Ancient ubiquitous protein 1 and Syk link cytoplasmic tails of the integrin αIIbβ3

Platelets

Volumn 20, Issue 2, 2009, Pages 105-110

  Kato, Atsushi ^a,b   Oshimi, Kazuo ^a  

^a JUNTENDO UNIVERSITY   (Japan)

^b MUSASHINO RED CROSS HOSPITAL   (Japan)

Author keywords

Ancient ubiquitous protein 1(Aup1); Cytoplasmic tails; Inside out signaling; Integrin IIb 3; Src; Syk

Indexed keywords

ANCIENT UBIQUITOUS PROTEIN 1; CELL PROTEIN; FIBRINOGEN; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN; INTEGRIN ALPHA2B BETA3; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; ENZYME ASSAY; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; ENZYME ACTIVATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 61649099080     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.1080/09537100802641507     Document Type: Article

References (28)

1. 3 for its pathogenesis. Crit Rev Oncol Hematol 1997;26:1-23.
2. 3. J Clin Invest 2005;115:3363-3369.
3. 3: Activation mechanisms. J Thromb Haemostas 2007;5:1345-1352.
4. Hughes PE, Gonzalez FD, Leong L, Wu C, McDonald JA, Shattil SJ, Ginsberg MH. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem 1996;271:6571-6574.
5. Takagi J, Petre BM, Walz T, Springer TA. Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell 2002;110:599-611.
6. 3 "inside-out" activation as regulated by its cytoplasmic face. Cell 2002;110:587-597.
7. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003;301:1720-1725.
8. 3 activation by distinct regions of its cytoplasmic tails. Biochemistry 2006;45:6656-6662.
9. 3 integrin transmembrane and cytoplasmic domains in its resting state. Structure 2005;13:703-712.
10. 3 and to calcium and integrin-binding protein. J Biol Chem 1999;274:17257-17266.
11. 3 activation. J Cell Biol 2006;172:169-175.
12. 3. J Biol Chem 2002;277:28937-28941.
13. 3- associated protein, functionally regulates platelet activation. J Biol Chem 2004;279:27286-27293.
14. 3 cytoplasmic tail. J Cell Biol 1997;137:1433-1443.
15. Calderwood DA, Zent R, Grant R, Rees DJG, Hynes RO, Ginsberg MH. The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation. J Biol Chem 1999;274:28071-28074.
16. Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell LD. Structural basis of integrin activation by talin. Cell 2007;128:171-182.
17. c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol Cell Biol 1993;3:1863-1871.
18. 2+ mobilization in platelets. J Biol Chem 1993;268:2277-2279.
19. 3. J Biol Chem 1994;269:28859-28864.
20. 3 initiate integrin signaling to the cytoskeleton. J Cell Biol 2002;157:265-275.
21. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin β cytoplasmic domain. Proc Natl Acad Sci USA 2003;100:13298-13302.
22. 3- associated syk in platelets. Biochem J 1999;338:677-680.
23. 3 signaling. Am J Physiol Cell Physiol 2006;291:C1346-C1354.
24. Woodside DG, Obergfell A, Leng L, Wilsbacher JL, Miranti CK, Brugge JS, Shattil SJ, Ginsberg MH. Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains. Curr Biol 2001;11:1799-1804.
25. Couture C, Williams S, Gauthier N, Tailor P, Mustelin T. Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate phosphorylation by Syk protein-tyrosine kinase. Eur J Biochem 1997;246:447-451.
26. El-Hillal O, Kurosaki T, Yamamura H, Kinet J-P, Scharenberg AM. Syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction. Proc Natl Acad Sci USA 1997;94:1919-1924.
27. Taniguchi T, Kobayashi T, Kondo J, Takahashi K, Nakamura H, Suzuki J, Nagai K, Yamada T, Nakamura S, Yamamura H. Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem 1991;266:15790-15796.
28. Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH. The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine -independent binding to integrin β cytoplasmic domains. J Biol Chem 2002;277:39401-39408.