Effects of lead on cholinergic SN56 neuroblastoma cells

Acta Neurobiologiae Experimentalis

Volumn 68, Issue 4, 2008, Pages 453-462

  Jankowska Kulawy, Agnieszka ^a   Gul Hinc, Sylwia ^a   Bielarczyk, Hanna ^a   Suszkiw, Janusz B ^a   Pawełlczyk, Tadeusz ^b   Dyś, Aleksandra ^a   Szutowicz, Andrzej ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Acetyl CoA; Amyloid ; Choline acetyltransferase; Lead neurotoxicity

Indexed keywords

ACETYL COENZYME A; AMYLOID BETA PROTEIN; LEAD; NERVE PROTEIN; TRYPAN BLUE;

ARTICLE; BRAIN TUMOR; CELL COUNT; CELL SURVIVAL; CHOLINERGIC SYSTEM; HUMAN; LEAD POISONING; METABOLISM; NEUROBLASTOMA; PATHOLOGY; TUMOR CELL LINE;

ACETYL COENZYME A; AMYLOID BETA-PROTEIN; BRAIN NEOPLASMS; CELL COUNT; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; LEAD; LEAD POISONING, NERVOUS SYSTEM; NERVE TISSUE PROTEINS; NEUROBLASTOMA; PARASYMPATHETIC NERVOUS SYSTEM; TRYPAN BLUE;

EID: 61949313906     PISSN: 00651400     EISSN: 00651400     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Auld DS, Kar S, Quirion R (1998) β-Amyloid peptides as a direct cholinergic modulators: a missing link? Trends Neurosci 21: 43-49.
2. Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, Lahiri DK, Zawia NH (2005a) The fetal basis of amyloidogenesis: Exposure to lead and latent overexpression of amyloid precursor protein and β-amyloid in the aging brain. J Neurosci 25: 823 - 829.
3. Basha MR, Murali M, Siddiqi HK, Ghosal K, Siddiqi OK, Lashuel HA, Ge YW, Lahiri DK, Zawia NH (2005b) Lead (Pb) exposure and its effect on APP proteolysis and Aβ aggregation. FASEB J 19: 2083 - 2084. doi 10.1096/ fj.05-4375fje
4. Bielarczyk H, Tian X, Suszkiw JB (1996) Cholinergic dennervation-like changes in rat hippocampus following developmental lead exposure. Brain Res 708: 108 - 115.
5. Bielarczyk H, Tomaszewicz M, Szutowicz A (1998) Effect of aluminum on acetyl-CoA and acetylcholine metabolism in nerve terminals. J Neurochem 70: 1175 - 1181.
6. Bielarczyk H, Morozov Y, Suszkiw JB (1999) Regionspecific effects of Pb exposure on central cholinergic and catecholaminergic pathways. Toxicologist 48: 244.
7. Bielarczyk H, Jankowska A, Madziar B, Matecki A, Michno A, Szutowicz A (2003) Differential toxicity of nitric oxide, aluminum, and amyloid-β- peptide in SN56 cholinergic cells from mouse septum. Neurochem Int 42: 323 - 331.
8. Bielarczyk H, Gul S, Ronowska A, Bizon-Zygmańska D, Pawelczyk T, Szutowicz A (2006) RS-α-lipoic acid protects cholinergic cells against sodium nitroprusside and amyloid-β neurotoxicity through restoration of acetyl-CoA level. J Neurochem 98: 1242 - 1251.
9. Bishop GM, Robinson SR (2004) The amyloid paradox: Amyloid-β-metal complexes can be neurotoxic and neuroprotective. Brain Pathol 14: 448 - 452.
10. Bradford M (1976) A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248 - 254.
11. 2+ via protein kinase C inhibits nicotinic cholinergic modulation of synaptic transmission in the hippocampus. J. Pharmacol Exp Therap 311: 700 - 710.
12. Brock M, Nickel AC, Madziar B, Blusztajn JK, Berse B (2007) Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways. Brain Res 1145: 1 - 10.
13. Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE (2005) Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications. Ann Neurol 57: 695 - 703.
14. Davis JM, Otto DA, Weil DE, Grant LE (1990) The comparative developmental neurotoxicity of lead in humans and animals. Neurotoxicol Teratol 12: 215 - 229.
15. Fonnum F (1975) A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem 24: 407 - 409.
16. Garza A, Vega R, Soto E (2006) Cellular mechanisms of lead neurotoxicity. Med Sci Monit 12: 57 - 65.
17. Gil-Bea FJ, Garcia-Alloza M, Dominguez J, Marcos B, Ramirez MJ (2005) Evaluation of cholinergic markers in Alzheimer.s disease and in a model of cholinergic deficit. Neurosci Lett 375: 37 - 41.
18. Hardy J (2006) Has the amyloid cascade hypothesis for Alzheimer.s disease been proved? Curr Alzheimer Res 3: 71 - 73.
19. Heinitz K, Beck M, Schliebs R, Perez-Polo JR (2006) Cholinotoxicity mediated by soluble oligomers of β-amyloid (1-42) differs from cholinotoxic effects of oxidative stress as revealed by gene expression analysis. J Neurochem 98: 1930 - 1945.
20. Hoshi M, Takashima A, Murayama M, Yasutake K, Yoshida N, Ishiguro K, Hoshino T, Imahori K (1997) Nontoxic amyloid β peptide1-42 suppresses acetylcholine synthesis. J Biol Chem 24: 2038 - 2041.
21. Imai T, Kosuge Y, Ishige K, Ito Y (2007) Amyloid β-protein potentiates tunicamycin-induced neuronal death in organotypic hippocampal slice culture. Neuroscience 147: 639 - 651.
22. Isacson O, Seo H, Lin L, Albeck D, Granholm AC (2002) Alzheimer's disease and Down.s syndrome: roles of APP, trophic factors and ACh. Trends Neurosci 25: 79 - 84.
23. Jankowska A, Madziar B, Tomaszewicz M, Szutowicz A (2000) Acute and chronic effects of aluminium on acetyl-CoA and acetylcholine metabolizm in differentiated and nondifferentiated SN56 cholinergic cells. J Neurosci Res 62: 615 - 622.
24. Julka D, Sandhir R, Gill KD (1995) Altered cholinergic metabolism in rat CNS following aluminium exposure: implications on learning performance. J Neurochem 65: 2157 - 2164.
25. 2+ neurotoxicity. In: Handbook of Neurotoxicology. Vol. 1 (Massaro E.J, Ed.). Humana Press, Totowa, NJ, p. 107 - 133.
26. Reddy GR, Devi BC, Chetty CS (2007) Developmental lead neurotoxicity: Alterations in brain cholinergic system. NeuroToxicology 28: 402 - 407.
27. Ronowska A, Gul-Hinc S, Bielarczyk H, Pawelczyk T, Szutowicz A (2007) Effects of zinc on SN56 cholinergic neuroblastoma cells. J Neurochem 103: 972 - 983.
28. Schliebs R, Arendt T (2006) The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J Neural Transm 113: 1625 - 1644.
29. 2+ on acetylcholine release from rat brain synaptosomes. J Neurochem 56: 568 - 574.
30. Sirk D, Zhy Z, Wadia JS, Shulyakova N, Phan N, Fong J, Mills LR (2007) Chronic exposure to sub-lethal betaamyloid (Aβ) inhibits the import of nuclear-encoded proteins to mitochondria in differentiated PC12 cells. J Neurochem 103: 1989 - 2003.
31. Sun X, Tian X, Suszkiw JB (1997) Reduction of vesicular acetylcholine transporter mRNA in the rat septum following lead exposure. NeuroReport 8: 891 - 894.
32. Szutowicz A (2001) Aluminum, NO and nerve growth factor neurotoxicity in cholinergic neurons. J Neurosci Res 66: 1009 - 1018.
33. Szutowicz A, Bielarczyk H (1987) Elimination of CoASH interference from acetyl-CoA assay by maleic anhydride. Anal Biochem 164: 292 - 296.
34. Szutowicz A, Stȩpień M, Piec G (1981) Determination of pyruvate dehydrogenase and acetyl-CoA synthetase activities using citrate synthase. Anal Biochem 115: 81 - 87.
35. Szutowicz A, Bielarczyk H, Gul S, Ronowska A, Pawelczyk T, Jankowska-Kulawy A (2006) Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs. Met Brain Dis 21: 149 - 161.
36. Toscano CD, Guilarte TR (2005) Lead neurotoxicity: From exposure to molecular effects. Brain Res Rev 49: 529 - 554.
37. Wang J, Green PS, Simpkins W (2001) Estradiol protects against ATP depletion, mitochondrial memebrane potential decline and generation of reactive oxygen species induced by 3-nitropropionic acid in SK-N-SH human neuroblastoma cells. J Neurochem 77: 804 - 811.
38. Wang XN, Takata T, Sakurai T, Yokono K (2007) Different effects of monocarboxylates on neuronal survival and β-amyloid toxicity. Eur J Neurosci 26: 2142 - 2150.
39. 2+ channel blockers attenuate β-amyloid peptide toxicity to cortical neurons in culture. J Neurochem 62: 372 - 375.
40. Yun SW, Hoyer S (2000) Effects of low-level lead on glycolytic enzymes and pyruvate dehydrogenase of rat brain in vitro: relevance to sporadic Alzheimer's disease? J Neural Transm 107: 355 - 368.
41. Yun SW, Gartner U, Arendt T, Hoyer S (2000) Increase in vulnerability of middle-aged rat brain to lead by cerebral energy depletion. Brain Res Bull 52: 371 - 378.
42. Zang Q, Bratton GR, Agarwal RK, Calise D, Kugel G, Wan Y, Kumar AM (2003) Lead-induced cell signaling cascades in GT1-7 cells. Brain Res Bull 61: 207 - 217.
43. Zatta P Lucchini R, Rensburg SJ, Taylor A (2003) The role of metals in neurodegenerative processes: aluminum, manganese, and zinc. Brain Res Bull 62: 15 - 28.
44. Zawia NH, Basha MR (2005) Environmental risk factors and the developmental basis for Alzheimer's disease. Rev Neurosci 16: 325 - 337.
45. Zhou M, Tian X, Suszkiw JB (2000) Developmental stagedependent protective effect of NGF against lead cholinotoxicity in the rat septum. Brain Res 866: 268 - 273.