Ring opening of aziridines with ortho-bromophenyl metal reagents: synthesis of 2-substituted indolines

Tetrahedron Letters

Volumn 50, Issue 17, 2009, Pages 1920-1923

  Michaelis, David J ^a   Dineen, Thomas A ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZIRIDINE DERIVATIVE; HALOGEN; INDOLE DERIVATIVE; LITHIUM; PHENETHYLAMINE DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CYCLIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RING OPENING; SYNTHESIS; TEMPERATURE MEASUREMENT;

EID: 61749099483     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.02.047     Document Type: Article

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46. 6, 23 °C) δ ppm 7.58 (d, J = 7.9 Hz, 2H), 7.15-7.28 (m, 6H), 7.04 (t, J = 8.1 Hz, 1H), 6.67 (d, J = 9.5 Hz, 1H), 4.06-4.16 (m, 1H), 3.15 (dd, J = 13.4, 9.5 Hz, 1H), 3.03 (dd, J = 13.4, 4.6 Hz, 1H), 2.91 (dd, J = 13.7, 9.5 Hz, 1H), 2.72 (dd, J = 13.6, 5.3 Hz, 1H), 1.17 (s, 9H).