Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres

Human Molecular Genetics

Volumn 18, Issue 6, 2009, Pages 1017-1027

  Muntoni, Alessandra ^a,b   Neumann, Axel A ^a,b   Hills, Mark ^c   Reddel, Roger R ^a,b  

^a CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYGROMYCIN B; PLASMID DNA; RED FLUORESCENT PROTEIN; TELOMERASE; TRIOSEPHOSPHATE ISOMERASE;

ALTENATIVE LENGTHENING OF TELOMERE; ARTICLE; CELL CLONE; CELL SELECTION; CELL STRAIN; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DNA REPLICATION; DNA SEQUENCE; DNA TEMPLATE; FLUORESCENCE ACTIVATED CELL SORTING; GENE AMPLIFICATION; GENE CONSTRUCT; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TELOMERE;

BASE SEQUENCE; CLONE CELLS; DNA REPLICATION; GENE DUPLICATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; PLASMIDS; POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; TELOMERE; TRANSFECTION;

EID: 61849103618     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddn436     Document Type: Article

References (31)

1. Yeager, T.R., Neumann, A.A., Englezou, A., Huschtscha, L.I., Noble, J.R. and Reddel, R.R. (1999) Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res., 59, 4175-4179.
2. Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S. and Reddel, R.R. (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J., 14, 4240-4248.
3. Murnane, J.P., Sabatier, L., Marder, B.A. and Morgan, W.F. (1994) Telomere dynamics in an immortal human cell line. EMBO J., 13 4953-4962.
4. Perrem, K., Colgin, L.M., Neumann, A.A., Yeager, T.R. and Reddel, R.R. (2001) Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol. Cell. Biol., 21, 3862-3875.
5. Dunham, M.A., Neumann, A.A., Fasching, C.L. and Reddel, R.R. (2000) Telomere maintenance by recombination in human cells. Nat. Genet., 26, 447-450.
6. Varley, H., Pickett, H.A., Foxon, J.L., Reddel, R.R. and Royle, N.J. (2002) Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells. Nat. Genet., 30, 301-305.
7. Griffith, J.D., Comeau, L., Rosenfield, S., Stansel, R.M., Bianchi, A., Moss, H. and de Lange, T. (1999) Mammalian telomeres end in a large duplex loop. Cell, 97, 503-514.
8. Londono-Vallejo, J.A., Der-Sarkissian, H., Cazes, L., Bacchetti, S. and Reddel, R.R. (2004) Alternative lengthening of telomeres is characterized by high rates of telomeric exchange. Cancer Res., 64, 2324-2327.
9. Bechter, O.E., Shay, J.W. and Wright, W.E. (2004) The frequency of homologous recombination in human ALT cells. Cell Cycle, 3, 547-549.
10. Bailey, S.M., Brenneman, M.A. and Goodwin, E.H. (2004) Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res., 32, 3743-3751.
11. Tokutake, Y., Matsumoto, T., Watanabe, T., Maeda, S., Tahara, H., Sakamoto, S., Niida, H., Sugimoto, M., Ide, T. and Furuichi, Y. (1998) Extra-chromosome telomere repeat DNA in telomerase-negative immortalized cell lines. Biochem. Biophys. Res. Commun., 247, 765-772.
12. Ogino, H., Nakabayashi, K., Suzuki, M., Takahashi, E.I., Fujii, M., Suzuki, T. and Ayusawa, D. (1998) Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity. Biochem. Biophys. Res. Commun., 248, 223-227.
13. Cesare, A.J. and Griffith, J.D. (2004) Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous T-loops. Mol. Cell. Biol., 24, 9948-9957.
14. Wang, R.C., Smogorzewska, A. and de Lange, T. (2004) Homologous recombination generates T-loop-sized deletions at human telomeres. Cell, 119, 355-368.
15. Fasching, C.L., Neumann, A.A., Muntoni, A., Yeager, T.R. and Reddel, R.R. (2007) DNA damage induces alternative lengthening of telomeres (ALT) associated promyelocytic leukemia bodies that preferentially associate with linear telomeric DNA. Cancer Res., 67, 7072-7077.
16. Azzalin, C.M., Reichenback, P., Khoriauli, L., Giulotto, E. and Lingner, J. (2007) Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science, 318, 798-801.
17. INK#14 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol. Cell. Biol., 15, 4745-4753.
18. Muntoni, A. and Reddel, R.R. (2005) The first molecular details of ALT in human tumor cells. Hum. Mol. Genet., 14 (Suppl. 2), R191-R196.
19. Blagoev, K.B. and Goodwin, E.H. (2008) Telomere exchange and asymmetric segregation of chromosomes can account for the unlimited proliferative potential of ALT cell populations. DNA Repair (Amst.), 7, 199-204.
20. Stansel, R.M., de Lange, T. and Griffith, J.D. (2001) T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J., 20, 5532-5540.
21. Chai, W., Shay, J.W. and Wright, W.E. (2005) Human telomeres maintain their overhang length at senescence. Mol. Cell. Biol., 25, 2158-2168.
22. Gottschling, D.E., Aparicio, O.M., Billington, B.L. and Zakian, V.A. (1990) Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription. Cell, 63, 751-762.
23. Sandell, L.L. and Zakian, V.A. (1992) Telomeric position effect in yeast. Trends Cell Biol., 2, 10-14.
24. Sprung, C.N., Sabatier, L. and Murnane, J.P. (1996) Effect of telomere length on telomeric gene expression. Nucleic Acids Res., 24, 4336-4340.
25. Baur, J.A., Zou, Y., Shay, J.W. and Wright, W.E. (2001) Telomere position effect in human cells. Science, 292, 2075-2077.
26. Koering, C.E., Pollice, A., Zibella, M.P., Bauwens, S., Puisieux, A., Brunori, M., Brun, C., Martins, L., Sabatier, L., Pulitzer, J.F. and Gilson, E. (2002) Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep., 3, 1055-1061.
27. Gao, Q., Reynolds, G.E., Innes, L., Pedram, M., Jones, E., Junabi, M., Gao, D.W., Ricoul, M., Sabatier, L., Van Brocklin, H. et al. (2007) Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts, but are expressed in embryonic stem cells. Stem Cells, 25, 3085-3092.
28. Luke, B., Panza, A., Redon, S., Iglesias, N., Li, Z. and Lingner, J. (2008) The Rat1p 5′ to 3′ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol. Cell, 32, 465-477.
29. Natarajan, S. and McEachern, M.J. (2002) Recombinational telomere elongation promoted by DNA circles. Mol. Cell. Biol., 22, 4512-4521.
30. Bucholc, M., Park, Y. and Lustig, A.J. (2001) Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae. Mol. Cell. Biol., 21, 6559-6573.
31. Topcu, Z., Nickles, K., Davis, C. and McEachern, M.J. (2005) Abrupt disruption of capping and a single source for recombinationally elongated telomeres in Kluyveromyces lactis. Proc. Natl Acad. Sci. USA, 102, 3348-3353.