Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain

NeuroToxicology

Volumn 30, Issue 2, 2009, Pages 274-280

  Schuh, Rosemary A ^a   Richardson, Jason R ^b   Gupta, Rupesh K ^c   Flaws, Jodi A ^c   Fiskum, Gary ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UMDNJ/RWJMS and EOHSI   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Complex I; Dopamine; Dopamine transporter; Methoxychlor; Mitochondria; Neurodegeneration; Oxidative stress; Parkinson's disease; Vesicular monoamine transporter 2

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; DOPAMINE; DOPAMINE TRANSPORTER; HOMOVANILLIC ACID; METHOXYCHLOR; MITOCHONDRIAL PROTEIN; VESICULAR MONOAMINE TRANSPORTER 2; CARRIER PROTEIN; CHLORINATED HYDROCARBON; PESTICIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC SYSTEM; DOSE RESPONSE; FEMALE; MITOCHONDRION; MOUSE; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN CARBONYLATION; WESTERN BLOTTING; ANIMAL; BRAIN; COMPARATIVE STUDY; DRUG EFFECTS; METABOLISM; TOXICITY;

ANIMALS; BRAIN; DOPAMINE; FEMALE; HYDROCARBONS, CHLORINATED; MEMBRANE TRANSPORT PROTEINS; METHOXYCHLOR; MICE; PESTICIDES;

MUS; SESAMUM INDICUM;

EID: 61849099396     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2008.12.015     Document Type: Article

References (44)

1. Ascherio A., Chen H., Weisskopf M.G., O'Reilly E., McCullough M.L., Calle E.E., et al. Pesticide exposure and risk for Parkinson's disease. Ann Neurol 60 2 (2006) 197-203
2. ATSDR (Agency for Toxic Substances and Disease Registry). Toxicological profile for DDT, DDE, and DDD. U.S. Dept. of Health and Human Services-Public Health Service 2002; http://www.atsdr.cdc.gov/toxprofiles/phs35.html.
3. BenMoyal-Segal L., and Soreq H. Gene-environment interactions in sporadic Parkinson's disease. J Neurochem 97 (2006) 1740-1755
4. Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., and Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3 12 (2000) 1301-1306
5. Brooks D.J., Frey K.A., Marek K.L., Oakes D., Paty D., Prentice R., et al. Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease. Exp Neurol 184 Suppl. 1 (2003) S68-79
6. Brown T.P., Rumsby P.C., Capleton A.C., Rushton L., and Levy L.S. Pesticides and Parkinson's disease-is there a link?. Environ Health Perspect 114 2 (2006) 156-164
7. Caudle W.M., Richardson J.R., Delea K.C., Guillot T.S., Wang M., Pennell K.D., et al. Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to Parkinson's disease-associated dopamine toxicity. Toxicol Sci 92 (2006) 490-499
8. Corrigan F.M., Wienburg C.L., Shore R.F., Daniel S.E., and Mann D. Organochlorine insecticides in substantia nigra in Parkinson's disease. J Toxicol Environ Health A 59 4 (2000) 229-234
9. Eyerman D.J., and Yamamoto B.K. A rapid oxidation and persistent decrease in the vesicular monoamine transporter 2 after methamphetamine. J Neurochem 103 3 (2007) 1219-1227
10. Ferreira F.M., Madeira V.M., and Moreno A.J. Interactions of 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene with mitochondrial oxidative phosphorylation. Biochem Pharmacol 53 3 (1997) 299-308
11. Fiskum G., Starkov A., Polster B., and Chinopoulos C. Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease. Ann NY Acad Sci 991 (2003) 111-119
12. Frigerio R., Sanft K.R., Grossardt B.R., Peterson B.J., Elbaz A., Bower J.H., et al. Chemical exposures and Parkinson's disease: a population-based case-control study. Mov Disord 21 10 (2006) 1688-1692
13. Giros B., Jaber M., Jones S.R., Wightman R.M., and Caron M.G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379 6566 (1996) 606-612
14. Gupta R.K., Schuh R.A., Fiskum G., and Flaws J.A. Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary. Toxicol Appl Pharmacol 216 3 (2006) 436-445
15. Hatcher J.M., Delea K.C., Richardson J.R., Pennell K.D., and Miller G.W. Disruption of dopamine transport by DDT and its metabolites. Neurotoxicology (2008) 682-690
16. Hatcher J.M., Richardson J.R., Guillot T.S., McCormack A.L., Di Monte D.A., Jones D.P., et al. Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system. Exp Neurol 204 2 (2007) 619-630
17. Hensley K., Pye Q.N., Maidt M.L., Stewart C.A., Robinson K.A., Jeffrey F., et al. Interaction of alpha-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site. J Neurochem 71 6 (1998) 2549-2557
18. Kamel F., and Hoppin J.A. Association of pesticide exposure with neurologic dysfunction and disease. Environ Health Perspect 112 9 (2004) 950-958
19. Kamel F., Tanner C.M., Umbach D.M., Hoppin J.A., Alavanja M.C., Blair A., et al. Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am J Epidemiol 165 4 (2007) 364-374
20. Kanthasamy A.G., Kitazawa M., Kanthasamy A., and Anantharam V. Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology 26 (2005) 701-719
21. Langston J.W., Ballard P., Tetrud J.W., and Irwin I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219 4587 (1983) 979-980
22. Lee C.S., Han E.S., Jang Y.Y., Han J.H., Ha H.W., and Kim D.E. Protective effect of harmalol and harmaline on MPTP neurotoxicity in the mouse and dopamine-induced damage of brain mitochondria and PC12 cells. J Neurochem 75 2 (2000) 521-531
23. Lee D.W., and Opanashuk L.A. Polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress plays a role in dopaminergic cell injury. Neurotoxicology 25 6 (2004) 925-939
24. Lin M.T., and Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443 7113 (2006) 787-795
25. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 1 (1951) 265-275
26. Lyng G.D., and Seegal R.F. Polychlorinated biphenyl-induced oxidative stress in organotypic co-cultures: experimental dopamine depletion prevents reduction in GABA. Neurotoxicology 29 2 (2008) 301-308
27. Maragos W.F., Zhu J., Chesnut M.D., and Dwoskin L.P. Mitochondrial toxin inhibition of [(3)H]dopamine uptake into rat striatal synaptosomes. Biochem Pharmacol 63 8 (2002) 1499-1505
28. Nicklas W.J., Vyas I., and Heikkila R.E. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci 36 26 (1985) 2503-2508
29. Park S.U., Ferrer J.V., Javitch J.A., and Kuhn D.M. Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons. J Neurosci 22 11 (2002) 4399-4405
30. Pennell, KD, Hatcher, JM, Caudle, WM, Richardson, JR, Gearing, M, Levey, AI, et al. Elevated levels of dieldrin are associated with Parkinson's disease. In: Preprints for Extended Abstracts, 46(2): special Symposium on Persistent, Bioaccumulative and Toxic Chemicals, Division of Environmental Chemistry. American Chemical Society 232nd National Meeting, San Francisco, CA; 2006.
31. Priyardarshi A, Khuder SA, Schaub EA, Shrivastava S. A meta-analysis of Parkinson's disease and exposure to pesticides. Neurotoxicology 2000;(4):435-40.
32. Richardson J.R., and Miller G.W. Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels. Toxicol Lett 148 1-2 (2004) 29-40
33. Richardson J.R., Caudle W.M., Wang M., Dean E.D., Pennell K.D., and Miller G.W. Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease. FASEB J 20 10 (2006) 1695-1697
34. Richardson J.R., Caudle W.M., Guillot T.S., Watson J.L., Nakamaru-Ogiso E., Seo B.B., et al. Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Toxicol Sci 95 1 (2007) 196-204
35. Richardson J.R., Caudle W.M., Wang M., Dean E.D., Pennell K.D., and Miller G.W. Developmental heptachlor exposure increases susceptibility of dopamine neurons to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in a gender-specific manner. Neurotoxicology 29 (2008) 855-863
36. Schuh RA, Kristián T, Gupta RK, Flaws JA, Fiskum G. Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol Sci 2005;(2):495-504.
37. Sherer T.B., Betarbet R., Stout A.K., Lund S., Baptista M., Panov A.V., et al. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci 22 16 (2002) 7006-7015
38. Sherer T.B., Betarbet R., Testa C.R., Seo B.B., Richardson J.R., Kim J.H., et al. Mechanism of toxicity in rotenone models of Parkinson's disease. J Neurosci 23 34 (2003) 10756-10764
39. Sims N.R. Rapid isolation of metabolically active mitochondria from rat brain and subregions using percoll density gradient centrifugation. J Neurochem 55 (1990) 698-707
40. Smith AG. DDT and its analogs. In: Krieger RI, editor. Handbook of pesticide toxicology. San Diego: Academic Press; 2001;1305-55.
41. Testa C.M., Sherer T.B., and Greenamyre J.T. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Brain Res Mol Brain Res 134 1 (2005) 109-118
42. Wang Y.M., Gainetdinov R.R., Fumagalli F., Xu F., Jones S.R., Bock C.B., et al. Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron 19 6 (1997) 1285-1296
43. Warner T.T., and Schapira A.H. Genetic and environmental factors in the cause of Parkinson's disease. Ann Neurol 53 3 (2003) S16-S25
44. Watabe, M, Nakaki, T. Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells. Mol Pharmacol 2008; Jul 3 [Epub ahead of print].