Caloric intake and liver dysfunction in critically ill patients

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 12, Issue 2, 2009, Pages 175-179

  Grau, Teodoro ^a   Bonet, Alfonso ^b  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

Critically ill; Energy requirements; Insulin resistance; Liver dysfunction; Overfeeding

Indexed keywords

GLUCOSE;

ARTIFICIAL FEEDING; CALORIC INTAKE; CRITICALLY ILL PATIENT; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; LIVER DYSFUNCTION; LIVER METABOLISM; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; REVIEW; SEPSIS; SEPTIC SHOCK; STEATOSIS;

CRITICAL ILLNESS; ENERGY INTAKE; FATTY LIVER; GLUCOSE; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER; LIVER DISEASES; NUTRITIONAL SUPPORT; SEPSIS;

EID: 61949349334     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3283252f9e     Document Type: Review

References (34)

1. Chrousos GP. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995; 332:1351-1362.
2. A.S.P.E.N. Board of Directors and The Clinical Guidelines Task Force. Critical Care. JPEN J Parenter Enteral Nutr 2002; 26 (Suppl):90-92.
3. Kreymann KG, Berger MM, Deutz NE, et al. ESPEN guidelines on enteral nutrition: intensive Care. Clin Nutr 2006; 25:210-223.
4. Zauner C, Schuster BI, Schneeweiss B. Similar metabolic responses to standardized total parenteral nutrition of septic and nonseptic critically ill patients. Am J Clin Nutr 2001; 74:265-270.
5. Reid CL. Poor agreement between continuous measurements of energy expenditure and routinely used prediction equations in intensive care unit patients. Clin Nutr 2006; 27:649-657.
6. Grau T, Bonet A, Rubio M, et al., Working Group on Nutrition and Metabolism of the Spanish Society of Critical Care. Liver dysfunction associated with artificial nutrition in critically ill patients. Crit Care 2007; 11:R10. This longitudinal study correlates artificial nutrition associated liver dysfunction in critically ill patients with high amounts of caloric intake, whatever the route of feeding, with sepsis. Liver test alterations are frequently found in those older published papers.
7. Shepard PR, Kahn BB. Glucose transporters and insulin action. Implications for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341:248-325.
8. Roden M, Bernroider E. Hepatic glucose metabolism in humans: its role in health and disease. Best Pract Res Clin Endocrinol Metab 2003; 17:365-383.
9. Lam TK. Brain glucose metabolism controls hepatic glucose and lipid production. Cellscience 2007; 3:63-69.
10. Tappy L, Minehira K. New data and new concepts on the role of the liver in glucose homeostasis. Curr Opin Clin Nutr Metab Care 2001; 4:273-277.
11. Mizok BA. Alterations in fuel metabolism in critical illness: hyperglycaemia. Best Pract Res Clin Endocrinol Metab 2001; 15:533-551.
12. Mizok BA. Alterations in carbohydrate metabolism during stress: a review of the literature. Am J Med 1995; 98:75-84.
13. Haddad JJ, Saade'b NB, Safieh-Garabedian B. Cytokines and neuroimmune-endocrine interactions: a role for the hypothalamic-pituitary- adrenal revolving axis. J Neuroimmunol 2002; 133:1-19.
14. Hill AG. Initiators and propagators of the metabolic response to injury. World J Surg 2000; 24:624-629.
15. Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 2006; 68:123-158.
16. Schwarz J-M, Neese RA, Turner S, et al. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J Clin Invest 1995; 96:2735-2743.
17. Hellerstein MK. De novo lipogenesis in humans: metabolic and regulatory aspects. Eur J Clin Nutr 1999; 53:353-865.
18. Van den Berghe G, Wouters PJ, Bouillon R, et al. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003; 31:359-366.
19. Rnney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. J Am Med Assoc 2003; 290:2041-2047.
20. Van der Voot PHJ, Feenstra RA, Bakkert AJ, et al. Intravenous glucose intake independently related to intensive care unit and hospital mortality: an argument for glucose toxicity in critically ill patients. Clin Endocrinol 2006; 64:141-145.
21. Mechanick JI. Metabolism mechanisms of stress hyperglycemia. J Parenter Enteral Nutr 2006; 30:157-163.
22. Vanhorebeek I, De Vos R, Mesotten D, et al. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 2005; 365:53-59.
23. Cree MG, Zwetsloot JJ, Hemdon DN, et al. Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate. Ann Surg 2007; 245:214-221. This paper shows the beneficial effects of a drug used to improve insulin sensitivity in type 2 diabetes mellitus and critically ill burned children. This could confirm the hypothesis that insulin resistance in critically ill patients share the same underlying mechanisms of insulin resistance seen in type 2 diabetes mellitus.
24. Holecek M. Nutritional modulation of liver regeneration by carbohydrates, lipids and aminoacids: a review. Nutrition 1999; 15:784-788.
25. Postic C, Girard J. Contribution of the novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008; 118:829-838. A review of the effects of fatty acids on insulin resistance and the mechanism involved.
26. Cree MG, Wolfe RR. Postbum trauma insulin resistance and fat metabolism. Am J Physiol Endocrinol Metab 2008; 294:E1-E9. A review of insulin resistance and fat metabolism in trauma and burnt patients. The authors point out the common mechanisms of insulin resistance and fat metabolism derangements seen in these patients and patients with type 2 diabetes syndrome and metabolic syndrome.
27. Lam TKT, Carpentier A, Lewis GF, et al. Mechanisms of the free fatty acid-induced increase in hepatic glucose production. Am J Physiol Endocrinol Metab 2003; 284:863-873.
28. Rusavy Z, Macdonald IA, Sramek V, et al. Glycemia influences on glucose metabolism in sepsis durinig hyperinsulinemic clamp. J Parenter Enetral Nutr 2005; 29:171-175.
29. Saberi F, Heyland D, Lam M, et al. Prevelence, incidence and clinical resolution of insulin resistance in critically ill patients: an observational study. J Parenter Enteral Nutr 2008; 32:227-235. The authors perform a systematic evaluation of insulin resistance in critically ill patients over time using the HOMA test. Nevertheless, these studies have a major caveat: the HOMA test has not been validated against the gold standard test, hyperinsulinemic euglycemic clamp, in critically ill patients.
30. Leclercq IA, Da Silva Morais A, Schroyen B, et al. Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol 2007; 47:142-156.
31. Kramer L, Jordan B, Druml W, et al., for the Austrian Epidemiologic Study on Intensive Care, ASDI Study Group. Incidence and prognosis of early hepatic dysfunction in critically ill patients: a prospective multicenter study. Crit Care Med 2007 2007; 35:1099-1104. This study demonstrates that liver dysfunction assessed by changes in plasmatic bilirrubin appears early during the critically illness, and more importantly it correlates with the prognosis. Using these criteria, liver dysfunction in critically ill patients is more frequent than expected in previous studies.
32. Szabo G, Romics L, Frendl G. Liver in sepsis and systemic inflammatory response syndrome. Clin Liver Dis 2002; 6:1045-1066.
33. Marik PE, Raghavan M. Stress-hyperglycemia, insulin and immunomodulation in sepsis. Intensive Care Med 2004; 30:748-756.
34. Buchman A. Total Parenteral Nutrition-associated liver disease. J Parenter Enteral Nutr 2002; 26:S43-S48.