Up-regulation of adrenomedullin receptor gene expression in activated local stem cells during rat adrenal regeneration

International Journal of Molecular Medicine

Volumn 20, Issue 6, 2007, Pages 855-858

  Rebuffat, Piera ^a   Macchi, Carlo ^a   Malendowicz, Ludwik K ^b   Nussdorfer, Gastone G ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Adrenal regeneration; Adrenomedullin; Adrenomedullin receptors; Gene expression; Rat

Indexed keywords

ADRENOMEDULLIN RECEPTOR, RAT; G PROTEIN COUPLED RECEPTOR; ISOPROTEIN; UNCLASSIFIED DRUG;

ADRENAL GLAND; ADRENALECTOMY; ANIMAL; ARTICLE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PHYSIOLOGY; RAT; REGENERATION; SPRAGUE DAWLEY RAT; STEM CELL; UPREGULATION;

ADRENAL GLANDS; ADRENALECTOMY; ANIMALS; GENE EXPRESSION REGULATION; MALE; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; REGENERATION; STEM CELLS; UP-REGULATION;

EID: 42149177878     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.20.6.855     Document Type: Article

References (33)

1. Nussdorfer GG: Cytophysiology of the adrenal cortex. Int Rev Cytol 98: 1-405 1986.
2. Mitani F, Mukai K, Miyamoto H, Suematsu M and Ishimura Y: The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex. Biochim Biophys Acta 1619: 317-324, 2003.
3. Dallman MF: Control of adrenocortical growth in vivo. Endocr Res 10: 213-242, 1984.
4. Taki TM and Nickerson PA: Differentiation and proliferation of adrenocortical cells during early stages of regeneration. Lab Invest 53: 91-100, 1985.
5. Engeland WC and Levay-Young BK: Changes in the glomerulosa cell phenotype during adrenal regeneration in rats. Am J Physiol 276: R1374-R1382, 1999.
6. Albertin G, Rucinski M, Carraro G, Forneris M, Andreis PG, Malendowicz LK and Nussdorfer GG: Adrenomedullin and vascular endothelium growth factor genes are overexpressed in the regenerating rat adrenal cortex, and AM and VEGF reciprocally enhance their mRNA expression in cultured rat adrenocortical cells. Int J Mol Med 16: 431-435, 2005.
7. Rebuffat P, Macchi C, Malendowicz LK and Nussdorfer GG: Up-regulation of adrenomedullin gene expression in the regenerating rat adrenal cortex. Int J Mol Med 20: 551-555, 2007.
8. Lopez J and Martinez A: Cell and molecular biology of the multifunctional peptide adrenomedullin. Int Rev Cytol 221: 1-92, 2002. (Pubitemid 35429860)
9. Poyner DR, Sexton PM, Marshal I, Smith DM, Quirion R, Born W, Muff R, Fisher JA and Foord SM: International union of pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin and calcitonin receptors. Pharmacol Rev 54: 233-246, 2002.
10. Nussdorfer GG: Proadrenomedullin-derived peptides in the paracrine control of the hypothalamo-pituitary-adrenal axis. Int Rev Cytol 206: 249-284, 2001.
11. Andreis PG, Albertin G, Conconi MT, Carraro G, Malendowicz LK, Ziolkowska A and Nussdorfer GG: Evidence for an autocrine-paracrine role of adrenomedullin in the cultured rat adrenal zona glomerulosa cells. Int J Mol Med 10: 401-405, 2002.
12. Rebuffat P, Forneris ML, Aragona F, Ziolkowska A, Malendowicz LK and Nussdorfer GG: Adrenomedullin and its receptors are expressed in the zona glomerulosa of human adrenal gland: Evidence that ADM enhances proliferation and decreases apoptosis in cultured ZG cells. Int J Mol Med 9: 119-124, 2002.
13. Malendowicz LK, Conconi MT, Parnigotto PP and Nussdorfer GG: Endogenous adrenomedullin system regulates the growth of rat adrenocortical cells cultured in vitro. Regul Pept 112: 27-31, 2003.
14. Albertin G, Carraro G and Nussdorfer GG: Human adrenomedullin gene silencing by short interfering RNAs: A preliminary study. Int J Mol Med 15: 579-583, 2005.
15. Andreis PG, Rucinski M, Neri G, Conconi MT, Petrelli L, Parnigotto PP, Malendowicz LK and Nussdorfer GG: Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCl-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects. Int J Mol Med 16: 1021-1028, 2005.
16. Rucinski M, Andreis PG, Ziolkowska A, Nussdorfer GG and Malendowicz LK: Differential expression and function of beacon in the rat adrenal cortex and medulla. Int J Mol Med 16: 35-40, 2005.
17. Albertin G, Carraro G, Petrelli L, Guidolin D, Neri G and Nussdorfer GG: Endothelin-1 and adrenomedullin enhance the growth of human adrenocortical carcinoma-derived SW-13 cell line by stimulating proliferation and inhibiting apoptosis. Int J Mol Med 15: 469-474, 2005.
18. Rucinski M, Albertin G, Spinazzi R, Ziolkowska A, Nussdorfer GG and Malendowicz LK: Cerebellin in the rat adrenal gland: Gene expression and effects of CER and [des-Ser1]CER on the secretion and growth of cultured adrenocortical cells. Int J Mol Med 15: 411-415, 2005.
19. Rossi GP, Sticchi D, Giuliani L, Bernante P, Zavattero S, Pessina AC and Nussdorfer GG: Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas. Int J Mol Med 17: 975-980, 2006.
20. Carraro G, Albertin G, Aragona F, Forneris M, Casale V, Spinazzi R and Nussdorfer GG: Age-dependent decrease in the ghrelin gene expression in the human adrenal cortex: A real time PCR study. Int J Mol Med 17: 319-321, 2006.
21. Rucinski M, Ziolkowska A, Hochól A, Pucher A, Macchi C, Belloni AS, Nussdorfer GG and Malendowicz LK: Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1a gene expression in primary culture of rat calvarial osteoblast-like cells. Int J Mol Med 18: 565-570, 2006.
22. Ziolkowska A, Rucinski M, Tyczewska M, Belloni AS, Nowak M, Nussdorfer GG and Malendowicz LK: Down-regulation of the beacon gene expression in the regenerating rat adrenal cortex. Peptides 27: 3216-3219, 2006.
23. Ziolkowska A, Tortorella C, Nussdorfer GG, Rucinski M, Majchrzak M and Malendowicz LK: Accumulation of steroidogenic acute regulatory protein mRNA and decrease in the secretory and proliferative activity of rat adrenocortical cells in the presence of proteasome inhibitors. Int J Mol Med 17: 865-868, 2006.
24. 3 mRNA levels are increased in failing rat cardiomyocytes and associated with increased responsiveness to adrenomedullin. J Mol Cell Cardiol 38: 145-151, 2005.
25. Pan CS, Jiang W, Zhong GZ, Zhao J, Pang YZ, Tang CS and Qi YF: Hypertension induced nitric oxide synthase inhibitor increases responsiveness of ventricular myocardium and aorta of rat tissue to adrenomedullin stimulation in vitro. Life Sci 78: 398-405, 2005.
26. Bell D, Zhao YY, Kelso EJ, McHenry EM, Rush LM, Lamont VM, Nicholls DP and McDermott BJ: Up-regulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric oxide synthesis in rats. Am J Physiol 290: H904-H914, 2006.
27. Pan CS, Jiang W, Wu SY, Zhao J, Pang YZ, Tang CS and Qi YF: Potentiated response to adrenomedullin in myocardia and aortas in spontaneously hypertensive rat. Basic Res Cardiol 101: 193-203, 2006.
28. Schwarz N, Renshaw D, Kapas S and Hinson JP: Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells. J Endocrinol 190: 505-514, 2006.
29. Albertin G, Ruggero M, Guidolin D and Nussdorfer GG: Gene silencing of human RAMP2 mediated by short-interfering RNA. Int J Mol Med 18: 531-535, 2006.
30. Nagaya N, Mori H, Mukotami S, Kangawa K and Kitamura S: Adrenomedullin: angiogenesis and gene therapy. Am J Physiol 288: R1432-R1437, 2005.
31. Ribatti D, Nico B, Spinazzi R, Vacca A and Nussdorfer GG: The role of adrenomedullin in angiogenesis. Peptides 26: 1670-1675, 2005.
32. Nikitenko LL, Fox SB, Kekoe S, Rees MCP and Bicknell R: Adrenomedullin and tumor angiogenesis. Br J Cancer 94: 1-7, 2006.
33. Ribatti D, Conconi MT and Nussdorfer GG: Non-classical endogenous regulators of angiogenesis. Pharmacol Rev 59: 185-205, 2007.