Dose-dependent effects of genistein and daidzein on protein metabolism in porcine myotube cultures

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 3, 2009, Pages 852-857

  Rehfeldt, Charlotte ^a   Kalbe, Claudia ^a   Nürnberg, Gerd ^a   Mau, Marcus ^a,b  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Differentiation; Estrogen receptor; Isoflavone; Porcine myoblast; Skeletal muscle

Indexed keywords

SUS;

DAIDZEIN; ESTRADIOL; GENISTEIN; ISOFLAVONE DERIVATIVE; MUSCLE PROTEIN;

ANIMAL; ARTICLE; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; METABOLISM; NEWBORN; SKELETAL MUSCLE; SWINE;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; GENISTEIN; ISOFLAVONES; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; SWINE;

EID: 61449214296     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf803039b     Document Type: Article

References (38)

1. Dixon, R. A.; Ferreira, D. Genistein. Phytochemistry 2002, 60, 205-211.
2. Setchell, K. D. R.; Brown, N. M.; Lydeking-Olsen, E. The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J. Nutr. 2002, 132, 3577-3584.
3. Whitten, P. L.; Patisaul, H. B. Cross-species and interassay comparisons of phytoestrogen action. Environ. Health Perspect. 2001, 109 (Suppl. 1), 5-20.
4. Urpi-Sarda, M.; Morand, C.; Besson, C.; Kraft, G.; Viala, D.; Scalbert, A.; Besle, J. M.; Manach, C. Tissue distribution of isoflavones in ewes after consumption of red clover silage. Arch. Biochem. Biophys. 2008, 476, 205-210.
5. Ren, M. Q.; Kuhn, G.; Wegner, J.; Chen, J. Isoflavones, substances with multi-biological and clinical properties. Eur. J. Nutr 2001, 40, 135-46.
6. Kinjo, J.; Tsuchihashi, R.; Morito, K.; Hirose, T.; Aomori, T.; Nagao, T.; Okabe, H.; Nohara, T.; Masamune, Y. Interactions of phytoestrogens with estrogen receptors ∞ and β (III). Estrogenic activities of soy isoflavone aglycones and their metabolites isolated from human urine. Biol. Pharm. Bull. 2004, 27, 185-188.
7. Payne, R. L.; Bidner, T. D.; Southern, L. L.; Geaghan, J. P. Effects of dietary soy isoflavones on growth; carcass traits; and meat quality in growing-finishing pigs. J. Anim. Sci. 2001, 79, 1230-1239.
8. Zhengkang, H.; Wang, G.; Yao, W.; Zhu, W. Y. Isoflavonic phytoestrogens - new prebiotics for farm animals, a review on research in China. Curr. Issues Intest. Microbiol. 2006, 7, 53-60.
9. Rehfeldt, C.; Adamovic, I.; Kuhn, G. Effects of dietary daidzein supplementation of pregnant sows on carcass and meat quality and skeletal muscle cellularity of the progeny. Meat Sci. 2007, 75, 103-111.
10. Mau, M.; Kalbe, C.; Viergutz, T.; Rehfeldt, C. Effects of dietary isoflavones on proliferation and DNA integrity of myoblasts derived from newborn piglets. Pediatr. Res. 2008, 63, 39-45.
11. Akiyama, T.; Ishida, J.; Nakagawa, S.; Ogawara, H.; Watanabe, S.; Itoh, N.; Shibuya, M.; Fukami, Y. Genistein; a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 1987, 262, 5592-5595.
12. Matsukawa, Y.; Marui, N.; Sakai, T.; Satomi, Y.; Yoshida, M.; Matsumoto, K.; Nishino, H.; Aoike, A. Genistein arrests cell-cycle progression at G(2)-M. Cancer Res. 1993, 53, 1328-1331.
13. Chen, A. C.; Donovan, S. M. Genistein at a concentration present in soy infant formula inhibits Caco-2BBe cell proliferation by causing G2/M cell cycle arrest. J. Nutr. 2004, 134, 1303-1308.
14. Yu, Z. L.; Li, W. J.; Liu, F. Y. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. Cancer Lett. 2004, 215, 159-166.
15. Ji, S.; Willis, G. M.; Frank, G. R.; Cornelius, S. G.; Spurlock, M. E. Soybean isoflavones; genistein and genistin; inhibit rat myoblast proliferation; fusion and myotube protein synthesis. J. Nutr. 1999, 129, 1291-1297.
16. Salti, G. I.; Grewal, S; Mehta, R. R.; DasGupta, T. K.; Boddie, A. W.; Constantinou, A. I. Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells. Eur. J. Cancer 2000, 36, 796-802.
17. Markovits, J.; Linassier, C.; Fosse, P.; Couprie, J; Pierre, J.; Jacquemin-Sablon, A.; Saucier, J. M.; LePecq, J. B.; Larsen, A. K. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res. 1989, 49, 5111-5117.
18. Kuhn, G.; Hennig, U.; Kalbe, C.; Rehfeldt, C.; Ren, M. Q.; Moors, S.; Degen, G. H. Growth performance, carcass characteristics and bioavailability of isoflavones in pigs fed soy bean based diets. Arch. Anim. Nutr. 2004, 58, 265-276.
19. Mau, M.; Oksbjerg, N.; Rehfeldt, C. Establishment and conditions for growth and differentiation of a myoblast cell line derived from semimembranosus muscle of newborn piglets. In Vitro Cell Dev. Biol. Anim. 2008, 44, 1-5.
20. Mau, M.; Kalbe, C.; Wollenhaupt, K.; Nürnberg, G.; Rehfeldt, C. IGF-I- and EGF-dependent porcine myoblast proliferation is influenced by the dietary isoflavones genistein and daidzein. Dom. Anim. Endocrinol. 2008, 35, 281-289.
21. Doumit, M. E.; Cook, D. R.; Merkel, R. A. Testosterone up-regulates androgen receptors and decreases differentiation of porcine myogenic satellite cells in vitro. Endocrinol. 1996, 137, 1385-1394.
22. Ballard, F. J. Regulation of protein accumulation in cultured cells. Biochem. J. 1982, 208, 275-287.
23. Harper, J. M. M.; Soar, J. B.; Buttery, P. J. Changes in protein metabolism of ovine primary muscle cultures on treatment with growth hormone; insulin; insulin-like growth factor I or epidermal growth factor. J. Endocrinol. 1987, 112, 87-96.
24. Rehfeldt, C.; Walther, K.; Albrecht, E.; Nürnberg, G.; Renne, U.; Bünger, L. Intrinsic properties of muscle satellite cells are changed in response to long-term selection of mice for different growth traits. Cell Tiss. Res. 2002, 310, 339-348.
25. Peterson, G. L. A simplification of the protein assay method of Lowry et al. Anal. Biochem. 1977, 83, 346-356.
26. Laemmli, U. K. Cleavage of structural proteins during assembly of head of bacteriophage-T4. Nature 1970, 227, 680-685.
27. Kalbe, C.; Mau, M.; Wollenhaupt, K.; Rehfeldt, C. Evidence for estrogen receptor α and β expression in skeletal muscle of pigs. Histochem. Cell Biol. 2007, 127, 95-107.
28. Pfaffl, M. W.; Lange, I. G.; Daxenberger, A.; Meyer, H. H. Tissue-specific expression pattern of estrogen receptors (ER), quantification of ER α and ER β mRNA with real-time RT-PCR. APMIS 2001, 109, 345-355.
29. Liu, G. T.; Zheng, Y. L.; Chen, W. H.; Chen, J.; Han, Z. K. Effect of daidzein fed to pregnant sows on milk production and the levels of hormones in colostrums. J. Nanjing Agric. Univ. 1999, 22, 69-72.
30. Hashimoto, N.; Ogashiwa, M.; Iwashita, S. Role of tyrosine kinase in the regulation of myogenin expression. Eur. J. Biochem. 1995, 227, 379-387.
31. Woo, J. H.; Kim, J. H.; Inhee, M. J.; Kim, H. S. Lipid products of phosphoinositide 3-kinase abrogate genistein-induced fusion inhibition in myoblasts. Eur. J. Pharmacol. 2006, 529, 84-94.
32. Roeder, R. A.; Thorpe, S. D.; Byers, F. M.; Schelling, G. T.; Gunn, J. M. Influence of anabolic agents on protein synthesis and degradation in muscle cells grown in culture. Growth 1986, 50, 485-495.
33. Kalbe, C.; Mau, M.; Rehfeldt, C. Developmental changes and the impact of isoflavones on mRNA expression of IGF-I receptor; EGF receptor and related growth factors in porcine skeletal muscle cell cultures. Growth Horm. IGF Res 2008, 18, 424-433.
34. Roche, J.; Quirke, J. F. The effects of steroid hormones and xenobiotics on growth of farm animals. In Control and Manipulation of Animal Growth; Buttery, P. J., Lindsay, D. B., Haynes, N. B., Eds.; Butterworth: London, U.K.; 1986; p 39.
35. Lanje, K., Ed. Nachhaltige Eiweißversorgung in der Tierernährung; Loccumer Protokoll Nr. 73/00; Rehburg-Loccum, 2001; p 160.
36. Mount, L. E.; Ingram, D. L. The Pig As a Laboratory Animal; Academic Press: New York, 1971; pp 19-120.
37. Moughan, P. J.; Birtles, M. J.; Cranwell, P. D.; Smith, W. C.; Pedraza, M. The piglet as a model animal for studying aspects of digestion and absorption in milk-fed human infants. World Rev. Nutr. Diet. 1992, 67, 40-113.
38. Gu, L.; House, S. E.; Prior, R. L.; Fang, N.; Ronis, M. J.; Clarkson, T. B.; Wilson, M. E.; Badger, T. M. Metabolic phenotype of isoflavones differ among female rats; pigs; monkeys; and women. J. Nutr. 2006, 136, 1215-1221.