Changes in folate, vitamin B12 and homocysteine associated with incident dementia

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 79, Issue 8, 2008, Pages 864-868

  Kim, J M ^a   Stewart, R ^b   Kim, S W ^a   Shin, I S ^a   Yang, S J ^a   Shin, H Y ^c   Yoon, Jin Sang ^a,c  

^a Chonnam National University Medical School   (South Korea)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c Chonnam National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

AGE DISTRIBUTION; AGED; ALCOHOL CONSUMPTION; ALZHEIMER DISEASE; ARTICLE; BLOOD LEVEL; CARDIOVASCULAR RISK; CLINICAL ASSESSMENT; CYANOCOBALAMIN BLOOD LEVEL; DEMENTIA; DEPRESSION; DIAGNOSTIC TEST; DISABILITY; EDUCATIONAL STATUS; FEMALE; FOLIC ACID BLOOD LEVEL; FOLLOW UP; GERIATRIC PATIENT; HOMOCYSTEINE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SEX; VITAMIN INTAKE; WEIGHT CHANGE; BLOOD; CYANOCOBALAMIN DEFICIENCY; DAILY LIFE ACTIVITY; MENTAL HEALTH; MULTIINFARCT DEMENTIA; NEUROPSYCHOLOGICAL TEST; PREDICTION AND FORECASTING; PROSPECTIVE STUDY; REFERENCE VALUE;

ACTIVITIES OF DAILY LIVING; AGED; ALZHEIMER DISEASE; DEMENTIA; DEMENTIA, VASCULAR; FEMALE; FOLIC ACID; FOLLOW-UP STUDIES; HOMOCYSTEINE; HUMANS; MALE; MENTAL STATUS SCHEDULE; NEUROPSYCHOLOGICAL TESTS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REFERENCE VALUES; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 48249094979     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2007.131482     Document Type: Article

References (28)

1. Catoni GL. S-adnosylmethionine: a new intermediate formed enzymatically form L-methionine and adenosinetriphosphate. J Biol Chem 1953;204:403-6.
2. Van Praag HM. Depression. Lancet 1982;2:1259-83.
3. Bottiglieri T, Hyland K, Reynolds EH. The clinical potential role of ademetionine (S-adenosylmethionine) in neurological disorders. Drugs 1994;48:137-52.
4. 12, and serum total homocysteine concentrations in confirmed Alzheimer disease. Arch Neurol 1998;55:1449-55.
5. Stewart R, Asonganyi B, Sherwood R. Plasma homocysteine and cognitive impairment in an older British African-Caribbean population. J Am Geriatr Soc 2002;50:1227-32.
6. Ramos MI, Allen LH, Mungas DM, et al. Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging. Am J Clin Nutr 2005;82:1346-52.
7. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-83.
8. Luchsinger JA, Tang MX, Shea S, et al. Plasma homocysteine levels and risk of Alzheimer's disease. Neurology 2004;62:1972-6.
9. Haan MN, Miller JW, Aiello AE, et al. Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging. Am J Clin Nutr 2007;85:511-17.
10. Skoog I, Lernfeit B, Landahl S, et al. 15-year longitudinal study of blood pressure and dementia. Lancet 1996;347:1141-5.
11. Stewart R, Masaki K, Xue QL, et al. A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol 2005;62:55-60.
12. Kim JM, Stewart R, Shin IS, et al. Limb length and dementia in an older Korean population. J Neurol Neurosurg Psychiatry 2003;74:427-32.
13. Kim JM, Stewart R, Shin IS, et al. Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population. Neurobiol Aging 2004;25:295-301.
14. Kim JM, Stewart R, Kim SW, et al. Vascular risk factors and incident late-life depression in a Korean population. Br J Psychiatry 2006;189:26-30.
15. Park JH, Kwon YC. Modification of the Mini-Mental State Examination for use in the elderly in a non-western society: Part I. Development of Korean version of Mini-Mental State Examination. Int J Geriatr Psychiatry 1990;5:381-7.
16. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969;9:179-86.
17. Hughes CP, Berg L, Danziger WL, et al. A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140:566-72.
18. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder, 4th edn. Washington DC: American Psychiatric Press, 1994.
19. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
20. Roman GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993;43:250-60.
21. Kim JM, Stewart R, Glozier N, et al. Physical health, depression and cognitive function as correlates of disability in an older Korean population. Int J Geriatr Psychiatry 2005;20:160-7.
22. Copeland JR, Dewey ME, Griffiths-Jones HM. A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychol Med 1986;16:89-99.
23. Kim JM, Stewart R, Prince M, et al. Diagnosing dementia in a developing nation: an evaluation of the GMS-AGECAT algorithm in an older Korean population. Int J Geriatr Psychiatry 2003;18:331-6.
24. 12, folate, and homocysteine in depression: The Rotterdam Study. Am J Psychiatry 2002;159:2099-101.
25. Ravaglia G, Forti P, Maioli F, et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 2005;82:626-43.
26. Refsum H, Smith AD. Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry 2003;74:959-61.
27. Nurk E, Refsum H, Tell GS, et al. Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. Ann Neurol 2005;58:847-57.
28. Durga J, van Boxtel MP, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208-16.