Immunohistochemical detection of schwannomin and neurofibromin in vestibular schwannomas, ependymomas and meningiomas

Journal of Neuropathology and Experimental Neurology

Volumn 56, Issue 4, 1997, Pages 382-390

  Huynh, Duong P ^a   Mautner, Victor ^b   Baser, Michael E ^a   Stavrou, D ^c   Pulst, Stefan M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Klinik Ochsenzoll   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Ependymoma; Meningioma; Merlin; Neurofibromatosis 2; Neurofibromin; Schwannoma; Schwannomin

Indexed keywords

NEUROFIBROMIN;

ALLELE; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; DNA DETERMINATION; EPENDYMOMA; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MENINGIOMA; NEURILEMOMA; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; VESTIBULAR SYSTEM;

EID: 1842366662     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199704000-00007     Document Type: Article

References (35)

1. Evans DGR, Huson SM, Donnai D, et al. A genetic study of type 2 neurofibromatosis in the United Kingdom. I. Prevalence, mutation rate, fitness, and confirmation of maternal transmission effect on severity. J Med Genet 1992a;29:841-46
2. Evans DGR, Huson SM, Donnai D, et al. A genetic study of type 2 neurofibromatosis in the United Kingdom. II. Guidelines for genetic counseling. J Med Genet 1992b;29:847-52
3. Martuza RL, Eldridge R. Neurofibromatosis 2: Bilateral acoustic neurofibromatosis. N Engl J Med 1988;318:684-88
4. Rouleau GA, Wertelecki W, Haines JL, et al. Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature 1992;329:246-48
5. Seizinger BR, Monte SDL, Atkins L, Gusella JF, Martuza RL. Molecular genetic approach to human meningioma: Loss of genes on chromosome 22. Proc Natl Acad Sci USA 1987;84:5419-23
6. Fontaine B, Hanson MP, Vonsattel JP, Martuza RL, Gusella JF. Loss of chromosome 22 alleles in human sporadic spinal schwannomas. Ann Neurol 1991;29:183-86
7. Wollt RK, Frazer KA, Jackler RK, Lanser MJ, Pitts LH, Cox DR. Analysis of chromosome 22 deletions in neurofibromatosis type 2-related tumors. Am J Hum Genet 1992;51:478-85
8. Martuza RL, Ojemann RG. Bilateral acoustic neuromas: Clinical aspects, pathogenesis, and treatment. Neurosurgery 1982;10:1-12
9. Sainz J, Huynh DP, Figueroa K, Ragge NK, Baser ME, Pulst SM. Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas. Hum Mol Genet 1994;3: 885-91
10. Sainz J, Figueroa K, Baser ME, Mautner VF, Pulst SM. High frequency of nonsense mutations in the NF2 gene caused by C to T transitions in five CGA codons. Hum Mol Genet 1995;4:137-39
11. Sainz J, Figueroa K, Baser ME, Pulst SM. Identification of three neurofibromatosis type 2 (NF2) gene mutations in vestibular schwannomas. Hum Genet 1996;97:121-23
12. Sainz J, Baser ME, Ragge NK, Nelson RA, Pulst SM. Loss of alleles in vestibular schwannomas: Use of microsatellite markers on chromosome 22. Arch Ontolaryngol Head Neck Surg 1993;119: 1285-88
13. Scoles DR, Baser ME, Pulst SM. A missense mutation in the neurofibromatosis 2 gene occurs in patients with mild and severe phenotypes. Neurology 1996;47:544-46
14. Jacoby LB, MacCollin M, Louis DN, et al. Exon scanning for mutation of the NF2 gene in schwannomas. Hum Mol Genet 1994;3: 413-419
15. Twist EC, Ruttledge MH, Rousseau M, et al. The neurofibromatosis type 2 gene is inactivated in schwannomas. Hum Mol Genet 1994;3:147-51
16. Lekanne Deprez RH, Bianchi AB, Groen NA, et al. Frequent NF2 gene transcript mutations in sporadic meningiomas and vestibular schwannomas. Am J Hum Genet 1994;54:1022-29
17. Ruttledge MH, Sarrazin J, Rangaratnam S, et al. Evidence for the complete inactivation of the NF2 gene in the majority of sporadic menigiomas. Nature Genet 1994;6:180-84
18. Ruttledge MH, Xie YG, Han FY, Peyrard M, Collins PV, Nordenskjold M, Dumanski JP. Deletions on chromosome 22 in sporadic meningioma. Genes, Chromomosomes & Cancer 1994;10:122-30
19. Rubio MP, Correa KM, Ramesh V, et al. Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas. Cancer Res 1994;54:45-47
20. Mautner VF, Tatagiba M, Lindenau M, Funsterer C, Pulst SM, Kluwe L, Zanella FE. Spinal tumors in patients with neurofibromatosis type 2: MR imaging study of frequency, multiplicity, and variety. Am J Roent 1995;165:951-55
21. MacCollin M, Ramesh V, Jacoby LB, et al. Mutational analyses of patients with neurofibromatosis 2. Am J Hum Genet 1994;55: 314-20
22. Merel P, Hoang-Xuan K, Sanson M, et al. Screening for germ-line mutations in the NF2 gene. Genes, Chromosomes and Cancer 1996;12:117-25
23. Rouleau GA, Merel P, Lutchman M, et al. Alteration in a new gene encoding a putative membrane-organizing protein causes neurofibromatosis type 2. Nature 1993;363:515-21
24. Huynh DP, Pulst SM. Neurofibromatosis 2 antisense oligodeoxy-nucleotides induce reversible inhibition of schwannomin synthesis and alteration of cell morphology in STS26T and T98G cells. Oncogene 1996;13:73-84
25. Huynh DP, Lin CT, Pulst SM. Expression of neurofibromin, the neurofibromatosis type 1 gene product: Studies in human neuroblastoma cells and rat brain. Neuros Let 1992;143:233-36
26. Huynh DP, Nechiporuk T, Pulst SM. Differential expression and tissue distribution of Type I and Type II neurofibromin during mouse fetal development. Dev Bio 1994;161:538-51
27. Trofatter JA, MacCollin MM, Rutter JL, et al. A novel moesin-, ezrin-, radixin-like gene is a candidale for the neurofibromatosis 2 tumor suppressor. Cell 1993;72:791-800
28. Huynh DP, Tran TMD, Nechiporuk T, Pulst SM. Expression of neurofibromatosis 2 transcript and gene product during mouse fetal development. Cell Growth & Diff 1996;7:1551-61
29. Daston MM, Scrable H, Nordlund LM, Sturbaum AK, Nissen LM, Ratner N. The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes. Neuron 1992;8:415-28
30. Nordlund ML, Rizvi TA, Brannan CI, Ratner N. Neurofibromin expression and astrogliosis in neurofibrornatosis (type 1) brains. J Neurol Exp Neurol 1995;54:588-600
31. Baser ME, Ragge NK, Riccardi VM, Ganz B, Janus T, Pulst SM. Phenotypic variability in monozygotic twins with neurofibromatosis 2. Am J Med Genet 1996;64:563-67
32. Kluwe L, Mautner VF. A missense mutation in the NF2 gene results in moderate and mild clinical phenotypes of neurofibromatosis type 2. Hum Genet 1996;97:224-27.
33. Rubinstein LJ. Tumors of the central nervous system. Armed Forces Institute of Pathology 1972:104-19
34. Lekane-Deprez RH, Riegman PH, Groen NA, et al. Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. Oncogene 1995;10:1521-28
35. Pulst SM, Fain P, Rouleau GA, Sieb JA. Familial meningioma is not allelic to NF2. Neurology 1993;43:2096-98