메뉴 건너뛰기




Volumn 324, Issue 1-2, 2009, Pages 201-206

The phosphorylation status of merlin in sporadic vestibular Schwannomas

Author keywords

Cyclin dependent kinases; Merlin; Phosphorylated merlin; Ras; Schwannomas

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; MERLIN; P21 ACTIVATED KINASE; PROTEIN P27; RAC PROTEIN; RAS PROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 61549138113     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-0014-0     Document Type: Article
Times cited : (8)

References (32)
  • 1
    • 0030957310 scopus 로고    scopus 로고
    • The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2
    • doi: 10.1001/jama.278.1.51
    • Gutmann DH, Aylsworth A, Carey JC et al (1997) The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 278:51-57. doi: 10.1001/jama.278.1.51
    • (1997) JAMA , vol.278 , pp. 51-57
    • Gutmann, D.H.1    Aylsworth, A.2    Carey, J.C.3
  • 2
    • 0033981059 scopus 로고    scopus 로고
    • Population-based analysis of sporadic and NF2-associated meningiomas and schwannomas
    • Antinheimo J, Sankila R, Carpen O et al (2000) Population-based analysis of sporadic and NF2-associated meningiomas and schwannomas. Neurology 54:71-76
    • (2000) Neurology , vol.54 , pp. 71-76
    • Antinheimo, J.1    Sankila, R.2    Carpen, O.3
  • 3
    • 0029784764 scopus 로고    scopus 로고
    • Neurofibromatosis and associated tumor suppressor genes
    • Zwarthoff EC (1996) Neurofibromatosis and associated tumor suppressor genes. Pathol Res Pract 192:647-657
    • (1996) Pathol Res Pract , vol.192 , pp. 647-657
    • Zwarthoff, E.C.1
  • 4
    • 0032522603 scopus 로고    scopus 로고
    • Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
    • doi: 10.1101/gad.12.8.1121
    • McClatchey AI, Saotome I, Mercer K et al (1998) Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 12:1121-1133. doi: 10.1101/gad.12.8.1121
    • (1998) Genes Dev , vol.12 , pp. 1121-1133
    • McClatchey, A.I.1    Saotome, I.2    Mercer, K.3
  • 5
    • 0034234894 scopus 로고    scopus 로고
    • Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2
    • Giovannini M, Robanus-Maandag E, van der Valk M et al (2000) Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev 14:1617-1630
    • (2000) Genes Dev , vol.14 , pp. 1617-1630
    • Giovannini, M.1    Robanus-Maandag, E.2    van der Valk, M.3
  • 6
    • 0031890998 scopus 로고    scopus 로고
    • NHE-RF, a regulatory cofactor for Na+-H+ exchange, is a common interactor for merlin and ERM proteins
    • doi: 10.1074/jbc.273.3.1273
    • Murthy A, Gonzalez-Agosti C, Cordero E et al (1998) NHE-RF, a regulatory cofactor for Na+-H+ exchange, is a common interactor for merlin and ERM proteins. J Biol Chem 273:1273-1276. doi: 10.1074/jbc.273.3.1273
    • (1998) J Biol Chem , vol.273 , pp. 1273-1276
    • Murthy, A.1    Gonzalez-Agosti, C.2    Cordero, E.3
  • 7
    • 0030759923 scopus 로고    scopus 로고
    • Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton
    • Sainio M, Zhao F, Heiska L et al (1997) Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton. J Cell Sci 110:2249-2260
    • (1997) J Cell Sci , vol.110 , pp. 2249-2260
    • Sainio, M.1    Zhao, F.2    Heiska, L.3
  • 8
    • 0031055161 scopus 로고    scopus 로고
    • Expression of neurofibromatosis 2 protein in human brain tumors: An immunohistochemical study
    • doi: 10.1007/s004010050608
    • Hitotsumatsu T, Iwaki T, Kitamoto T et al (1997) Expression of neurofibromatosis 2 protein in human brain tumors: An immunohistochemical study. Acta Neuropathol 93:225-232. doi: 10.1007/ s004010050608
    • (1997) Acta Neuropathol , vol.93 , pp. 225-232
    • Hitotsumatsu, T.1    Iwaki, T.2    Kitamoto, T.3
  • 9
    • 1842366662 scopus 로고    scopus 로고
    • Immunohistochemical detection of schwannomin and neurofibromin in vestibular Schwannomas, ependymomas and meningiomas
    • doi: 10.1097/00005072-199704000-00007
    • Huynh DP, Mautner V, Baser ME et al (1997) Immunohistochemical detection of schwannomin and neurofibromin in vestibular Schwannomas, ependymomas and meningiomas. J Neuropathol Exp Neurol 56:382-390. doi: 10.1097/ 00005072-199704000-00007
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 382-390
    • Huynh, D.P.1    Mautner, V.2    Baser, M.E.3
  • 10
    • 0030782724 scopus 로고    scopus 로고
    • Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system
    • doi: 10.1097/00005072-199705000-00004
    • Stemmer-Rachamimov AO, Gonzalez-Agosti C, Xu L et al (1997) Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system. J Neuropathol Exp Neurol 56:735-742. doi: 10.1097/00005072-199705000-00004
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 735-742
    • Stemmer-Rachamimov, A.O.1    Gonzalez-Agosti, C.2    Xu, L.3
  • 11
    • 0029077821 scopus 로고
    • The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells
    • Lutchman M, Rouleau GA (1995) The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells. Cancer Res 55:2270-2274
    • (1995) Cancer Res , vol.55 , pp. 2270-2274
    • Lutchman, M.1    Rouleau, G.A.2
  • 12
    • 0028168361 scopus 로고
    • An anti-Ras function of neurofibromatosis type 2 gene product (NF2/ Merlin)
    • Tikoo A, Varga M, Ramesh V et al (1994) An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin). J Biol Chem 269:23387-23390
    • (1994) J Biol Chem , vol.269 , pp. 23387-23390
    • Tikoo, A.1    Varga, M.2    Ramesh, V.3
  • 13
    • 0035871299 scopus 로고    scopus 로고
    • The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
    • doi: 10.1101/gad.189601
    • Morrison H, Sherman LS, Legg J et al (2001) The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev 15:968-980. doi: 10.1101/gad.189601
    • (2001) Genes Dev , vol.15 , pp. 968-980
    • Morrison, H.1    Sherman, L.S.2    Legg, J.3
  • 14
    • 0036154164 scopus 로고    scopus 로고
    • Transduction of wild-type merlin into human Schwannoma cells decreases Schwannoma cell growth and induces apoptosis
    • doi: 10.1093/hmg/11.1.69
    • Schulze KM, Hanemann CO, Muller HW, Hanenberg H (2002) Transduction of wild-type merlin into human Schwannoma cells decreases Schwannoma cell growth and induces apoptosis. Hum Mol Genet 11:69-76. doi: 10.1093/hmg/ 11.1.69
    • (2002) Hum Mol Genet , vol.11 , pp. 69-76
    • Schulze, K.M.1    Hanemann, C.O.2    Muller, H.W.3    Hanenberg, H.4
  • 15
    • 0030775695 scopus 로고    scopus 로고
    • Interdomain binding mediates tumor growth suppression by the NF2 gene product
    • doi: 10.1038/sj.onc.1201418
    • Sherman L, Xu HM, Geist RT et al (1997) Interdomain binding mediates tumor growth suppression by the NF2 gene product. Oncogene 15:2505-2509. doi: 10.1038/sj.onc.1201418
    • (1997) Oncogene , vol.15 , pp. 2505-2509
    • Sherman, L.1    Xu, H.M.2    Geist, R.T.3
  • 16
    • 0030271335 scopus 로고    scopus 로고
    • A question of balance: The role of cyclin-kinase inhibitors in development and tumorigenesis
    • doi: 10.1016/0962-8924(96)10030-1
    • Elledge SJ, Winston J, Harper JW (1996) A question of balance: The role of cyclin-kinase inhibitors in development and tumorigenesis. Trends Cell Biol 6:388-392. doi: 10.1016/0962-8924(96)10030-1
    • (1996) Trends Cell Biol , vol.6 , pp. 388-392
    • Elledge, S.J.1    Winston, J.2    Harper, J.W.3
  • 17
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-b-induced cell cycle arrest
    • doi: 10.1038/371257a0
    • Hannon GJ, Beach D (1994) p15INK4B is a potential effector of TGF-b-induced cell cycle arrest. Nature 371:257-261. doi: 10.1038/ 371257a0
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 18
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclindependent kinases
    • doi: 10.1016/0092-8674(93)90499-G
    • Harper JW, Adami GR, Wei N et al (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclindependent kinases. Cell 75:805-816. doi: 10.1016/0092-8674(93)90499-G
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3
  • 19
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-b
    • doi: 10.1101/gad.9.15.1831
    • Reynisdóttir I, Polyak K, Iavarone A, Massague J (1995) Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-b. Genes Dev 9:1831-1845. doi: 10.1101/gad.9.15.1831
    • (1995) Genes Dev , vol.9 , pp. 1831-1845
    • Reynisdóttir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 20
    • 33750903389 scopus 로고    scopus 로고
    • Requirement for pre-existing of p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation
    • doi: 10.1007/s11010-006-9206-7
    • Tang JJ, Shen C, Lu YJ (2006) Requirement for pre-existing of p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation. Mol Cell Biochem 291:139-144. doi: 10.1007/s11010-006-9206-7
    • (2006) Mol Cell Biochem , vol.291 , pp. 139-144
    • Tang, J.J.1    Shen, C.2    Lu, Y.J.3
  • 21
    • 0033775972 scopus 로고    scopus 로고
    • Involvement of cyclin-dependent kinases in doxorubicin-induced apoptosis in human tumor cells
    • doi: 10.1002/1098-2744(200009)29:13.0.CO;2-A
    • Lu YJ, Tatsuka M, Takebe H, Yagi T (2000) Involvement of cyclin-dependent kinases in doxorubicin-induced apoptosis in human tumor cells. Mol Carcinog 29:1-7 doi: 10.1002/ 1098-2744(200009)29:13.0.CO;2-A
    • (2000) Mol Carcinog , vol.29 , pp. 1-7
    • Lu, Y.J.1    Tatsuka, M.2    Takebe, H.3    Yagi, T.4
  • 22
    • 0032510026 scopus 로고    scopus 로고
    • Mutated p21WAF1/CIP1/SDI1 lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells
    • doi: 10.1038/sj.onc.1201585
    • Lu YJ, Yamagishi N, Yagi T, Takebe H (1998) Mutated p21WAF1/CIP1/SDI1 lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells. Oncogene 16:705-712. doi: 10.1038/ sj.onc.1201585
    • (1998) Oncogene , vol.16 , pp. 705-712
    • Lu, Y.J.1    Yamagishi, N.2    Yagi, T.3    Takebe, H.4
  • 23
    • 33846702026 scopus 로고    scopus 로고
    • Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
    • doi: 10.1158/0008-5472.CAN-06-1608
    • Morrison H, Sperka T, Manent J et al (2007) Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res 67:520-527. doi: 10.1158/0008-5472.CAN-06-1608
    • (2007) Cancer Res , vol.67 , pp. 520-527
    • Morrison, H.1    Sperka, T.2    Manent, J.3
  • 24
    • 27544514090 scopus 로고    scopus 로고
    • Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
    • doi: 10.1083/jcb.200503165
    • Okada T, Lopez-Lago M, Giancotti FG (2005) Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. J Cell Biol 171:361-371. doi: 10.1083/jcb.200503165
    • (2005) J Cell Biol , vol.171 , pp. 361-371
    • Okada, T.1    Lopez-Lago, M.2    Giancotti, F.G.3
  • 25
    • 0029830818 scopus 로고    scopus 로고
    • Sites and types of UV-induced mutations leading to inactivation of the growth-arresting activity in p21 (waf1)(sdi1/cip1/waf1) cDNA
    • doi: 10.1093/carcin/17.11.2343
    • Lu YJ, Yamagishi N, Miyakoshi J et al (1996) Sites and types of UV-induced mutations leading to inactivation of the growth-arresting activity in p21 (waf1)(sdi1/cip1/waf1) cDNA. Carcinogenesis 17:2343-2345. doi: 10.1093/carcin/17.11.2343
    • (1996) Carcinogenesis , vol.17 , pp. 2343-2345
    • Lu, Y.J.1    Yamagishi, N.2    Miyakoshi, J.3
  • 26
    • 14844355090 scopus 로고    scopus 로고
    • The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
    • doi: 10.1128/MCB.25.6.2384-2394.2005
    • Xiao GH, Gallagher R, Shetler J et al (2005) The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol 25:2384-2394. doi: 10.1128/MCB.25.6.2384-2394.2005
    • (2005) Mol Cell Biol , vol.25 , pp. 2384-2394
    • Xiao, G.H.1    Gallagher, R.2    Shetler, J.3
  • 27
    • 33746722720 scopus 로고    scopus 로고
    • Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
    • doi: 10.1038/nature04856
    • Jin H, Sperka Y, Herrlich P, Morrison H (2006) Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 442:576-579. doi: 10.1038/nature04856
    • (2006) Nature , vol.442 , pp. 576-579
    • Jin, H.1    Sperka, Y.2    Herrlich, P.3    Morrison, H.4
  • 28
    • 18744428417 scopus 로고    scopus 로고
    • Inhibition of Ras-mediated activator protein 1 activity and cell growth by merlin
    • Kim H, Lim JY, Kim YH et al (2002) Inhibition of Ras-mediated activator protein 1 activity and cell growth by merlin. Mol Cells 14:108-114
    • (2002) Mol Cells , vol.14 , pp. 108-114
    • Kim, H.1    Lim, J.Y.2    Kim, Y.H.3
  • 29
    • 18044399847 scopus 로고    scopus 로고
    • The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling
    • doi: 10.1016/S1534-5807(01)00009-0
    • Shaw RJ, Paez JG, Curto M et al (2001) The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell 1:63-72. doi: 10.1016/ S1534-5807(01)00009-0
    • (2001) Dev Cell , vol.1 , pp. 63-72
    • Shaw, R.J.1    Paez, J.G.2    Curto, M.3
  • 30
    • 0037059807 scopus 로고    scopus 로고
    • p21-activated kinase links Rac/Cdc42 signaling to merlin
    • doi: 10.1074/jbc.C100553200
    • Xiao GH, Beeser A, Chernoff J, Testa JR (2002) p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem 277:883-886. doi: 10.1074/jbc.C100553200
    • (2002) J Biol Chem , vol.277 , pp. 883-886
    • Xiao, G.H.1    Beeser, A.2    Chernoff, J.3    Testa, J.R.4
  • 31
    • 33645229806 scopus 로고    scopus 로고
    • Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/ Raf-1 complex and inhibition by the NF2 tumor suppressor protein
    • doi: 10.1073/pnas.0510651103
    • Chadee DN, Xu DZ, Hung G et al (2006) Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc Natl Acad Sci USA 103:4463-4468. doi: 10.1073/pnas.0510651103
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4463-4468
    • Chadee, D.N.1    Xu, D.Z.2    Hung, G.3
  • 32
    • 11144229268 scopus 로고    scopus 로고
    • Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE
    • doi: 10.1073/pnas.0405971102
    • Rong LR, Tang XL, Gutmann DH, Ye K (2004) Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE. Proc Natl Acad Sci USA 101:18200-18205. doi: 10.1073/ pnas.0405971102
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 18200-18205
    • Rong, L.R.1    Tang, X.L.2    Gutmann, D.H.3    Ye, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.