Gender-related differences in MS: A study of conventional and nonconventional MRI measures

Multiple Sclerosis

Volumn 15, Issue 3, 2009, Pages 345-354

  Antulov, R ^a,b   Weinstock Guttman, B ^c   Cox, J L ^a   Hussein, S ^a   Durfee, J ^a   Caiola, C ^a   Dwyer, M G ^a   Bergsland, N ^a   Abdelrahman, N ^a   Stosic, M ^a   Hojnacki, D ^a,c   Munschauer, F E ^a   Miletic, D ^b   Zivadinov, R ^a,c  

^a UNIVERSITY AT BUFFALO   (United States)

^b KBC RIJEKA   (Croatia)

^c JACOBS NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Gender; Gray matter atrophy; Multiple sclerosis; Sex hormones; White matter atrophy

Indexed keywords

BETA INTERFERON; BETA1A INTERFERON; GLATIRAMER; IMMUNOGLOBULIN; INTERFERON; INTERFERON BETA SERINE; METHOTREXATE; MITOXANTRONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ADD ON THERAPY; ADULT; AGED; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CLINICALLY ISOLATED SYNDROME; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE DURATION; FEMALE; GRAY MATTER; HUMAN; HUMAN TISSUE; LATERAL BRAIN VENTRICLE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; RECURRENT DISEASE; SEX DIFFERENCE; WHITE MATTER;

ADULT; AGED; AGED, 80 AND OVER; ATROPHY; BRAIN; FEMALE; GONADAL STEROID HORMONES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; NERVE FIBERS, MYELINATED; SEX CHARACTERISTICS; YOUNG ADULT;

EID: 61849129245     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458508099479     Document Type: Article

References (50)

1. Whitacre CC Reingold SC O'Looney PA. A gender gap in autoimmunity. Science 1999; 283: 1277-1278.
2. Hawkins SA McDonnell GV. Benign multiple sclerosis? clinical course, long term follow up, and assessment of prognostic factors. J Neurol Neurosurg Psychiatry 1999; 67: 148-152.
3. Confavreux C Hutchinson M Hours M Cortinovis-Tourniaire P Moreau T. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in multiple sclerosis group. N Engl J Med 1998; 339: 285-291.
4. Kantarci O Siva A Eraksoy M. Survival and predictors of disability in Turkish MS patients. Turkish Multiple Sclerosis Study Group (TUMSSG). Neurology 1998; 51: 765-772.
5. Pozzilli C Tomassini V Marinelli F Paolillo A Gasperini C Bastianello S. 'Gender gap' in multiple sclerosis: Magnetic resonance imaging evidence. Eur J Neurol 2003; 10: 95-97.
6. Li DK Zhao GJ Paty DW. Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI results. Neurology 2001; 56: 1505-1513.
7. van Walderveen MA Lycklama ANGJ Ader HJ. Hypointense lesions on T1-weighted spin-echo magnetic resonance imaging: Relation to clinical characteristics in subgroups of patients with multiple sclerosis. Arch Neurol 2001; 58: 76-81.
8. Weatherby SJ Mann CL Davies MB. A pilot study of the relationship between gadolinium-enhancing lesions, gender effect and polymorphisms of antioxidant enzymes in multiple sclerosis. J Neurol 2000; 247: 467-470.
9. Rovaris M Gass A Bammer R. Diffusion MRI in multiple sclerosis. Neurology 2005; 65: 1526-1532.
10. Horsfield MA. Magnetization transfer imaging in multiple sclerosis. J Neuroimaging 2005; 15: 58S-67S.
11. Zivadinov R Reder AT Filippi M. Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis. Neurology 2008; 71: 136-144.
12. Good CD Johnsrude IS Ashburner J Henson RN Friston KJ Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14: 21-36.
13. Zivadinov R. Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis ? Neurology 2007; 68: S72-S82.
14. Pirko I Lucchinetti CF Sriram S Bakshi R. Gray matter involvement in multiple sclerosis. Neurology 2007; 68: 634-642.
15. Cosgrove KP Mazure CM Staley JK. Evolving knowledge of sex differences in brain structure, function, and chemistry. Biol Psychiatry 2007; 62: 847-855.
16. Allen JS Damasio H Grabowski TJ Bruss J Zhang W. Sexual dimorphism and asymmetries in the gray-white composition of the human cerebrum. Neuroimage 2003; 18: 880-894.
17. Good CD Johnsrude I Ashburner J Henson RN Friston KJ Frackowiak RS. Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 2001; 14: 685-700.
18. Polman CH Reingold SC Edan G. Diagnostic criteria for multiple sclerosis: 2005 revisions to the 'McDonald Criteria'. Ann Neurol 2005; 58: 840-846.
19. Lublin FD Reingold SC. Defining the clinical course of multiple sclerosis: Results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996; 46: 907-911.
20. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 1983; 33: 1444-1452.
21. Zivadinov R Rudick RA De Masi R. Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS. Neurology 2001; 57: 1239-1247.
22. Zivadinov R Bagnato F Nasuelli D. Short-term brain atrophy changes in relapsing-remitting multiple sclerosis. J Neurol Sci 2004; 223: 185-193.
23. Smith SM Zhang Y Jenkinson M. Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 2002; 17: 479-489.
24. Benedict R Bruce J Dwyer M Abderlahman N Zivadinov R. Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis. Arch Neurol 2006; 63: 1301-1306.
25. Tavazzi E Dwyer MG Weinstock-Guttman B. Quantitative diffusion weighted imaging measures in patients with multiple sclerosis. Neuroimage 2007; 36: 746-754.
26. Zivadinov R Weinstock-Guttman B Benedict R. Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor. Hum Mol Genet 2007; 16: 2659-2668.
27. Kutzelnigg A Lucchinetti CF Stadelmann C. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 2005; 128: 2705-2712.
28. Dutta R Trapp BD. Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology 2007; 68: S22-S31 [discussion S43-S54].
29. Magliozzi R Howell O Vora A. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007; 130: 1089-1104.
30. Peeva E Zouali M. Spotlight on the role of hormonal factors in the emergence of autoreactive B-lymphocytes. Immunol Lett 2005; 101: 123-143.
31. Kanda N Tsuchida T Tamaki K. Testosterone suppresses anti-DNA antibody production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1703-1711.
32. Sicotte NL Giesser BS Tandon V. Testosterone treatment in multiple sclerosis: A pilot study. Arch Neurol 2007; 64: 683-688.
33. Patwardhan AJ Eliez S Bender B Linden MG Reiss AL. Brain morphology in Klinefelter syndrome: Extra X chromosome and testosterone supplementation. Neurology 2000; 54: 2218-2223.
34. Cutter WJ Daly EM Robertson DM. Influence of X chromosome and hormones on human brain development: A magnetic resonance imaging and proton magnetic resonance spectroscopy study of Turner syndrome. Biol Psychiatry 2006; 59: 273-283.
35. Tomassini V Onesti E Mainero C. Sex hormones modulate brain damage in multiple sclerosis: MRI evidence. J Neurol Neurosurg Psychiatry 2005; 76: 272-275.
36. Tomassini V Pozzilli C. Sex hormones: A role in the control of multiple sclerosis ? Expert Opin Pharmacother 2006; 7: 857-868.
37. Sicotte NL Liva SM Klutch R. Treatment of multiple sclerosis with the pregnancy hormone estriol. Ann Neurol 2002; 52: 421-428.
38. Wegmann TG Lin H Guilbert L Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon ? Immunol Today 1993; 14: 353-356.
39. Pozzilli C Falaschi P Mainero C. MRI in multiple sclerosis during the menstrual cycle: Relationship with sex hormone patterns. Neurology 1999; 53: 622-624.
40. van Walderveen MA Tas MW Barkhof F. Magnetic resonance evaluation of disease activity during pregnancy in multiple sclerosis. Neurology 1994; 44: 327-329.
41. Gregg C Shikar V Larsen P. White matter plasticity and enhanced remyelination in the maternal CNS. J Neurosci 2007; 27: 1812-1823.
42. Nguyen LT Ramanathan M Weinstock-Guttman B Baier M Brownscheidle C Jacobs LD. Sex differences in in vitro pro-inflammatory cytokine production from peripheral blood of multiple sclerosis patients. J Neurol Sci 2003; 209: 93-99.
43. Moldovan IR Cotleur AC Zamor N Butler RS Pelfrey CM. Multiple sclerosis patients show sexual dimorphism in cytokine responses to myelin antigens. J Neuroimmunol 2008; 193: 161-169.
44. Tiberio M Chard DT Altmann DR. Gray and white matter volume changes in early RRMS: A 2-year longitudinal study. Neurology 2005; 64: 1001-1007.
45. Horakova D Cox JL Havrdova E. Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years. A case control study. J Neurol Neurosurg Psychiatry 2008; 79: 407-414.
46. Redmond IT Barbosa S Blumhardt LD Roberts N. Short-term ventricular volume changes on serial MRI in multiple sclerosis. Acta Neurol Scand 2000; 102: 99-105.
47. Zivadinov R Bakshi R. Role of MRI in multiple sclerosis II: Brain and spinal cord atrophy. Front Biosci 2004; 9: 647-664.
48. Wolinsky JS Narayana PA O'Connor P. Glatiramer acetate in primary progressive multiple sclerosis: Results of a multinational, multicenter, double-blind, placebo-controlled trial. Ann Neurol 2007; 61: 14-24.
49. Sarchielli P Zaffaroni M Floridi A. Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-{beta} 1a, and high doses of immunoglobulins. Mult Scler 2007; 13: 313-331.
50. Weinstock-Guttman B Zivadinov R Tamano-Blanco M. Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis. J Neuroimmunol 2007; 188: 167-174.