Neuromedin U enhances proliferation of ACTH-stimulated adrenocortical cells in the rat

International Journal of Molecular Medicine

Volumn 23, Issue 1, 2009, Pages 99-104

  Trejter, Marcin ^a   Guidolin, Diego ^b   Nowak, Magdalena ^a   Macchi, Veronica ^b   Majchrzak, Mariola ^a   de Caro, Raffaele ^b   Malendowicz, Ludwik K ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Adrenal growth; Adrenocorticotropic hormone; Aldosterone; Corticosterone; Neuromedin U; Proliferative activity

Indexed keywords

ALDOSTERONE; CORTICOSTERONE; CORTICOTROPIN; NEUROMEDIN U 8; NEUROMEDIN U RECEPTOR 1; NEUROPEPTIDE RECEPTOR; UNCLASSIFIED DRUG; NEUROMEDIN U RECEPTOR; NEUROPEPTIDE; NEUROTRANSMITTER RECEPTOR;

ADRENAL CORTEX; ADRENAL CORTEX CELL; ADRENAL GLAND; ALDOSTERONE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; FEMALE; METAPHASE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZONA FASCICULATA; ZONA GLOMERULOSA; ANIMAL; BLOOD; CYTOLOGY; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING;

ADRENAL CORTEX; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CELL PROLIFERATION; NEUROPEPTIDES; RATS; RECEPTORS, NEUROTRANSMITTER; ZONA FASCICULATA; ZONA GLOMERULOSA;

EID: 61749084382     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000106     Document Type: Article

References (74)

1. Brighton PJ, Szekeres PG and Willars GB: Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 56: 231-248, 2004.
2. Malendowicz LK: Involvement of neuropeptides in the regulation of growth, structure and function of the adrenal cortex. Histol Histopath 8: 173-186, 1993.
3. Malendowicz LK: Role of neuromedins in the regulation of adrenocortical function. Horm Metab Res 30: 374-384, 1998.
4. Malendowicz LK, Nussdorfer GG, Nowak KW and Mazzocchi G: Effects of neuromedin U-8 on the rat pituitary-adrenocortical axis. In Vivo 7: 419-422, 1993.
5. Malendowicz LK and Nussdorfer GG: Neuromedin U (NMU)-23, but not NMU-8, inhibits basal corticosterone secretion by isolated zona fasciculata-reticularis cells of the rat adrenal cortex. Biomed Res 48: 291-294, 1993.
6. Malendowicz LK, Andreis PG, Markowska A, Nowak M, Warchol JB, Neri G and Nussdorfer GG: Effects of neuromedin U-8 on the secretory activity of the rat adrenal-cortex: evidence for an indirect action requiring the presence of the zona medullaris. Res Exp Med 194: 69-79, 1994.
7. Malendowicz LK, Nussdorfer GG, Markowska A, Tortorella C, Nowak M and Warchol JB: Effects of neuromedin-U (NmU)-8 on the rat hypothalamo-pituitary-adrenal axis: evidence of a direct effect of NmU-8 on the adrenal-gland. Neuropeptides 26: 47-53, 1994.
8. Malendowicz LK and Markowska A: Neuromedins and their involvement in the regulation of growth, structure and function of the adrenal cortex. Histol Histopathol 9: 591-601, 1994.
9. Niimi M, Murao K and Taminato T: Central administration of neuromedin U activates neurons in ventrobasal hypothalamus and brainstem. Endocrine 16: 201-206, 2001.
10. Ivanov TR, Lawrence CB, Stanley PJ and Luckman SM: Evaluation of neuromedin U actions in energy homeostasis and pituitary function. Endocrinology 143: 3813-3821, 2002.
11. Ozaki Y, Onaka T, Nakazato M, Saito J, Kanemoto K, Matsumoto T and Ueta Y: Centrally administered neuromedin U activates neurosecretion and induction of C-Fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat. Endocrinology 143: 4320-4329, 2002.
12. Wren AM, Small CJ, Abbott CR, Jethwa PH, Kennedy AR, Murphy KG, Stanley SA, Zollner AN, Ghatei MA and Bloom SR: Hypothalamic actions of neuromedin U. Endocrinology 143: 4227-4234, 2002.
13. Yokota M, Ozaki Y, Sakamoto F, Yamada S, Saito J, Fujihara H and Ueta Y: Fos expression in CRF-containing neurons in the rat paraventricular nucleus after central administration of neuromedin U. Stress 7: 109-112, 2004.
14. Thompson EL, Murphy KG, Todd JF, Martin NM, Small CJ, Ghatei MA, and Bloom SR: Chronic administration of NMU into the paraventricular nucleus stimulates the HPA axis but does not influence food intake or body weight. Biochem Biophys Res Commun 323: 65-71, 2004.
15. Ueta Y, Ozaki Y and Saito J: Novel G-protein coupled receptor ligands and neurohypophysial hormones. J Neuroendocrinol 16: 378-382, 2004.
16. Dallman MF: Control of adrenocortical growth in vivo. Endocr Res 10: 213-242, 1984-1985.
17. Taki TM and Nickerson PA: Differentiation and proliferation of adrenocortical cells during the early stages of regeneration. Lab Invest 53: 91-100, 1985.
18. Ulrich-Lay YM and Engeland WC: Hyperinnervation during adrenal regeneration influences the rate of functional recovery. Neuroendocrinology 71: 107-123, 2000.
19. Markowska A, Neri G, Hochol A, Nowak M, Nussdorfer GG and Malendowicz LK: Effects of leptin and leptin fragments on steroid secretion and proliferative activity of regenerating rat adrenal cortex. Int J Mol Med 13: 139-141, 2004.
20. Malendowicz LK, Rebuffat P, Tortorella C, Nussdorfer GG, Ziolkowska A and Hochol A: Effects of met-enkephalin on cell proliferation in different models of adrenocortical-cell growth. Int J Mol Med 15: 841-845, 2005.
21. Trejter M, Carraro G, Rucinski M, Hochol A, Rebuffat P, Nussdorfer GG and Malendowicz LK: Arginin-vasopressin regulates proliferative activity of the regenerating rat adrenal cortex. Int J Mol Med 15: 993-997, 2005.
22. Engeland WC and Dallman MF: Neural mediation of compensatory adrenal growth. Endocrinology 99: 1659-1662, 1976.
23. Dallman MF, Engeland WC and Shinsako J: Compensatory adrenal growth: a neurally mediated reflex. Am J Physiol 231: 408-414, 1976.
24. Dallman MF, Engeland WC and McBride MH: The neural regulation of compensatory adrenal growth. Ann NY Acad Sci 297: 373-392, 1977.
25. Dallman MF, Engeland WC, Holzwarth MA and Scholz PM: Adrenocorticotropin inhibits compensatory adrenal growth after unilateral adrenalectomy. Endocrinology 107: 1397-1404, 1980.
26. Townsend SF, Dallman MF and Miller WL: Rat insulin-like growth factor-I and -II mRNAs are unchanged during compensatory adrenal growth but decrease during ACTH-induced adrenal growth. J Biol Chem 265: 22117-22122, 1990.
27. Trejter M, Neri G, Rucinski M, Majchrzak M, Nussdorfer GG and Malendowicz LK: Neuromedin U stimulates enucleation-induced adrenocortical proliferation in the rat. Int J Mol Med 21: 683-687, 2008.
28. Ziolkowska A, Macchi C, Trejter MN, Rucinski M, Nowak M, Nussdorfer GG and Malendowicz LK: Neuromedin U effects on rat adrenocortical cells: in vitro and in vivo studies. Int J Mol Med 21: 303-307, 2008.
29. Malendowicz LK, Guidolin D, Trejter M, Porzionato A, Rucinski M, De Caro R and Nowak M: Neuromedin U inhibits unilateral-adrenalectomy induced compensatory adrenal growth in the rat. Peptides (In press).
30. Michat L and Nouet IC: Variations nycthemerales de l'activite mitotique dans la corticosurrenale du rat male. CR Soc Biol 169: 1421-1424, 1975.
31. Stachowiak A, Nussdorfer GG and Malendowicz LK: Proliferation and distribution of adrenocortical cells in the gland of ACTH- or dexamethasone-treated rats. Histol Histopathol 5: 25-29, 1990.
32. Malendowicz LK, Neri G, Jedrzejczak N, Hochol A and Nussdorfer GG: Effects of recombinant murine leptin [1-147] and leptin fragment 116-130 on steroid secretion and proliferative activity of the regenerating rat adrenal cortex. Endocr Res 26: 109-118, 2000.
33. Hochol A, Albertin G, Nussdorfer GG, Spinazzi R, Ziolkowska A, Rucinski M and Malendowicz LK: Effects of neuropeptides B and W on the secretion and growth of rat adrenocortical cells. Int J Mol Med 14: 843-847, 2004.
34. Rucinski M, Spinazzi R, Ziolkowska A, Nussdorfer GG and Malendowicz LK: Effects of beacon on the rat pituitary-adrenocortical axis response to stress. Int J Mol Med 16: 297-299, 2005.
35. Hosoya M, Moriya T, Kawamata Y, Ohkubo S, Fujii R, Matsui H, Shintani Y, Fukusumi S, Habata Y, Hinuma S, Onda H, Nishimura O and Fujino M: Identification and functional characterization of a novel subtype of neuromedin U receptor. J Biol Chem 275: 29528-29532, 2000.
36. Raddatz R, Wilson AE, Artymyshyn R, Bonini JA, Borowsky B, Boteju LW, Zhou S, Kouranova EV, Nagorny R, Guevarra MS, Dai M, Lerman GS, Vaysse PJ, Branchek TA, Gerald C, Forray C and Adham N: Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J Biol Chem 275: 32452-32459, 2000.
37. Shan LX, Qiao XD, Crona JH, Behan J, Wang S, Laz T, Bayne M, Gustafson EL, Monsma FJ and Hedrick JA: Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. J Biol Chem 275: 39482-39486, 2000.
38. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH and Liu Q: Identification of receptors for neuromedin U and its role in feeding. Nature 406: 70-74, 2000.
39. Hedrick JA, Morse K, Shan L, Qiao X, Pang L, Wang S, Laz T, Gustafson EL, Bayne M and Monsma JF: Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol Pharmacol 58: 870-875, 2000.
40. Westfall TD, McCafferty GP, Pullen M, Gruver S, Sulpizio AC, Aiyar VN, Disa J, Contino LC, Mannan IJ and Hieble JP: Characterisation of neuromedin U effects in canine smooth-muscle. J Pharmacol Exp Ther 301: 987-992, 2001.
41. Szekeres PG, Muir AI, Spinage LD, Miller JE, Butler SI, Smith A, Rennie GI, Murdock PR, Fitzgerald LR, Wu H, McMillan LJ, Guerrera S, Vawter L, Elshourbagy NA, Mooney JL, Bergsma DJ, Wilson S and Chambers JK: Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. J Biol Chem 275: 20247-20250, 2000.
42. Fujii R, Hosoya M, Fukusami S, Kazamata Y, Habata Y, Hinuma S, Onda H, Nishimura O and Fujino M: Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. J Biol Chem 275: 21068-21074, 2000.
43. Graham ES, Turnbull Y, Fotheringham P, Nilaweera K, Mercer JG, Morgan PJ and Barrett P: Neuromedin U and neuromedin U receptor-2 expression in the mouse and rat hypothalamus: effects of nutritional status. J Neurochem 87: 1165-1173, 2003.
44. Qiu DL, Chu CP, Shirasaka T, Nabekura T, Kunitake T, Kato K, Nakazato M, Katoh T and Kannan H: Neuromedin U depolarizes rat hypothalamic paraventricular nucleus neurons in vitro by enhancing IH channel activity. J Neurophysiol 90: 843-850, 2003.
45. Qiu DL, Chu CP, Tsukino H, Shirasaka T, Nakao H, Kato K, Kunitake T, Katoh T and Kannan H: Neuromedin U receptor-2 mRNA and HCN channels mRNA expression in NMU-sensitive neurons in rat hypothalamic paraventricular nucleus. Neurosci Lett 374: 69-72, 2005.
46. Ida T, Mori K, Miyazato M, Egi Y, Abe S, Nakahara K, Nishihara M, Kangawa K and Murakami N: Neuromedin S is a novel anorexigenic hormone. Endocrinology 146: 4217-4223, 2005.
47. Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M and Kangawa K: Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J 26: 325-335, 2005.
48. Rucinski M, Ziolkowska A, Neri G, Trejter M, Zemleduch T, Tyczewska M, Nussdorfer GG and Malendowicz LK: Neuromedin S, neuromedin U and their receptors in the hypothalamus and endocrine glands of the rat. Int J Mol Med 20: 255-259, 2007.
49. Farese RV and Reddy WJ: Observations on the interrelations between adrenal protein, RNA and DNA during prolonged ACTH administration. Biochem Biophys Acta 76: 145-148, 1963.
50. Imrie RC, Ramaiah TR, Antoni F and Hutchison WC: The effect of adrenocorticotropin on the nucleic acid metabolism of the rat adrenal gland. J Endocrinol 32: 303-312, 1965.
51. Belloni AS, Mazzocchi G, Meneghelli V and Nussdorfer GG: Cytogenesis in the rat adrenal cortex: evidence for an ACTH-induced centripetal cell migration from the zona glomerulosa. Arch Anat Histol Embryol 61: 195-205, 1978.
52. Payet N, Lehoux JG and Isler H: Effect of ACTH on the proliferative and secretory activities of the adrenal glomerulosa. Acta Endocrinol 93: 365-374, 1980.
53. Malendowicz LK: A correlated stereological and functional studies on the long-term effects of ACTH on rat adrenal cortex. Folia Histochem Cytobiol 24: 203-211, 1986.
54. Mazzocchi G, Malendowicz LK, Rebuffat P, Robba C, Gottardo G and Nussdorfer GG: Short- and long-term effects of ACTH on the adrenal zona glomerulosa of the rat. A coupled stereological and enzymological study. Cell Tissue Res 243: 303-310, 1986.
55. Miskowiak B, Kasprzak A and Malendowicz LK: Comparative stereological studies on the effects of long term CRF and ACTH treatment on the cortex of the suprarenal gland. J Anat 146: 167-172, 1986.
56. Nussdorfer GG: Cytophysiology of the adrenal cortex. Int Rev Cytol 98: 1-405,1986.
57. Malendowicz LK, Nussdorfer GG, Markowska A and Nowak KW: Analysis of the preventive action of ACTH on dexamethasone-induced adrenocortical atrophy in the rat. Cytobios 71: 191-199, 1992.
58. Ramachandran J and Suyama AT: Inhibition of replication of normal adrenocortical cells in culture by adrenocorticotropin. Proc Natl Acad Sci USA 72: 113-117, 1975.
59. Rybak SM and Ramachandran J: Primary culture of normal rat adrenocortical cells. I. Culture conditions for optimal growth and function. In Vitro 17: 599-604, 1981.
60. Ziolkowska A, Belloni AS, Nussdorfer GG, Nowak M and Malendowicz LK: Endocrine disruptors and rat adrenocortical function: studies on freshly dispersed and cultured cells. Int J Mol Med 18: 1165-1168, 2006.
61. Hinson JP, Vinson GP, Whitehouse BJ and Price GM: Effects of stimulation on steroid output and perfusion medium flow rate in the isolated perfused rat adrenal gland in situ. J Endocrinol 109: 279-285, 1986.
62. Hinson JP, Vinson GP, Kapas S and Teja R: The relationship between adrenal vascular events and steroid secretion: the role of mast cells and endothelin. J Steroid Biochem Mol Biol 40: 381-389, 1991.
63. Thomas M, Keramidas M, Monchaux E and Feige JJ: Role of adrenocorticotropic hormone in the development and maintenance of the adrenal cortical vasculature. Microsc Res Tech 61: 247-251, 2003.
64. Thomas M, Keramidas M, Monchaux E and Feige JJ: Dual hormonal regulation of endocrine tissue mass and vasculature by adrenocorticotropin in the adrenal cortex. Endocrinology 145: 4320-4329, 2004.
65. Minamino N, Kangawa K and Matsuo H: Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem Biophys Res Commun 130: 1078-1085, 1985.
66. Chu C, Jin Q, Kunitake T, Kato K, Nabekura T, Nakazato M, Kangawa K and Kannan H: Cardiovascular actions of central neuromedin U in conscious rats. Regul Pept 105: 29-34, 2002.
67. Jones NA, Morton MF, Prendergast CE, Powell GL, Shankley NP and Hollingsworth SJ: Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro. Regul Pept 136: 109-116, 2006.
68. Bertholet JY: Proliferative activity and cell migration in the adrenal cortex of fetal and neonatal rats: an autoradiographic study. J Endocrinol 87: 1-9, 1980.
69. Malendowicz LK and Jachimowicz B: Sex differences in adrenocortical structure and function. XI. Autoradiographic studies on cell proliferation and turnover in the adrenal cortex of the male and female rat and its dependence on testosterone and estradiol. Cell Tissue Res 227: 651-657, 1982.
70. Zajicek G, Ariel I and Arber N: The streaming adrenal cortex: direct evidence of centripetal migration of adrenocytes by estimation of cell turnover rate. J Endocrinol 111: 477-482, 1986.
71. McNicol AM and Duffy AE: A study of cell migration in the adrenal cortex of the rat using bromodeoxyuridine. Cell Tissue Kinet 20: 519-526, 1987.
72. Morley SD, Viard I, Chung BC, Ikeda Y, Parker KL and Mullins JJ: Variegated expression of a mouse steroid 21-hydroxylase/ beta-galactosidase transgene suggests centripetal migration of adrenocortical cells. Mol Endocrinol 10: 585-598, 1996.
73. Mitani F, Mukai K, Miyamoto H, Suematsu M and Ishimura Y: Development of functional zonation in the rat adrenal cortex. Endocrinology 140: 3342-3353, 1999.
74. Rebuffat P, Macchi C, Malendowicz LK and Nussdorfer GG: Up-regulation of adrenomedullin receptor gene expression in activated local stem cells during rat adrenal regeneration. Int J Mol Med 20: 855-858, 2007.