Imaging spontaneous tumorigenesis: Inflammation precedes development of peripheral NK tumors

Blood

Volumn 113, Issue 7, 2009, Pages 1493-1500

  Rauch, Dan ^a   Gross, Shimon ^b   Harding, John ^a   Niewiesk, Stefan ^c   Lairmore, Michael ^c   Piwnica Worms, David ^b,d   Ratner, Lee ^a,d  

^a Division of Molecular Oncology   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; TAX PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CANCER GROWTH; DISEASE COURSE; EARLY DIAGNOSIS; IN VIVO STUDY; LONG TERMINAL REPEAT; LYMPHOCYTE ACTIVATION; MALIGNANT TRANSFORMATION; MOUSE; NATURAL KILLER T CELL; NK T CELL LYMPHOMA; NONHUMAN; PERIPHERAL T CELL LYMPHOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SUBCUTANEOUS TISSUE TUMOR; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION;

EID: 61849168905     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-07-166462     Document Type: Article

References (58)

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57-70.
2. Gross S, Piwnica-Worms D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell. 2005;7:5-15.
3. Matsuoka M, Jeang K-T. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer. 2007;7:270-280.
4. Azran I, Schavinsky-Khrapunsky Y, Aboud M. Role of Tax protein in human T-cell leukemia virus type-1 leukemogenicity. Retrovirology. 2004;1:20-43.
5. Tabakin-Fix Y, Azran I, Schavinky-Khrapunsky Y Levy O, Aboud M. Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications. Carcinogenesis. 2006;27:673-681.
6. Kehn K, Fuente CL, Strouss K, et al. The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation. Oncogene. 2005;20:525-540.
7. Hanson R, Sclar G, Kanagawa O, Ley T. The 5′-flanking region of the human CGL-1/Granzyme B gene targets expression of a reporter gene to activated T-lymphocytes in transgenic mice. J Biol Chem. 1991;266:24433-24438.
8. Grossman WJ, Kimata JT, Wong F-H, Zutter M, Ley TJ, Ratner L. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A. 1995;92:1057-1062.
9. Gao L, Dheng H, Zhao H, Hirbe A, Ratner L, Weilbaecher K. HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone disease prevented by osteoclast inhibiton. Blood. 2005;106: 4294-4302.
10. Grossman W, Ratner L. Cytokine expression in human T-cell leukemia virus tax transgenic leukemia. Blood. 1997;90:783-794.
11. Derse D, Mikovits J, Polivanova M, Felber BK, Ruscetti F. Virions released from cells transfected with a molecular clone of human T-cell leukemia virus type I give rise to primary and secondary infections of Tcells. J Virol. 1995;69:1907-1912.
12. Kimata JT, Ratner L. Temporal regulation of viral and cellular gene expression during HTLV-I mediated lymphocyte immortalization. J Virol. 1991; 65:4398-4407.
13. Delamarre L, Pique C, Pham D, Tursz T Dokhelar M-C. Identification of functional regions in the human T-cell leukemia virus type 1 SU glycoprotein. J Virol. 1994;68:3544-3549.
14. Robek MD, Ratner L. Immortalization of T-lymphocytes by human T-cell leukemia virus type 1 tax mutants with different trans-activating pheno-types. J Virol. 1999;73:4856-4865.
15. Luker GD, Sharma V, Piwnica-Worms D. Visualizing protein-protein interactions in living animals. Methods. 2003;29:110-122.
16. Bernal-Mizrachi L, Lovly CM, Ratner L. The role of nuclear factor-KB-1 and -2-mediated resistance to apoptosis in lymphomas. Proc Natl Acad Sci U S A. 2006;103:9220-9225.
17. Mitra-Kaushik S, Harding J, Hess J, Ratner L. Effects of the proteasome inhibitor, PS-341, on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants. Blood. 2004;104:802-809.
18. Mitra-Kaushik S, Harding J, Hess J, Schreiber R, Ratner L. Enhanced tumorigenesis in HTLV-1 Tax transgenic mice deficient in interferon gamma. Blood. 2004;104:3305-3311.
19. Yin MJ, Paulssen EJ, Seeler JS, Gaynor RB. Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB. J Virol. 1995;69:3420-3432.
20. Robek M, Ratner L. Role of Tax-CBP interaction in HTLV-1 immortalization. J Virol. 2000;74: 11988-11992.
21. Grant C, Jain P, Nonnenmacher M, et al. AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation. J Leukoc Biol. 2006;80:640-650.
22. Grant C, Nonnemacher M, Jain P, et al. CAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation. Virology. 2006;348:354-369.
23. Langlois M, Audet B, Legault E, et al. Activation of HTLV-I gene transcription by protein tyrosine phosphatase inhibitors. Virology. 2004;329:395-411.
24. Livengood JA, Nyborg JK. The high affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression. Nucl Acids Res. 2004;32:2839-2837.
25. Schavinsky-Khrapunsky Y, Gold E, Ben-Aroya Z, Torgeman A, Aboud M, Huleihel M. Activation of HTLV-I long terminal repeat by apoptosis inducing agents: mechanism and implications for HTLV-I pathogenicity. Int J Mol Med. 2003;11:3-11.
26. Torgeman A, Ben-Aroya Z, Grunspan A, et al. Activation of HTLV-I long terminal repeat by stress-inducing agents and protection of HTLV-I-infected T-cells from apoptosis by the viral tax protein. Exp Cell Res. 2001;15:169-179.
27. Torgeman A, Mor-Vaknin N, Aboud M. Sp1 is involved in a protein kinase C-independent activation of human T cell leukemia virus type I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate. Virology. 1999;254:279-287.
28. Torgeman A, MorVaknin N, Zelin E, et al. Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13- acetatethat is antagonized by protein kinase C. Virology. 2001;281:10-20.
29. Forgacs E, Gupta SK, Kerry JA, Semmes OJ. The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. J Virol. 2005;79:6932-6937.
30. Lu H, Pise-Masison CA, Linton R, et al. Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. J Virol. 2004;78:6735-6743.
31. Portis T, Harding JC, Ratner L. The contribution of NF kB activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 (HTLV-1) tax-induced tumors. Blood. 2001;98:1200-1208.
32. Lairmore M, Silverman L, Ratner L. Animal models for HTLV-1 transformation. Oncogene. 2005; 24:6005-6015.
33. Karin M. Nuclear factor-kappa B in cancer development and progression. Nature. 2006;441:431-436.
34. Peloponese JM, Yeung ML, Jeang KT. Modulation of nuclear factor-kappaB by human T-cell leukemia virus type 1 Tax protein: implications for oncogenesis and inflammation. Immunol Res. 2006;34:1-12.
35. Moretta A, Marcenaro E, Parolini S, Feriazzo G, Moretta L. NK cells at the interface between innnate and adaptive immunity. Cell Death Differ. 2008;15:226-233.
36. Kuo YL, Giam CZ. Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence. EMBO J. 2006;25:1741-1752.
37. Liu B, Merling R, Xia Z, Giam CZ. Human T-cell leukemia virus type 1 infection leads to arrest in the G1 phase of the cell cycle. J Virol. 2008;82: 8442-8455.
38. Tripp A, Banerjee P, Sieburg M, Planelles V, Li F Feuer G. Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression. J Virol. 2005;79:14069-14078.
39. Jain P, Mostoller K, Flaig KE, et al. Identification of human T cell leukemia virus type 1 tax amino acid signals and cellular factors involved in secretion of the viral oncoprotein. J Biol Chem. 2007; 282:34581-34593.
40. Marriott SJ, Trinh D, Brady JN. Activation of inter-leukin-2 receptor alpha expression by extracellular HTLV-I Tax1 protein: a potential role in HTLV-I pathogenesis. Oncogene. 1992;7:1749-1755.
41. Grossman W, Ratner L. Transgenic mouse models for HTLV-1 infection. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13(Suppl 1):S162-S169.
42. Kwon H, Ogle L, Benitez B, et al. Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J Biol Chem. 2005;280:35713-35722.
43. Habu K, Nakayama-Yamada J, Asano M, et al. The human T-cell leukemia virus type I-taxgene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice. J Immunol. 1999;162: 2956-2963.
44. Bieberich CJ, King CM, Tinkle BT, Jay G. Atransgenic model of transactivation by the Tax protein of HTLV-I. Virology. 1993;196:309-318.
45. Coscoy L, Gonzalez-Dunia D, Chirinian-Swan S, Brahic M, Ozden S. Analysis of the expression directed by two HTLV-I promoters in transgenic mice. J Neurovirol. 1996;2:336-344.
46. Gonzalez-Dunia D, Grimber G, Briand P, Brahic M, Ozden S. Tissue expression pattern directed in transgenic mice by the LTR of an HTLV-I provirus isolated from a case of tropical spastic paraparesis. Virology. 1992;187:705-710.
47. Green JE, Hinrichs SH, Vogel J, Jay G. Exocrinopathy resembling Sjogren's syndrome in HTLV-1 tax transgenic mice. Nature. 1989;341: 72-74.
48. Inoue JL, Seiki M, Taniguchi T, Tsuru S, Yoshida M. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J. 1986;5:2883-2888.
49. Nerenberg MI, Wiley CA. Degeneration of oxidative muscle fibers in HTLV-1 tax transgenic mice. Am J Pathol. 1989;135:1025-1033.
50. Ruddle NH, Li CB, Horne WC, et al. Mice transgenic for HTLV-I LTR-tax exhibit tax expression in bone, skeletal alterations, and high bone turnover. Virology. 1993;197:196-204.
51. Benvenisty N, Ornitz DM, Bennett GL, et al. Brain tumours and lymphomas in transgenic mice that carry HTLV-I LTR/c-myc and Ig/tax genes. Oncogene. 1992;7:2399-2405.
52. Shinohara T. HTLV-I tax mediated activation of cellular genes in transgenic mice. J Hokkaido Igaku Zasshi. 1991;66:534-543.
53. Hasegawa H, Sawa H, Lewis MJ, et al. Thymus-derived leukemia-lymphomain mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med. 2006;12:466-472.
54. Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res. 2006;4:221-233.
55. Coussens L, Werb Z. Inflammation and cancer. Nature. 2002;420:860-867.
56. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539-545.
57. Karin M, Cao Y, Greten FR, Li ZW. NF-κB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002;2:301-310.
58. Pikarsky E, Porat RM, Stein I, et al. NF-κB functions as a tumor promote in inflammation-associated cancer. Nature. 2004;431:461-466.