Glycemia influences on glucose metabolism in sepsis during hyperinsulinemic clamp

Journal of Parenteral and Enteral Nutrition

Volumn 29, Issue 3, 2005, Pages 171-175

  Rusavy, Zdenek ^a   Macdonald, Ian A ^b   Sramek, Vladimir ^c   Lacigova, Silvie ^a   Tesinsky, Pavel ^d   Novak, Ivan ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Department of Physiology and Pharmacology ^*  (United Kingdom)

^c UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYTOKINE; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; ISOPHANE INSULIN; NITROGEN; TUMOR NECROSIS FACTOR ALPHA;

ANALYSIS OF VARIANCE; ARTICLE; ARTIFICIAL VENTILATION; CALORIC INTAKE; CALORIMETRY; CLINICAL ARTICLE; ENERGY EXPENDITURE; ENTERIC FEEDING; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIC CLAMP; HYPERINSULINEMIA; INDIRECT CALORIMETRY; INSULIN INFUSION; PRIORITY JOURNAL; SEPSIS; STATISTICAL ANALYSIS; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; ENERGY METABOLISM; HOSPITALIZATION; INFUSION; METABOLISM; PHYSIOLOGY; URINE;

ANALYSIS OF VARIANCE; BLOOD GLUCOSE; CALORIMETRY, INDIRECT; CYTOKINES; ENERGY METABOLISM; GLUCOSE CLAMP TECHNIQUE; HUMANS; INFUSIONS, PARENTERAL; INSULIN; NITROGEN; SEPSIS; SEVERITY OF ILLNESS INDEX;

EID: 24744460357     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607105029003171     Document Type: Article

References (28)

1. Brandi LS, Santoro D, Natali A, et al. Insulin resistance of stress: sites and mechanisms. Clin Sci. 1993;85:525-535.
2. Gore DC, Wolf SE, Herndon DN, Wolfe RR. Relative influence of glucose and insulin on peripheral amino acid metabolism in severely burned patients. JPEN J Parenter Enteral Nutr. 2002;26:271-277.
3. Ling PR, Bistrian BR, Mendez B, Istfan NW. Effects of systemic infusions of endotoxin, tumor necrosis factor and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism. 1994;43:279-284.
4. Tappy L, Cayeux M, Schneiter P, et al. Effects of lactate on glucose metabolism in healthy subjects and in severely injured hyperglycemic patients. Am J Physiol. 1995;431:E630-E635.
5. Berg S, Sappington PL, Guzik LJ, Delude RL, Fink MP. Proinflammatory cytokines increase the rate of glycolysis and adenosine-5′-triphosphate turnover in cultured rat enterocytes. Crit Care Med. 2003;31:1203-1212.
6. Iscra F, Gullo A, Biolo G. Bench-to-bedside review: lactate and the lung. Crit Care Med 2002;6:327-329.
7. Mandarino LJ, Consoli A, Jain A, Kelley DE. Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle. Am J Physiol. 1993;265:E878-E905.
8. Henry RR, Gumbiner B, Flynn T, Thorburn AW. Metabolic effects of hyperglycemia and hyperinsulinemia on fate of intracellular glucose in NIDDM. Diabetes. 1990;39:149-156.
9. Pilz G, Appel R, Gurniak T, Bujdoso O, Werdan K. APACHE II und Elebute Score-Berechnung und Sepsisbeurteilung auf der Intensivstation anhand eines BASIC Computerprogramms. Intensivmed. 1992;29:81-89.
10. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistence. Am J Physiol. 1979;237:E214-E223.
11. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated cost of care. Crit Care Med 2001;29:1303-1310.
12. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345:1359-1367.
13. Malmberg K, Norhammar A, Wedel H, Ryden L. Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the DIGAMI study. Circulation. 1999;99:2626-2632.
14. Das UN. Is insulin an anti-inflammatory molecule? Nutrition 2001;17:409-413.
15. Gore DC, Wolf SE, Herndon DN, Wolfe RR. Relative influence of glucose and insulin on peripheral amino acid metabolism in severely burned patients. JPEN J Parenter Enteral Nutr 2002;26:271-277.
16. Rovlias A, Kotsou S. The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 2000;46:335-342.
17. Preiser JCH, Devos P, van den Berghe G. Tight control of glycemia in critically ill patients. Curr Opin Clin Nutr Metab Care. 2002;5:533-537.
18. Tappy L, Chioléro R, Berger M. Autoregulation of glucose production in health and disease. Curr Opin Clin Nutr Metab Care. 1999;2:161-164.
19. Wolfe RR, Martini WZ. Changes in intermediary metabolism in severe surgical illness. World J Surg. 2000;24:639-647.
20. Saeed M, Carlson GL, Little RA, Irving MH: Selective impairment of glucose storage in human sepsis. Brit J Surg. 1999;86:813-821.
21. Shangraw RE, Jahoor F, Miyoshi H, Neff WA, Stuart CA. Differentiation between septic and postburn insulin resistance. Metabolism. 1989;38:983-989.
22. Campbell IT. Limitations in nutrient intake. The effect of stressors: trauma sepsis and multiple organ failure. Eur J Clin Nutr. 1999;53:143-147.
23. Arnold J, Campbell IT, Hipkin LJ, Keegan M. Manipulation of substrate utilization with somatostatin in patients with secondary multiple organ dysfunction syndrome. Crit Care Med 1995;23:71-77.
24. Valarini R, Sousa MF, Kalil R, Abumrad NN, Riella MC. Anabolic effects of insulin and amino acids in promoting nitrogen accretion in postoperative patients. JPEN J Parenter Enteral Nutr 1994;18:214-218.
25. Jeevanandam M, Shamos RF, Petersen SR. Substrate efficacy in early nutrition support of critically ill multiple trauma victims. JPEN J Parenter Enteral Nutr 1992;16:511-520.
26. Zaloga GP, Roberts P. Permissive underfeeding. New Horizons 1994;2:257-263.
27. Katz JA, Lowry SF. Substrate use in hypermetabolism. In: Fein AM, ed. Sepsis and Multiorgan Failure. Baltimore, MD: Williams and Wilkins, 1997.
28. Yu WK, Li WQ, Li A, Li JS. Influence of acute hyperglycemia in human sepsis on inflammatory cytokine and contra-regulatory hormone concentrations. World J Gastroenterol 2003;9:1824-1827.