Modulation of transcription factor function by an amino acid: Activation of Put3p by proline

EMBO Journal

Volumn 22, Issue 19, 2003, Pages 5147-5153

  Sellick, Christopher A ^a   Reece, Richard J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Gene regulation; Genetic switch; In vitro transcription; Proline; Put3p

Indexed keywords

FUNGAL PROTEIN; GLUTAMIC ACID; NITROGEN; PROLINE; PYRROLIDINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; FUNGAL GENE; GENE CONTROL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PUT3P GENE; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

DNA; GENE EXPRESSION REGULATION, FUNGAL; PROLINE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0141865494     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg480     Document Type: Article

References (29)

1. Amar, N., Messenguy, F., El Bakkoury, M. and Dubois, E. (2000) ArgRII, a component of the ArgR-Mcm1 complex involved in the control of arginine metabolism in Saccharomyces cerevisiae, is the sensor of arginine. Mol. Cell. Biol., 20, 2087-2097.
2. Axelrod, J.D., Majors, J. and Brandriss, M.C. (1991) Proline-independent binding of PUT3 transcriptional activator protein detected by footprinting in vivo. Mol. Cell. Biol., 11, 564-567.
3. Brandriss, M.C. (1987) Evidence for positive regulation of proline utilization in Saccharomyces cerevisiae. Genetics, 117, 429-435.
4. Carey, M., Leatherwood, J. and Ptashne, M. (1990) A potent GAL4 derivative activates transcription at a distance in vitro. Science, 247, 710-712.
5. des Etages, S.G., Falvey, D.A., Reece, R.J. and Brandriss, M.C. (1996) Functional analysis of the PUT3 transcriptional activator of the proline utilization pathway in Saccharomyces cerevisiae. Genetics, 142, 1069-1082.
6. des Etages, S.G., Saxena, D., Huang, H.L., Falvey, D.A., Barber, D. and Brandriss, M.C. (2001) Conformational changes play a role in regulating the activity of the proline utilization pathway-specific regulator in Saccharomyces cerevisiae. Mol. Microbiol., 40, 890-899.
7. Flynn, P.J. and Reece, R.J. (1999) Activation of transcription by metabolic intermediates of the pyrimidine biosynthetic pathway. Mol. Cell. Biol., 19, 882-888.
8. Giniger, E. and Ptashne, M. (1987) Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit. Nature, 330, 670-672.
9. Huang, H.L. and Brandriss, M.C. (2000) The regulator of the yeast proline utilization pathway is differentially phosphorylated in response to the quality of the nitrogen source. Mol. Cell. Biol., 20, 892-899.
10. Kammerer, B., Guyonvarch, A. and Hubert, J.C. (1984) Yeast regulatory gene PPR1. I. Nucleotide sequence, restriction map and codon usage. J. Mol. Biol., 180, 239-250.
11. Krzywicki, K.A. and Brandriss, M.C. (1984) Primary structure of the nuclear PUT2 gene involved in the mitochondrial pathway for proline utilization in Saccharomyces cerevisiae. Mol. Cell. Biol., 4, 2837-2842.
12. Marczak, J.E. and Brandriss, M.C. (1989) Isolation of constitutive mutations affecting the proline utilization pathway in Saccharomyces cerevisiae and molecular analysis of the PUT3 transcriptional activator. Mol. Cell. Biol., 9, 4696-4705.
13. Marczak, J.E. and Brandriss, M.C. (1991) Analysis of constitutive and noninducible mutations of the PUT3 transcriptional activator. Mol. Cell. Biol., 11, 2609-2619.
14. Ohashi, Y., Brickman, J.M., Furman, E., Middleton, B. and Carey, M. (1994) Modulating the potency of an activator in a yeast in vitro transcription system. Mol. Cell. Biol., 14, 2731-2739.
15. Peng, G. and Hopper, J.E. (2002) Gene activation by interaction of an inhibitor with a cytoplasmic signaling protein. Proc. Natl. Acad. Sci. USA, 99, 8548-8553.
16. Platt, A. and Reece, R.J. (1998) The yeast galactose genetic switch is mediated by the formation of a Ga14p/Ga180p/Ga13p complex. EMBO J., 17, 4086-4091.
17. Platt, A., Ross, H.C., Hankin, S. and Reece, R.J. (2000) The insertion of two amino acids into a transcriptional inducer converts it into a galactokinase. Proc. Natl Acad. Sci. USA, 97, 3154-3159.
18. Reece, R.J. (2000) Molecular basis of nutrient controlled gene expression in Saccharomyces cerevisiae. Cell. Mol. Life Sci., 57, 1161-1171.
19. 6 zinc cluster proteins. Science, 261, 909-911.
20. Saxena, D., Kannan, K.B. and Brandriss, M.C. (2003) Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae. Eukaryot. Cell, 2, 552-559.
21. Siddiqui, A.H. and Brandriss, M.C. (1988) A regulatory region responsible for proline-specific induction of the yeast PUT2 gene is adjacent to its TATA box. Mol. Cell. Biol., 8, 4634-4641.
22. Siddiqui, A.H. and Brandriss, M.C. (1989) The Saccharomyces cerevisiae PUT3 activator protein associates with proline-specific upstream activation sequences. Mol. Cell. Biol., 9, 4706-4712.
23. Studier, F.W., Rosenberg, A.H., Dunn, J.J. and Dubendorff, J.W. (1990) Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol., 185, 60-89.
24. 6 binuclear cluster. Nat. Struct. Biol., 4, 751-759.
25. Sze, J.-Y., Woontner, M., Jaehning, J.A. and Kohlhaw, G.B. (1992) In vitro transcriptional activation by a metabolic derivative: activation of Leu3 depends on α-isopropylmalate. Science, 258, 1143-1145.
26. Walters, K.J., Dayie, K.T., Reece, R.J., Ptashne, M. and Wagner, G. (1997) Structure and mobility of the PUT3 dimer: a DNA pincer. Nat. Struct. Biol., 4, 744-750.
27. Wang, D., Zheng, F., Holmberg, S. and Kohlhaw, G.B. (1999) Yeast transcriptional regulator Leu3p. Self-masking, specificity of masking and evidence for regulation by the intracellular level of Leu3p. J. Biol. Chem., 274, 19017-19024.
28. Wang, S.S. and Brandriss, M.C. (1987) Proline utilization in Saccharomyces cerevisiae: sequence, regulation and mitochondrial localization of the PUT1 gene product. Mol. Cell. Biol., 7, 4431-4440.
29. Zenke, F.T., Engles, R., Vollenbroich, V., Meyer, J., Hollenberg, C.P. and Breunig, K.D. (1996) Activation of Ga14p by galactose-dependent interaction of galactokinase and Ga180p. Science, 272, 1662-1665.