Bis-epoxyethyl derivatives of distamycin A modified on the amidino moiety: Induction of production of fetal hemoglobin in human erythroid precursor cells

International Journal of Molecular Medicine

Volumn 23, Issue 1, 2009, Pages 105-111

  Bianchi, Nicoletta ^a   Borgatti, Monica ^a   Fibach, Eitan ^b   Prus, Eugenia ^b   Zuccato, Cristina ^a   Breveglieri, Giulia ^a   Baraldi, Pier Giovanni ^a   Romagnoli, Romeo ^a   Gambari, Roberto ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

thalassemia; globin; Distamycin analog; Erythyroid differentiation; Fetal hemoglobin

Indexed keywords

BUTYRIC ACID; CISPLATIN; CYTARABINE; DISTAMYCIN A; DISTAMYCIN A DERIVATIVE; HEMOGLOBIN; HEMOGLOBIN F; HYDROXYUREA; MITHRAMYCIN; N [5 [[[5 [[[[3 AMINO 3 (CARBAMOYL)ETHYL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL] 4 BIS(OXIRANYL)AMINO 1 METHYL 1H PYRROLE 2 CARBOXAMIDE; N [5 [[[5 [[[[3 AMINO 3 (CYANOIMINO)PROPYL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL] 4 BIS(OXIRANYL)AMINO 1 METHYL 1H PYRROLE 2 CARBOXAMIDE; N [5 [[[5 [[[[3 AMINO 3 (HYDROXYIMINO)PROPYL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL] 4 BIS(OXIRANYL)AMINO 1 METHYL 1H PYRROLE 2 CARBOXAMIDE; N [5 [[[5 [[[[3 AMINO 3 (N METHYLCARBAMOYL)ETHYL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL]AMINO]CARBONYL] 1 METHYL 1H PYRROL 3 YL] 4 BIS(OXIRANYL)AMINO 1 METHYL 1H PYRROLE 2 CARBOXAMIDE; TALLIMUSTINE; UNCLASSIFIED DRUG; GAMMA GLOBIN; HEMATOLOGIC AGENT; MESSENGER RNA;

ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL STRAIN K 562; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; ERYTHROID PRECURSOR CELL; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; BETA THALASSEMIA; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

BETA-THALASSEMIA; CELL DIFFERENTIATION; CELL LINE, TUMOR; DISTAMYCINS; ERYTHROID PRECURSOR CELLS; FETAL HEMOGLOBIN; GAMMA-GLOBINS; HEMATOLOGIC AGENTS; HUMANS; K562 CELLS; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61749090935     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000107     Document Type: Article

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