Role of aquaporin-4 in cerebral edema and stroke

Handbook of Experimental Pharmacology

Volumn 190, Issue , 2009, Pages 159-170

  Manley, Geoffrey T ^a   Zador, Zsolt ^b   Stiver, Shirley ^b   Wang, Vincent ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 1; AQUAPORIN 4; AQP4 PROTEIN, MOUSE; UNCLASSIFIED DRUG; WATER;

BRAIN EDEMA; BRAIN HEMORRHAGE; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR ACCIDENT; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; STROKE; ANIMAL; DISEASE MODEL; DRUG EFFECT; ELECTROLYTE BALANCE; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; PATHOPHYSIOLOGY;

ANIMALS; AQUAPORIN 4; BRAIN EDEMA; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, KNOCKOUT; STROKE; WATER; WATER-ELECTROLYTE BALANCE;

EID: 61449306769     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-79885-9_7     Document Type: Review

References (49)

1. Amiry-Moghaddam M, Otsuka T, Hurn PD, et al. (2003a) An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci U S A 100:2106-2111
2. Amiry-Moghaddam M, Williamson A, Palomba M, et al. (2003b) Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. Proc Natl Acad Sci U S A 100:13615-13620
3. Amiry-Moghaddam M, Frydenlund DS, Ottersen OP (2004a) Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transport. Neuroscience 129:999-1010
4. Amiry-Moghaddam M, Xue R, Haug FM, et al. (2004b) Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB J 18:542-544
5. Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001 Oct 1;21(19):7724-32
6. Bardutzky J, Schwab S (2007) Antiedema therapy in ischemic stroke. Stroke 38:3084-3094
7. Bereczki D, Liu M, Prado GF, Fekete I (2000) Cochrane report: a systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage. Stroke 31:2719-2722
8. Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley GT (2006) Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia 53:631-636
9. Brown RC, Davis TP (2002) Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke. Stroke 33:1706-1711
10. Castejon OJ (1984) Formation of transendothelial channels in traumatic human brain edema. Pathol Res Pract 179:7-12
11. Connors NC, Kofuji P (2002) Dystrophin Dp71 is critical for the clustered localization of potassium channels in retinal glial cells. J Neurosci 22:4321-4327
12. Figueroa BE, Keep RF, Betz AL, Hoff JT (1998) Plasminogen activators potentiate thrombininduced brain injury. Stroke 29:1202-1207; discussion 1208
13. Fort PE, Sene A, Pannicke T, et al. (2008) Kir4.1 and AQP4 associate with Dp71- and utrophin- DAPs complexes in specific and defined microdomains of Muller retinal glial cell membrane.Glia 56:597-610
14. Goldstein L, Teng ZP, Zeserson E, Patel M, Regan RF (2003) Hemin induces an iron-dependent, oxidative injury to human neuron-like cells. J Neurosci Res 73:113-121
15. Hacke W, Schwab S, Horn M, Spranger M, De Georgia M, von Kummer R (1996) 'Malignant' middle cerebral artery territory infarction: clinical course and prognostic signs. Arch Neurol 53:309-315
16. Hara-Chikuma M, Verkman AS (2006) Physiological roles of glycerol-transporting aquaporins: the aquaglyceroporins. Cell Mol Life Sci 63:1386-1392
17. Hua Y, Xi G, Keep RF, Hoff JT (2000) Complement activation in the brain after experimental intracerebral hemorrhage. J Neurosurg 92:1016-1022
18. Klatzo I (1967) Presidental address. Neuropathological aspects of brain edema. J Neuropathol Exp Neurol 26:1-14
19. Lee KR, Betz AL, Keep RF, Chenevert TL, Kim S, Hoff JT (1995) Intracerebral infusion of thrombin as a cause of brain edema. J Neurosurg 83:1045-1050
20. Manley GT, Fujimura M, Ma T, et al. (2000) Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159-163
21. Manley GT, Binder DK, Papadopoulos MC, Verkman AS (2004) New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Neuroscience 129:983-991
22. Matsuoka H, Hamada R (2002) Role of thrombin in CNS damage associated with intracerebral haemorrhage: opportunity for pharmacological intervention? CNS Drugs 16:509-516
23. Nagelhus EA, Mathiisen TM, Ottersen OP (2004) Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1. Neuroscience 129:905-913
24. Neely JD, Amiry-Moghaddam M, Ottersen OP, Froehner SC, Agre P, Adams ME (2001) Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proc Natl Acad Sci U S A 98:14108-14113
25. Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP (1997) Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 17:171-180
26. Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT (2005) Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J 19:76-78
27. Oshio K, Watanabe H, Yan D, Verkman AS, Manley GT (2006) Impaired pain sensation in mice lacking aquaporin-1 water channels. Biochem Biophys Res Commun 341:1022-1028
28. Padmawar P, Yao X, Bloch O, Manley GT, Verkman AS (2005) K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nat Methods 2:825-827
29. Papadopoulos MC, Verkman AS (2005) Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem 280:13906-13912
30. Papadopoulos M, Saadoun S, Krishna S, Bell B, Davies D (2002) The aquaporin-1 water channel protein is abnormally expressed in oedematous human brain tumours. J Anat 200:531-532
31. Papadopoulos MC, Manley GT, Krishna S, Verkman AS (2004) Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J 18:1291-3
32. Peters MF, O'Brien KF, Sadoulet-Puccio HM, Kunkel LM, Adams ME, Froehner SC (1997) betadystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations. J Biol Chem 272:31561-31569
33. Rash JE, Yasumura T, Hudson CS, Agre P, Nielsen S (1998) Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc Natl Acad Sci U S A 95:11981-11986
34. Ribeiro Mde C, Hirt L, Bogousslavsky J, Regli L, Badaut J (2006) Time course of aquaporin expression after transient focal cerebral ischemia in mice. J Neurosci Res 83:1231-1240
35. Rincon F, Mayer SA (2004) Novel therapies for intracerebral hemorrhage. Curr Opin Crit Care 10:94-100
36. Saadoun S, Papadopoulos MC, Davies DC, Krishna S, Bell BA (2002) Aquaporin-4 expression is increased in oedematous human brain tumours. J Neurol Neurosurg Psychiatry 72:262-265
37. Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS (2005a) Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 434:786-792
38. Saadoun S, Papadopoulos MC,Watanabe H, Yan D, Manley GT, Verkman AS (2005b) Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci 118:591-598
39. Satpathy M, Gallagher P, Lizotte-Waniewski M, Srinivas SP (2004) Thrombin-induced phosphorylation of the regulatory light chain of myosin II in cultured bovine corneal endothelial cells. Exp Eye Res 79:477-486
40. Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V (2007) Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol 6:258-268
41. Vajda Z, Pedersen M, Fuchtbauer EM, et al. (2002) Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Proc Natl Acad Sci U S A 99:13131-13136
42. Verkman AS (2005) More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci 118:3225-3232
43. Wang X, Mori T, Sumii T, Lo EH (2002) Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke 33:1882-1888
44. Weis SM, Cheresh DA (2005) Pathophysiological consequences of VEGF-induced vascular permeability. Nature 437:497-504
45. Worton R (1995) Muscular dystrophies: diseases of the dystrophin-glycoprotein complex. Science (New York, NY) 270:755-756
46. Xi G, Keep RF, Hoff JT (2006) Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 5:53-63
47. Yang B, Zador Z, Verkman AS (2008) Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. J Biol Chem 283:15280-15286
48. Zador Z, Bloch O, Yao X, Manley GT (2007) Aquaporins: role in cerebral edema and brain water balance. Prog Brain Res 161:185-194
49. Zsolt Zador MD, Xiaoming Yao MD, Ph.D., and Geoffrey T Manley MD, Ph.D. Role of Aquaporins in Non-synaptic Mechanisms of Epilepsy Encyclopedia of Basic Epilepsy Research Ed. Schwartzkroin, P., Elsevier, Amsterdam (In Press)