Signals regulating neurotrophin expression in glial cells

Progress in Brain Research

Volumn 132, Issue , 2001, Pages 545-554

  Otten, U ^a   Marz P ^a   Heese, K ^c   Hock, C ^d   Kunz, D ^a   Rose John, S ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; COMPLEMENT COMPONENT C3A; CYCLOSPORIN A; CYTOKINE; INTERLEUKIN 6; NEUROTROPHIN; RNA; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA;

CELL ACTIVATION; CELL POPULATION; GLIA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; TUMOR PROMOTION;

EID: 0035783944     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(01)32102-7     Document Type: Article

References (43)

1. Barbacid, M. (1995) Neurotrophic factors and their receptors. Curr. Opin. Cell Biol., 7: 148-155.
2. Besser, M. and Wank, R. (1999) Clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors. J. Immunol., 162: 6303-6306.
3. Braun, A., Appel, E., Baruch, R., Heiz, U., Botchkateo, V., Paus, R., Brodie, C. and Renzu, H. (1998) Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur. J. Immunol., 28: 3240-3251.
4. Bürgi, B., Otten, U., Ochensberger, B., Ribs, S., Heese, K., Ehrhard, P.B., Ibanez, C.F. and Dahinden, C.A. (1996) Basophil priming by neurotrophic factors - Activation through the trk receptor. J. Immunol., 157: 5582-5588.
5. Chao, M.V. and Hempstead, B.L. (1995) p75 and Trk: A two-receptor system. Trends Neurosci., 18: 321-326.
6. Ehrhard, P.B., Erb, P., Graumann, U. and Otten, U. (1993a) Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones. Proc. Natl. Acad Sci. USA, 90: 10984-10988.
7. Ehrhard, P.B., Ganter, U., Stalder, A., Bauer, J. and Otten, U. (1993b) Expression of functional trk protooncogene in human monocytes. Proc. Natl. Acad. Sci. USA, 90: 5423-5427.
8. Eikelenboom, P. and Veerhuis, R. (1996) The role of complement and activated microglia in the pathogenesis of Alzheimer's disease. Neurobiol. Aging, 17: 673-680.
9. Fahnestock, M., Scott, S.A., Jette, N., Weingartner, J.A. and Crutcher, K.A. (1996) Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex. Mol. Brain Res., 42: 175-178.
10. Gadient, R.A. and Otten, U. (1997) Interleukin-6 - A molecule with both beneficial and destructive potentials. Prog. Neurobiol., 52: 379-390.
11. Giulian, D. (1992) Microglia and disease of the nervous system. Curr. Neurol., 12: 23-54.
12. Goedert, M., Fine, A., Hunt, S.P. and Ullrich, A. (1986) Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease. Brain Res., 387: 85-92.
13. Heese, K. and Otten, U. (1998) Complement protein C3a induces neurotrophin expression in human microglial cells. Neural Notes, III(3): 21-23.
14. 2a-receptors. Neurosci. Lett., 231: 83-86.
15. Heese, K., Hock, C. and Otten, U. (1998) Inflammatory signals induce neurotrophin expression in human microglial cells. J. Neurochem., 70: 699-707.
16. Hirota, H., Kiyama, H., Kishimoto, T. and Taga, T. (1996) Accelerated nerve regeneration in mice by upregulated expression of IL-6 and IL-6 receptor after trauma. J. Exp. Med., 183: 2627-2634.
17. Hock, C., Heese, K., Mtiller-Spahn, F., Hulette, C., Rosenberg, C. and Otten, U. (1998) Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease. Neurosci. Lett., 241: 151-154.
18. Hock, C., Heese, K., Müller-Spahn, F., Huber, P., Riesen, W., Nitsch, R.M. and Otten, U. (2000a) Increased cerebrospinal fluid levels of nerve growth factor (NGF) in patients with Alzheimer's disease. Neurology, 54: 2009-2011.
19. Hock, C., Heese, K., Müller-Spahn, F., Huber, P., Riesen, W., Nitsch, R.M. and Otten, U. (2000b) Increased cerebrospinal fluid levels of neurotrophin 3 (NT-3) in elderly patients with major depression. Mol. Psychiatry, 5: 510-513.
20. Hock, C., Heese, K., Hulette, C., Rosenberg, C. and Otten, U. (2000c) Region specific neurotrophin imbalances in Alzheimer's disease: Decreased levels of BDNF and increased levels of NGF in hippocampus and cortical areas. Arch. Neurol. 57, 846-851.
21. Ikeda, K., Kinoshita, M., Tagaya, N., Shiojima, T., Taga, T., Yasukawa, K., Suzuki, H. and Okano, A. (1996) Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor delays progression of wobbler mouse motor neuron disease. Brain Res., 726: 91-97.
22. Kaplan, D.R. and Miller, F. (1997) Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol., 9: 213-221.
23. Kerschensteiner, M., Gallmeier, E., Behrens, L., Leal, V.V., Misgeld, T., Klinkert, W.E., Kolbeck, R., Hoppe, E., OropezaWekerle, R.L., Bartke, I., Stadelmann, C., Lassmann, H., Wekerle, H. and Hohlfeld, R. (1999) Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?. J. Exp. Med., 189: 865-870.
24. Klein, M.A., Möller, J.C., Jones, L.L., Blüthmann, H., Kreutzberg, G.W. and Raivich, G. (1997) Impaired neuroglial activation in IL-6 deficient mice. Glia, 19: 227-233.
25. Kramer, R., Zhang, Y., Gehrmann, J., Gold, R., Thoenen, H. and Wekerle, H. (1995) Gene transfer through the bloodnerve barrier: Nerve growth factor engineered neuritogenic T lymphocytes attenuate experimental autoimmune neuritis. Nat. Med., 1: 1162-1166.
26. Kreutzberg, G.W. (1996) Microglia: A sensor for pathological events in the CNS. Trends Neurosci., 19: 312-318.
27. Leon, A., Burani, A., Dal Toso, R., Fabris, M., Romonello, S., Aloe, L. and Levi-Montalcini, R. (1994) Mast cells synthesize, store, and release nerve growth factor. Proc. Natl. Acad. Sci. USA, 91: 3739-3743.
28. Levi-Montalcini, R., Skaper, S.D., Dal Toso, R., Petrelli, L. and Leon, A. (1996) Nerve growth factor: From neurotrophin to neurokine. Trends Neurosci., 19: 514-520.
29. März, P., Otten, U. and Rose-John, S. (1999a) Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors. Eur. J. Neurosci., 11: 2995-3004.
30. März, P., Heese, K., Dimitriades-Schmutz, B., Rose-John, S. and Otten, U. (1999b) Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. Glia, 26: 191-200.
31. März, P., Oezbek, S., Fischer, M., Voltz, N., Otten, U. and Rose-John, S. (2000) Neuron-specific activity of a new highly active fusion protein of ciliary neurotrophic factor (CNTF) and soluble CNTF receptor (Hyper-CNTF). Abstract FENS-Meeting June, 2000, Brighton, UK.
32. McGeer, P.L. and McGeer, E.G. (1995) The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev., 21: 195-218.
33. Merrill, J.E. and Benveniste, E.N. (1996) Cytokines in inflammatory brain lesions: Helpful and harmful. Trends Neurosci., 19: 331-338.
34. Narisawa-Saito, M., Wakabayashi, K., Tsji, S., Takahashi, H. and Nawa, H. (1996) Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. NeuroReport, 7: 2925-2928.
35. Neumann, H., Misgeld, T., Matsumuro, K. and Wekerle, H. (1998) Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor. Proc. Natl. Acad. Sci. USA, 95: 5779-5784.
36. Oh, J.W., Van Wagoner, N.J., Rose-John, S. and Benveniste, E.N. (1998) Role of IL-6 and soluble IL-6 receptor in inhibition of VCAM-1 gene expression. J. Immunol., 161: 4992-4999.
37. Otten, U. and Gadient, R.A. (1995) Neurotrophins and cytokines - Intermediaries between the immune and nervous systems. Int. J. Dev. Neurosci., 13: 147-151.
38. Phillips, H.S., Hains, J.M., Armanini, M., Laramee, G.R., Johnson, S.A. and Winslow, J.W. (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron, 7: 695-702.
39. Rose-John, S. and Heinrich, P.C. (1994) Soluble receptors for cytokines and growth factors: Generation and biological function. Biochem. J., 300: 281-290.
40. Scott, S.A., Mufson, E.J., Weingartner, J.A., Shau, K.A. and Crutcher, K.A. (1995) Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis. J. Neurosci., 15: 6213-6221.
41. Taga, T. and Kishimoto, T. (1997) gpl30 and the interleukin-6 family of cytokines. Annu. Rev. Immunol., 15: 797-819.
42. Torcia, M., Bracci-Laudiero, L., Lucibello, M., Nencioni, L., Labardi, D., Rubartelli, A., Cozzolino, F., Aloe, L. and Garaci, E. (1996) Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Cell, 85: 345-356.
43. Unger, J.W. (1999) Glial reaction in aging and Alzheimer's disease. Microsc. Res. Tech., 43: 24-28.