, Aronson M. Serum vitamin B12 levels and incidence of dementia in a healthy elderly population: a report from the Bronx Longitudinal Aging Study. J Am Geriatr Soc. 1994;42(9):933-6.
    • (1994) J Am Geriatr Soc , vol.42 , Issue.9 , pp. 933-936
    • Crystal, H.A.1    Ortof, E.2    Frishman, W.H.3    Gruber, A.4    Hershman, D.5    Aronson, M.6
  • 9
    • 0029905218 scopus 로고    scopus 로고
    • The significance of subnormal serum vitamin B12 concentration in older people: A case control study
    • Metz J, Bell AH, Flicker L, Bottiglieri T et al. The significance of subnormal serum vitamin B12 concentration in older people: a case control study. J Am Geriatr Soc. 1996;44(11):1355-61.
    • (1996) J Am Geriatr Soc , vol.44 , Issue.11 , pp. 1355-1361
    • Metz, J.1    Bell, A.H.2    Flicker, L.3    Bottiglieri, T.4
  • 10
    • 0029865065 scopus 로고    scopus 로고
    • Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study
    • Riggs KM, Spiro A 3rd, Tucker K, Rush D. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr. 1996;63(3):306-14.
    • (1996) Am J Clin Nutr , vol.63 , Issue.3 , pp. 306-314
    • Riggs, K.M.1    Spiro 3rd, A.2    Tucker, K.3    Rush, D.4
  • 11
    • 0031028267 scopus 로고    scopus 로고
    • Nutritional status and cognitive functioning in a normally aging sample: A 6-y reassessment
    • Jan;
    • La Rue A, Koehler KM, Wayne SJ, Chiulli SJ, Haaland KY, Garry PJ. Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment. Am J Clin Nutr. 1997 Jan;65(1):20-9.
    • (1997) Am J Clin Nutr , vol.65 , Issue.1 , pp. 20-29
    • La Rue, A.1    Koehler, K.M.2    Wayne, S.J.3    Chiulli, S.J.4    Haaland, K.Y.5    Garry, P.J.6
  • 12
    • 0029956585 scopus 로고    scopus 로고
    • Effects of serum vitamin B12 and folate status on episodic memory performance in very old age: A population-based study
    • Wahlin A, Hill RD, Winblad B, Backman L. Effects of serum vitamin B12 and folate status on episodic memory performance in very old age: a population-based study. Psychol Aging. 1996;11(3):487-96.
    • (1996) Psychol Aging , vol.11 , Issue.3 , pp. 487-496
    • Wahlin, A.1    Hill, R.D.2    Winblad, B.3    Backman, L.4
  • 13
    • 0026575714 scopus 로고
    • Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status
    • Andersson A, Brattstrom L, Israelsson B, Isaksson A, Hamfelt A, Hultberg B. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status. Eur J Clin Invest. 1992;22(2):79-87.
    • (1992) Eur J Clin Invest , vol.22 , Issue.2 , pp. 79-87
    • Andersson, A.1    Brattstrom, L.2    Israelsson, B.3    Isaksson, A.4    Hamfelt, A.5    Hultberg, B.6
  • 14
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270(22):2693-8.
    • (1993) JAMA , vol.270 , Issue.22 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.3    Rush, D.4    Rosenberg, I.H.5
  • 15
    • 0035143383 scopus 로고    scopus 로고
    • Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore
    • Saw SM, Yuan JM, Ong CN, Arakawa K, Lee HP, Coetzee GA, Yu MC. Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. Am J Clin Nutr. 2001;73(2):232-9.
    • (2001) Am J Clin Nutr , vol.73 , Issue.2 , pp. 232-239
    • Saw, S.M.1    Yuan, J.M.2    Ong, C.N.3    Arakawa, K.4    Lee, H.P.5    Coetzee, G.A.6    Yu, M.C.7
  • 16
    • 5644250686 scopus 로고    scopus 로고
    • Homocysteine and cognitive function in elderly people
    • Review
    • Garcia A, Zanibbi K. Homocysteine and cognitive function in elderly people. CMAJ. 2004;171(8):897-904. Review.
    • (2004) CMAJ , vol.171 , Issue.8 , pp. 897-904
    • Garcia, A.1    Zanibbi, K.2
  • 17
    • 0034116129 scopus 로고    scopus 로고
    • Plasma total homocysteine and cognitive performance in a volunteer elderly population
    • Budge M, Johnston C, Hogervorst E et al. Plasma total homocysteine and cognitive performance in a volunteer elderly population. Ann N Y Acad Sci. 2000;903:407-10.
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 407-410
    • Budge, M.1    Johnston, C.2    Hogervorst, E.3
  • 19
    • 0038219536 scopus 로고    scopus 로고
    • Homocysteine: A marker for cognitive performance? A longitudinal follow-up study
    • Teunissen CE, Blom AH, Van Boxtel MP et al. Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. J Nutr Health Aging. 2003;7(3):153-9.
    • (2003) J Nutr Health Aging , vol.7 , Issue.3 , pp. 153-159
    • Teunissen, C.E.1    Blom, A.H.2    Van Boxtel, M.P.3
  • 20
    • 0033178883 scopus 로고    scopus 로고
    • Total homocysteine and cognitive decline in a community-based sample of elderly subjects: The Rotterdam Study
    • Kalmijn S, Launer LJ, Lindemans J, Bots ML, Hofman A, Breteler MM. Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study. Am J Epidemiol. 1999;150(3):283-9.
    • (1999) Am J Epidemiol , vol.150 , Issue.3 , pp. 283-289
    • Kalmijn, S.1    Launer, L.J.2    Lindemans, J.3    Bots, M.L.4    Hofman, A.5    Breteler, M.M.6
  • 21
    • 0034518250 scopus 로고    scopus 로고
    • Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects
    • Ravaglia G, Forti P, Maioli F et al. Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects. J Nutr Health Aging. 2000;4(4):218-22.
    • (2000) J Nutr Health Aging , vol.4 , Issue.4 , pp. 218-222
    • Ravaglia, G.1    Forti, P.2    Maioli, F.3
  • 22
    • 61949386791 scopus 로고    scopus 로고
    • Erzigkeit H. SKT: The SKT: a short cognitive performance test as an instrument for the assessment of clinical efficacy of cognition enhancers. In: Bergener M, Reisberg B (eds.). Diagnosis and treatment of senile dementia. New York: Springer-Verlag; 1989:164-174
    • Erzigkeit H. SKT: The SKT: a short cognitive performance test as an instrument for the assessment of clinical efficacy of cognition enhancers. In: Bergener M, Reisberg B (eds.). Diagnosis and treatment of senile dementia. New York: Springer-Verlag; 1989:164-174
  • 24
    • 0026498857 scopus 로고
    • Equations for predicting stature in white and black elderly individuals
    • Chumlea WC, Guo S. Equations for predicting stature in white and black elderly individuals. J Gerontol. 1992;47:M197-M203
    • (1992) J Gerontol , vol.47
    • Chumlea, W.C.1    Guo, S.2
  • 25
    • 2842601494 scopus 로고
    • Mini Nutritional Assessment: A practical assessment tool for grading the nutritional state of elderly patients
    • Guigoz Y, Vellas B, Garry PJ. Mini Nutritional Assessment: A practical assessment tool for grading the nutritional state of elderly patients. Facts and Research in Gerontology. 1994;Suppl. 2: 15-59.
    • (1994) Facts and Research in Gerontology , vol.2 , Issue.SUPPL. , pp. 15-59
    • Guigoz, Y.1    Vellas, B.2    Garry, P.J.3
  • 26
    • 27044432604 scopus 로고
    • A biometric study of human basal metabolism
    • Harris JA, Benedict FG. A biometric study of human basal metabolism. Proc Natl Acad Sci. USA 1918;4(12):370-3.
    • (1918) Proc Natl Acad Sci. USA , vol.4 , Issue.12 , pp. 370-373
    • Harris, J.A.1    Benedict, F.G.2
  • 27
    • 70450195021 scopus 로고
    • Functional evaluation: The Bathel Index
    • Mahoney FI, Barthel DW. Functional evaluation: The Bathel Index. Md State Med J. 1965; 14:61-5.
    • (1965) Md State Med J , vol.14 , pp. 61-65
    • Mahoney, F.I.1    Barthel, D.W.2
  • 28
    • 0033004216 scopus 로고    scopus 로고
    • Serum total homocysteine concentrations in adolescent and adult Americans: Results from the third National Health and Nutrition Examination Survey
    • Jacques PF, Rosenberg IH, Rogers G et al. Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 1999;69(3):482-9.
    • (1999) Am J Clin Nutr , vol.69 , Issue.3 , pp. 482-489
    • Jacques, P.F.1    Rosenberg, I.H.2    Rogers, G.3
  • 29
    • 2942716893 scopus 로고    scopus 로고
    • Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors
    • Strassburg A, Krems C, Luhrmann PM et al. Effect of age on plasma homocysteine concentrations in young and elderly subjects considering serum vitamin concentrations and different lifestyle factors. Int J Vitam Nutr Res. 2004;74(2):129-36.
    • (2004) Int J Vitam Nutr Res , vol.74 , Issue.2 , pp. 129-136
    • Strassburg, A.1    Krems, C.2    Luhrmann, P.M.3
  • 30
    • 4444355689 scopus 로고    scopus 로고
    • Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population
    • Huerta JM, Gonzalez S, Vigil E et al. Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population. Clin Biochem. 2004;37(10):904-10.
    • (2004) Clin Biochem , vol.37 , Issue.10 , pp. 904-910
    • Huerta, J.M.1    Gonzalez, S.2    Vigil, E.3
  • 31
    • 0142088607 scopus 로고    scopus 로고
    • B vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women
    • Wolters M, Hermann S, Hahn A. B vitamin status and concentrations of homocysteine and methylmalonic acid in elderly German women. Am J Clin Nutr. 2003;78(4):765-72.
    • (2003) Am J Clin Nutr , vol.78 , Issue.4 , pp. 765-772
    • Wolters, M.1    Hermann, S.2    Hahn, A.3
  • 32
    • 17444434174 scopus 로고
    • Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. 1988
    • Lindenbaum J, Healton EB, Savage DG et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. 1988. Nutrition. 1995;11(2):181
    • (1995) Nutrition , vol.11 , Issue.2 , pp. 181
    • Lindenbaum, J.1    Healton, E.B.2    Savage, D.G.3
  • 33
    • 0035050096 scopus 로고    scopus 로고
    • National Health and Nutrition Examination Survey. Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey
    • Morris MS, Jacques PF, Rosenberg IH, Selhub J; National Health and Nutrition Examination Survey. Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 2001;73(5):927-33.
    • (2001) Am J Clin Nutr , vol.73 , Issue.5 , pp. 927-933
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 34
    • 0037075257 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    • Seshadri S, Beiser A, Selhub J et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346(7):476-83.
    • (2002) N Engl J Med , vol.346 , Issue.7 , pp. 476-483
    • Seshadri, S.1    Beiser, A.2    Selhub, J.3
  • 35
    • 0034604524 scopus 로고    scopus 로고
    • Changes in the intracellular homocysteine and glutathione content associated with aging
    • Hernanz A, Fernandez-Vivancos E, Montiel C, Vazquez JJ, Arnalich F. Changes in the intracellular homocysteine and glutathione content associated with aging. Life Sci. 2000;67(11):1317-24.
    • (2000) Life Sci , vol.67 , Issue.11 , pp. 1317-1324
    • Hernanz, A.1    Fernandez-Vivancos, E.2    Montiel, C.3    Vazquez, J.J.4    Arnalich, F.5
  • 36
    • 0021284472 scopus 로고
    • Folate and vitamin B12 status in a healthy elderly population
    • Garry PJ, Goodwin JS, Hunt WC. Folate and vitamin B12 status in a healthy elderly population. J Am Geriatr Soc. 1984;32(10):719-26.
    • (1984) J Am Geriatr Soc , vol.32 , Issue.10 , pp. 719-726
    • Garry, P.J.1    Goodwin, J.S.2    Hunt, W.C.3
  • 38
    • 0027423427 scopus 로고
    • Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency
    • Review
    • Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J. 1993;7(14):1344-53. Review.
    • (1993) FASEB J , vol.7 , Issue.14 , pp. 1344-1353
    • Allen, R.H.1    Stabler, S.P.2    Savage, D.G.3    Lindenbaum, J.4
  • 39
    • 0035652251 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects
    • Ventura P, Panini R, Verlato C, Scarpetta G, Salvioli G. Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects. Metabolism. 2001;50:1466-71.
    • (2001) Metabolism , vol.50 , pp. 1466-1471
    • Ventura, P.1    Panini, R.2    Verlato, C.3    Scarpetta, G.4    Salvioli, G.5
  • 40
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10(1):111-3.
    • (1995) Nat Genet , vol.10 , Issue.1 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 41
    • 0242577783 scopus 로고    scopus 로고
    • Framingham Offspring Study Cohort. Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homoeysteine concentrations in the Framingham Offspring Study Cohort
    • Russo GT, Friso S, Jacques PF et al; Framingham Offspring Study Cohort. Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homoeysteine concentrations in the Framingham Offspring Study Cohort. J Nutr. 2003;133(11):3416-21.
    • (2003) J Nutr , vol.133 , Issue.11 , pp. 3416-3421
    • Russo, G.T.1    Friso, S.2    Jacques, P.F.3
  • 42
    • 0030763118 scopus 로고    scopus 로고
    • Diagnosis of cobalamin deficiency: The old and the new
    • Chanarin I, Metz J. Diagnosis of cobalamin deficiency: the old and the new. Br J Haematol. 1997;97(4):695-700.
    • (1997) Br J Haematol , vol.97 , Issue.4 , pp. 695-700
    • Chanarin, I.1    Metz, J.2
  • 43
    • 0023870112 scopus 로고
    • Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry
    • Stabler SP, Marcell PD, Podell ER, Allen RH, Savage DG, Lindenbaum J. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest. 1988;81(2):466-74.
    • (1988) J Clin Invest , vol.81 , Issue.2 , pp. 466-474
    • Stabler, S.P.1    Marcell, P.D.2    Podell, E.R.3    Allen, R.H.4    Savage, D.G.5    Lindenbaum, J.6
  • 44
    • 48249094979 scopus 로고    scopus 로고
    • Changes in folate, vitamin B12, and homocysteine associated with incident dementia. J Neurol Neurosurg Psychiatry
    • Feb
    • Kim JM, Stewart R, Kim SW, Yang SJ, Shin HY, Shin, IS, Yoon JS. Changes in folate, vitamin B12, and homocysteine associated with incident dementia. J Neurol Neurosurg Psychiatry. 2008; Feb 5 (in print).
    • (2008) 5 (in print)
    • Kim, J.M.1    Stewart, R.2    Kim, S.W.3    Yang, S.J.4    Shin, H.Y.5    Shin, I.S.6    Yoon, J.S.7
  • 45
    • 33846211794 scopus 로고    scopus 로고
    • Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: A randomised, double blind, controlled trial
    • Jan 20;
    • Durga J, van Boxtel MP, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet. 2007 Jan 20;369(9557):208-16.
    • (2007) Lancet , vol.369 , Issue.9557 , pp. 208-216
    • Durga, J.1    van Boxtel, M.P.2    Schouten, E.G.3    Kok, F.J.4    Jolles, J.5    Katan, M.B.6    Verhoef, P.7
  • 46
    • 33745315000 scopus 로고    scopus 로고
    • Homocysteine measurements in geriatric patients
    • Raeder S, Landaas S, Laake K, et al. Homocysteine measurements in geriatric patients. Scand J Clin Lab Invest. 2006; 66:309-315.
    • (2006) Scand J Clin Lab Invest , vol.66 , pp. 309-315
    • Raeder, S.1    Landaas, S.2    Laake, K.3
  • 47
    • 0031028267 scopus 로고    scopus 로고
    • Nutritional status and cognitive functioning in a normally aging sample: A 6-y reassessment
    • La Rue A, Koehler KM, Wayne SJ, et al. Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment. Am J Clin Nutr. 1997; 65:20-29.
    • (1997) Am J Clin Nutr , vol.65 , pp. 20-29
    • La Rue, A.1    Koehler, K.M.2    Wayne, S.J.3
  • 48
    • 0033551352 scopus 로고    scopus 로고
    • The effect of folic acid fortification on plasma folate and total homocysteine concentrations
    • May 13;
    • Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 1999 May 13;340(19):1449-54
    • (1999) N Engl J Med , vol.340 , Issue.19 , pp. 1449-1454
    • Jacques, P.F.1    Selhub, J.2    Bostom, A.G.3    Wilson, P.W.4    Rosenberg, I.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.