Thermally triggered intracellular explosion of volume transition nanogels for necrotic cell death

Journal of Controlled Release

Volumn 135, Issue 1, 2009, Pages 89-95

  Lee, Yuhan ^a   Park, Sung Young ^a   Kim, Chunsoo ^a   Park, Tae Gwan ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Cell death; Membrane disruption; Stimuli sensitive hydrogels; Volume transition nanogels

Indexed keywords

CANCER CELLS; CELLULAR MEMBRANES; COLD SHOCKS; CYTOSKELETON; EXTERNAL STIMULUS; INTRACELLULAR VOLUMES; L LYSINES; L-LACTIC ACIDS; MEMBRANE DISRUPTION; MICRO-SCALE; NECROTIC CELL DEATHS; POLY(ETHYLENE GLYCOL); POLY(PROPYLENE OXIDE); POLYETHYLENEOXIDE; SELF-ASSEMBLED NETWORKS; STIMULI-SENSITIVE HYDROGELS; SUB-CELLULAR; TEMPERATURE CHANGES; VOLUME TRANSITION NANOGELS;

AMINO ACIDS; BODY FLUIDS; CELL DEATH; ETHYLENE; ETHYLENE GLYCOL; FLEXIBLE STRUCTURES; HYDROGELS; INSECTICIDES; LACTIC ACID; NANOSTRUCTURED MATERIALS; ORGANIC ACIDS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; PROPYLENE; THERMAL EFFECTS;

CELL MEMBRANES;

LACTIC ACID DERIVATIVE; MACROGOL; NANOBOMB; NANOGEL; NANOPARTICLE; POLOXAMER; POLYLYSINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL DAMAGE; CELL DEATH; CELL MEMBRANE; CELL VACUOLE; COLD EXPOSURE; CONTROLLED STUDY; CYTOSKELETON; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; GEL; HUMAN; HUMAN CELL; MEMBRANE STRUCTURE; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

APOPTOSIS; CELL SURVIVAL; DRUG CARRIERS; FLUORESCEIN-5-ISOTHIOCYANATE; HELA CELLS; HUMANS; HYDROGELS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NECROSIS; PARTICLE SIZE; PHASE TRANSITION; POLYESTERS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYLYSINE; SURFACE PROPERTIES; TEMPERATURE;

EID: 61649098786     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.12.008     Document Type: Article

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