Mitochondrial toxin inhibition of [3H]dopamine uptake into rat striatal synaptosomes

Biochemical Pharmacology

Volumn 63, Issue 8, 2002, Pages 1499-1505

  Maragos, William F ^a,b   Zhu, Jun ^b   Chesnut, M Dathan ^b   Dwoskin, Linda P ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

3 Nitropropionic acid; Dopamine transporter; Huntington's disease; Malonate; Rotenone; Striatum

Indexed keywords

3 NITROPROPIONIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AZIDE; CYANIDE; CYTOCHROME C OXIDASE; DOPAMINE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; FREE RADICAL; MALONIC ACID; N TERT BUTYL ALPHA PHENYLNITRONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; ROTENONE; SUCCINATE DEHYDROGENASE; TOXIN; TRITIUM;

ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; BRAIN SYNAPTOSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE UPTAKE; ENZYME INHIBITION; EXTRACELLULAR SPACE; INHIBITION KINETICS; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; SPIN TRAPPING; TOXICITY;

ANIMALS; BIOLOGICAL TRANSPORT; CORPUS STRIATUM; DOPAMINE; MALE; MALONATES; MITOCHONDRIA; NITRO COMPOUNDS; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTOSOMES; TRITIUM;

EID: 0037090963     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)00910-3     Document Type: Article

References (32)

1. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
2. Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid
3. Alternative excitotoxic hypotheses
4. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
5. Excitotoxicity, free radicals, and cell membrane changes
6. 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions
7. Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease
8. Toxicity of dopamine to striatal neurons in vitro and potentiation of cell death by a mitochondrial inhibitor
9. Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum
10. Malonate-induced generation of reactive oxygen species in rat striatum depends on dopamine release but not on NMDA receptor activation
11. Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures
12. Dopamine transporters and neuronal injury
13. Hypothesis: The role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease
14. 3H]dopamine uptake in the nucleus accumbens, striatum and frontal cortex of rats
15. In vivo spin trapping of xenobiotic free radical metabolites
16. 50) of an enzymatic reaction
17. Relationships between ATP depletion, membrane potential, and the release of neurotransmitters in rat nerve terminals. An in vitro study under conditions that mimic anoxia, hypoglycemia, and ischemia
18. Modification of dopamine transporter function: Effect of reactive oxygen species and dopamine
19. The cellular production of hydrogen peroxide
20. Do mitochondria produce oxygen radicals in vivo?
21. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate
22. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
23. Parkinson disease: A new link between monoamine oxidase and mitochondrial electron flow
24. Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro
25. The high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopaminergic neurons from the substantia nigra
26. Striatal dopamine release in vivo following neurotoxic doses of methamphetamine and effect of the neuroprotective drugs, chlormethiazole and dizocilpine
27. The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum
28. Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels
29. Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine
30. Rapid and reversible effects of methamphetamine on dopamine transporters
31. Oxygen radicals diminish dopamine transporter function in rat striatum