The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae

Genetics

Volumn 180, Issue 4, 2008, Pages 2007-2017

  Spitzner, Andrea ^a,b   Perzlmaier, Angelika F ^a   Geillinger, Kerstin E ^a,c   Reihl, Petra ^a,d   Stolz, Jürgen ^a,c  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF STUTTGART   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Hessisches Landeslabor   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; FLAVINE ADENINE NUCLEOTIDE; PROLINE; PROLINE DEHYDROGENASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PUT1; TRANSCRIPTION FACTOR PUT2; TRANSCRIPTION FACTOR PUT3; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SUPPRESSOR GENE; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

BINDING SITES; GENE EXPRESSION REGULATION, FUNGAL; GENETIC COMPLEMENTATION TEST; MODELS, BIOLOGICAL; MONOCARBOXYLIC ACID TRANSPORTERS; PHENOTYPE; PROLINE; PROMOTER REGIONS, GENETIC; RIBOFLAVIN; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUPPRESSION, GENETIC; TRANS-ACTIVATORS;

SACCHAROMYCES CEREVISIAE;

EID: 61849165016     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.108.094458     Document Type: Article

References (47)

1. ANDREASSON, C., E. P. NEVE and P. O. LJUNGDAHL, 2004 Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast. Yeast 21: 193-199.
2. AXELROD, J. D., J. MAJORS and M. C. BRANDRISS, 1991 Proline-independent binding of PUT3 transcriptional activator protein detected by footprinting in vivo. Mol. Cell. Biol. 11: 564-567.
3. BACHER, A., S. EBERHARDT, M. FISCHER, K. KIS and G. RICHTER, 2000 Biosynthesis of vitamin b2 (riboflavin). Annu. Rev. Nutr. 20: 153-167.
4. BOER, V. M., S. L. TAI, Z. VURALHAN, Y. ARIFIN, M. C. WALSH et al., 2007 Transcriptional responses of Saccharomyces cerevisiae to preferred and nonpreferred nitrogen sources in glucose-limited chemostat cultures. FEMS Yeast Res. 7: 604-620.
5. BORETSKY, Y. R., K. Y. KAPUSTYAK, L. R. FAYURA, O. V. STASYK, M. M. STENCHUK et al., 2005 Positive selection of mutants defective in transcriptional repression of riboflavin synthesis by iron in the flavinogenic yeast Pichia guilliermondii. FEMS Yeast Res. 5: 829-837.
6. BRACHMANN, C. B., A. DAVIES, G. J. COST, E. CAPUTO, J. LI et al., 1998 Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14: 115-132.
7. BRANDRISS, M. C., 1987 Evidence for positive regulation of the proline utilization pathway in Saccharomyces cerevisiae. Genetics 117: 429-435.
8. BRANDRISS, M. C., and B. MAGASANIK, 1979 Genetics and physiology of proline utilization in Saccharomyces cerevisiae: mutation causing constitutive enzyme expression. J. Bacteriol. 140: 504-507.
9. BURGESS, C. M., D. J. SLOTBOOM, E. R. GEERTSMA, R. H. DUURKENS, B. POOLMAN et al., 2006 The riboflavin transporter RibU in Lactococcus lactis: molecular characterization of gene expression and the transport mechanism. J. Bacteriol. 188: 2752-2760.
10. BÄSSLER, K.-H., I. GOLLY, D. LOEW and K. PIETRZUK, 2002 Vitamin-Lexikon. Urban & Fischer, München, Jena, Germany.
11. CECCHINI, G., M. PERL, J. LIPSICK, T. P. SINGER and E. B. KEARNEY, 1979 Transport and binding of riboflavin by Bacillus subtilis. J. Biol. Chem. 254: 7295-7301.
12. DES ETAGES, S. A., D. A. FALVEY, R. J. REECE and M. C. BRANDRISS, 1996 Functional analysis of the PUT3 transcriptional activator of the proline utilization pathway in Saccharomyces cerevisiae. Genetics 142: 1069-1082.
13. DES ETAGES, S. A., D. SAXENA, H. L. HUANG, D. A. FALVEY, D. BARBER et al., 2001 Conformational changes play a role in regulating the activity of the proline utilization pathway-specific regulator in Saccharomyces cerevisiae. Mol. Microbiol. 40: 890-899.
14. FORAKER, A. B., C. M. KHANTWAL and P. W. SWAAN, 2003 Current perspectives on the cellular uptake and trafficking of riboflavin. Adv. Drug Deliv. Rev. 55: 1467-1483.
15. GIETZ, R. D., and A. SUGINO, 1988 New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74: 527-534.
16. GODARD, P., A. URRESTARAZU, S. VISSERS, K. KONTOS, G. BONTEMPI et al., 2007 Effect of 21 different nitrogen sources on global gene expression in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 27: 3065-3086.
17. GRILL, S., H. YAMAGUCHI, H. WAGNER, L. ZWAHLEN, U. KUSCH et al., 2007 Identification and characterization of two Streptomyces davawensis riboflavin biosynthesis gene clusters. Arch. Microbiol. 188: 377-387.
18. HARBISON, C. T., D. B. GORDON, T. I. LEE, N. J. RINALDI, K. D. MACISAAC et al., 2004 Transcriptional regulatory code of a eukaryotic genome. Nature 431: 99-104.
19. HUANG, H. L., and M. C. BRANDRISS, 2000 The regulator of the yeast proline utilization pathway is differentially phosphorylated in response to the quality of the nitrogen source. Mol. Cell. Biol. 20: 892-899.
20. ISHCHENKO, A. A., X. YANG, D. RAMOTAR and M. SAPARBAEV, 2005 The 39′ → 59′ exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol. Cell. Biol. 25: 6380-6390.
21. KIS, K., K. KUGELBREY and A. BACHER, 2001 Biosynthesis of riboflavin. The reaction catalyzed by 6,7-dimethyl-8- ribityllumazine synthase can proceed without enzymatic catalysis under physiological conditions. J. Org. Chem. 66: 2555-2559.
22. KOBAYASHI, M., Y. OHARA-NEMOTO, M. KANEKO, H. HAYAKAWA, M. SEKIGUCHI et al., 1998 Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 273: 26394-26399.
23. KOSER, S. A., 1968 Vitamin Requirements of Bacteria and Yeasts. Charles C. Thomas, Springfield, IL.
24. LESUISSE, E., S. A. KNIGHT, M. COUREL, R. SANTOS, J. M. CAMADRO et al., 2005 Genome-wide screen for genes with effects on distinct iron uptake activities in Saccharomyces cerevisiae. Genetics 169: 107-122.
25. MAKUC, J., S. PAIVA, M. SCHAUEN, R. KRAMER, B. ANDRE et al., 2001 The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Yeast 18: 1131-1143.
26. MARCZAK, J. E., and M. C. BRANDRISS, 1989 Isolation of constitutive mutations affecting the proline utilization pathway in Saccharomyces cerevisiae and molecular analysis of the PUT3 transcriptional activator. Mol. Cell. Biol. 9: 4696-4705.
27. MARCZAK, J. E., and M. C. BRANDRISS, 1991 Analysis of constitutive and noninducible mutations of the PUT3 transcriptional activator. Mol. Cell. Biol. 11: 2609-2619.
28. MELCHER, K., B. SHARMA, W. V. DING and M. NOLDEN, 2000 Zero background yeast reporter plasmids. Gene 247: 53-61.
29. NUNOSHIBA, T., R. ISHIDA, M. SASAKI, S. IWAI, Y. NAKABEPPU et al., 2004 A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae. Nucleic Acids Res. 32: 5339-5348.
30. PIRNER, H. M., and J. STOLZ, 2006 Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase. J. Biol. Chem. 281: 12381-12389.
31. REIHL, P., and J. STOLZ, 2005 The monocarboxylate transporter homolog Mch5p catalyzes riboflavin (vitamin B2) uptake in Saccharomyces cerevisiae. J. Biol. Chem. 280: 39809-39817.
32. SAXENA, D., K. B. KANNAN and M. C. BRANDRISS, 2003 Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae. Eukaryot. Cell 2: 552-559.
33. SEKINE, T., A. KAWAGUCHI, Y. HAMANO and H. TAKAGI, 2007 Desensitization of feedback inhibition of the Saccharomyces cerevisiae gamma-glutamyl kinase enhances proline accumulation and freezing tolerance. Appl. Environ. Microbiol. 73: 4011-4019.
34. SELLICK, C. A., and R. J. REECE, 2003 Modulation of transcription factor function by an amino acid: activation of Put3p by proline. EMBO J. 22: 5147-5153.
35. SELLICK, C. A., and R. J. REECE, 2005 Eukaryotic transcription factors as direct nutrient sensors. Trends Biochem. Sci. 30: 405-412.
36. SIDDIQUI, A. H., and M. C. BRANDRISS, 1989 The Saccharomyces cerevisiae PUT3 activator protein associates with proline-specific upstream activation sequences. Mol. Cell. Biol. 9: 4706-4712.
37. SIKORSKI, R. S., and P. HIETER, 1989 A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
38. STAHMANN, K. P., J. L. REVUELTA and H. SEULBERGER, 2000 Three biotechnical processes using Ashbya gossypii, Candida famata, or Bacillus subtilis compete with chemical riboflavin production. Appl. Microbiol. Biotechnol. 53: 509-516.
39. SWAMINATHAN, K., P. FLYNN, R. J. REECE and R. MARMORSTEIN, 1997 Crystal structure of a PUT3-DNA complex reveals a novel mechanism for DNA recognition by a protein containing a Zn2Cys6 binuclear cluster. Nat. Struct. Biol. 4: 751-759.
40. THOMAS, B. J., and R. ROTHSTEIN, 1989 Elevated recombination rates in transcriptionally active DNA. Cell 56: 619-630.
41. TODD, R. B., and A. ANDRIANOPOULOS, 1997 Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet. Biol. 21: 388-405.
42. VITRESCHAK, A. G., D. A. RODIONOV, A. A. MIRONOV and M. S. GELFAND, 2002 Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation. Nucleic Acids Res. 30: 3141-3151.
43. VOGL, C., S. GRILL, O. SCHILLING, J. STÜLKE, M. MACK et al., 2007 Characterization of riboflavin (vitamin B2) transport proteins from Bacillus subtilis and Corynebacterium glutamicum. J. Bacteriol. 189: 7367-7375.
44. WACH, A., A. BRACHAT, R. POHLMANN and P. PHILIPPSEN, 1994 New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10: 1793-1808.
45. WALTERS, K. J., K. T. DAYIE, R. J. REECE, M. PTASHNE and G. WAGNER, 1997 Structure and mobility of the PUT3 dimer. Nat. Struct. Biol. 4: 744-750.
46. WANG, S. S., and M. C. BRANDRISS, 1987 Proline utilization in Saccharomyces cerevisiae: sequence, regulation, and mitochondrial localization of the PUT1 gene product. Mol. Cell. Biol. 7: 4431-4440.
47. YONEZAWA, A., S. MASUDA, T. KATSURA and K. INUI, 2008 Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1. Am. J. Physiol. Cell Physiol. 295: C632-C641.