Glycodelin in reproductive endocrinology and hormone-related cancer

European Journal of Endocrinology

Volumn 160, Issue 2, 2009, Pages 121-133

  Seppala M ^a   Koistinen, H ^a   Koistinen, R ^a   Hautala, L ^a   Chiu, P C ^b   Yeung, W S ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; GESTAGEN; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; METFORMIN; PLACENTA PROTEIN 14; PROGESTERONE; RELAXIN; GLYCOPROTEIN; PAEP PROTEIN, HUMAN; PLACENTA PROTEIN;

ABORTION; ACROSOME REACTION; APOPTOSIS; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER GRADING; CANCER INHIBITION; CANCER SURVIVAL; ENDOMETRIOSIS; ENDOMETRIUM; ENDOMETRIUM CANCER; ENDOMETRIUM CARCINOMA; FEMALE INFERTILITY; FERTILIZATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SYNTHESIS; GENETIC EPIGENESIS; HORMONAL CARCINOGENESIS; HORMONAL REGULATION; HUMAN; IMMUNOREGULATION; NONHUMAN; OVARY CANCER; OVARY POLYCYSTIC DISEASE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; REVIEW; SPERMATOZOON CAPACITATION; SURVIVAL TIME; TUMOR SUPPRESSOR GENE; UTERUS FUNCTION; ENDOCRINE SYSTEM; FEMALE; MALE; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; REPRODUCTION;

ENDOCRINE SYSTEM; FEMALE; GLYCOPROTEINS; HUMANS; MALE; NEOPLASMS; PREGNANCY; PREGNANCY PROTEINS; REPRODUCTION;

EID: 61449200391     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-08-0756     Document Type: Review

References (124)

1. Julkunen M, Seppälä M & Jänne OA. Complete amino acid sequence of human placental protein 14: a progestone-regulated uterine protein homologous to β-lactoglobulins. PNAS 1988 85 8845-8849.
2. Dell A, Morris HR, Easton R, Panico M, Patankar M, Oehninger S, Koistinen R, Koistinen H, Seppälä M & Clark GF. Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities. Journal of Biological Chemistry 1995 270 24116-24126.
3. Morris HR, Dell A, Easton RL, Panico M, Koistinen H, Koistinen R, Oehninger S, Patankar MS, Seppälä M & Clark GF. Gender specific glycosylation of human glycodelin dictates contraceptive activity. Journal of Biological Chemistry 1996 271 32159-32167.
4. Bolton AE, Pockley AG, Clough KJ, Mowles EA, Stoker RJ, Westwood OMR & Chapman MG. Identification of placental protein 14 as an immunosuppressive factor in human reproduction. Lancet 1987 1 593-595.
5. Okamoto N, Uchida A, Takakura K, Kariya Y, Kanzaki H, Riittinen L, Koistinen R, Seppälä M & Mori T. Suppression by human placental protein 14 of natural killer cell activity. American Journal of Reproductive Immunology 1991 26 137-142.
6. Oehninger S, Coddington CC, Hodgen GD & Seppälä M. Factors affecting fertilization: endometrial placental protein 14 reduces the capacity of human spermatozoa to bind to the human zona pellucida. Fertility and Sterility 1995 63 377-383.
7. Seppälä M & Tiitinen A. Endometrial responses to corpus luteum products in cycles with induced ovulation: theoretical and practical considerations. Human Reproduction 1995 10 67-76.
8. Seppälä M, Bohn H & Tatarinov Y. Glycodelins. Tumor Biology 1998 19 213-220.
9. Kämäräinen M, Julkunen M & Seppälä M. HinfI polymorphism in the human progesterone associated endometrial protein (PAEP) gene. Nucleic Acids Research 1991 19 5092.
10. Chiu PCN, Koistinen R, Koistinen H, Seppälä M, Lee KF & Yeung WSB. Zona binding inhibitory factor-1 from human follicular fluid is an isoform of glycodelin. Biology of Reproduction 2003 69 365-372.
11. Bell SC & Bohn H. Immunohistochemical and biochemical relationship between human pregnancy-associated secreted endometrial alpha 1- and alpha 2-globulins (alpha 1- and alpha 2-PEG) and the soluble placental proteins 12 and 14 (PP12 and PP14). Placenta 1986 7 283-294.
12. Julkunen M, Raikar RS, Joshi SG, Bohn H & Seppälä M. Placental protein 14 and progestagen-dependent endometrial protein are immunologically indistinguishable. Human Reproduction 1986 1 7-8.
13. Vaisse C, Atger M, Potier B & Milgrom E. Human placental protein 14 gene: sequence and characterization of a short duplication. DNA and Cell Biology 1990 9 401-413.
14. Yeung WSB, Lee K-F, Koistinen R, Koistinen H, Seppälä M & Chiu PCN. Roles of glycodelin in modulating sperm function. Molecular and Cellular Endocrinology 2006 250 149-156.
15. Seppälä M, Koistinen H, Koistinen R, Chiu PC & Yeung WS. Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations. Human Reproduction Update 2007 13 275-287.
16. Julkunen M, Wahlström T, Seppälä M, Koistinen R, Koskimies AI, Stenman UH & Bohn H. Detection and localization of placental protein 14-like protein in human seminal plasma and in the male genital tract. Archives of Andrology 1984 12 59-67.
17. Koistinen H, Koistinen R, Dell A, Morris HR, Easton RL, Patankar MS, Oehninger S, Clark GF & Seppälä M. Glycodelin from seminal plasma is a differentially glycosylated form of contraceptive glycodelin-A. Molecular Human Reproduction 1996 2 759-765.
18. Koistinen H, Koistinen R, Kämäräinen M, Salo J & Seppälä M. Multiple forms of messenger ribonucleic acid encoding glycodelin in male genital tract. Laboratory Investigation 1997 76 683-690.
19. Julkunen M, Koistinen R, Sjöberg J, Ruta-nen EM, Wahlström T & Seppälä M. Secretory endometrium synthesizes placental protein 14. Endocrinology 1986 118 1782-1786.
20. Julkunen M, Koistinen R, Suikkari AM, Seppälä M & Jänne OA. Identification by hybridization histochemistry of human endometrial cells expressing mRNAs encoding a uterine β-lactoglobulin homologue and insulin-like growth factor-binding protein-1. Molecular Endocrinology 1990 4 700-707.
21. Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A, Osteen K, Taylor RN, Lessey BA & Giudice LC. Global gene profiling in human endometrium during the window of implantation. Endocrinology 2002 143 2119-2138.
22. Kämäräinen M, Leivo I, Julkunen M & Seppälä M. Localization of progesterone-associated endometrial protein mRNA by in-situ hybridisation in human pregnancy deciduas, endometriosis and borderline endometrioid adenoma. Journal of Molecular Endocrinology 1993 10 71-77.
23. Li TC, Dalton C, Hunjan KS, Warren MA & Bolton AE. The correlation of placental protein 14 concentrations in uterine flushing and endometrial morphology in the peri-implantation period. Human Reproduction 1993 8 1923-1927.
24. Julkunen M, Rutanen EM, Koskimies AI, Ranta T, Bohn H & Seppälä M. Distribution of placental protein 14 in tissues and body fluids during pregnancy. British Journal of Obstetrics and Gynaecology 1985 92 1145-1151.
25. Riittinen L, Julkunen M, Seppälä M, Koistinen R & Huhtala ML. Purification and characterization of endometrial protein PP14 from mid-trimester amniotic fluid. Clinica Chimica Acta 1989 184 19-30.
26. Tse JYM, Chiu PCN, Lee KF, Seppala M, Koistinen H, Koistinen R, Yao YQ & Yeung WSB. The synthesis and fate of glycodelin in human ovary during folliculogenesis. Molecular Human Reproduction 2002 8 142-148.
27. Chiu PCN, Chung M-K, Koistinen R, Koistinen H, Seppälä M, Ho PC, Ng EHY, Lee KF & Yeung WSB. Cumulus oophorus-associated glycodelin-C displaces sperm bound glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding. Journal of Biological Chemistry 2007 282 5378-5388.
28. Julkunen M, Wahlström T & Seppälä M. Human fallopian tube contains placental protein 14. American Journal of Obstetrics and Gynecology 1986 154 1076-1079.
29. Laird SM, Hill CJ, Warren MA, Tuckerman EM & Li TC. The production of placental protein 14 by human uterine tubal epithelial cells in culture. Human Reproduction 1995 10 1346-1351.
30. Maguiness SD, Shrimanker K, Djahanbakhch O, Deeks JJ, Teisner B & Grudzinskas JG. In vitro synthesis of total protein and placental protein 14 by the fallopian tube mucosa: variation in relation to anatomical site, the ovarian cycle and the menopause. Human Reproduction 1993 8 678-683.
31. Kämäräinen M, Halttunen M, Koistinen R, Boguslawsky von K, Smitten von K, Andersson LC & Seppälä M. Expression of glycodelin in human breast and breast cancer. International Journal of Cancer 1999 83 738-742.
32. Kämäräinen M, Seppälä M, Virtanen I & Andersson LC. Expression of glycodelin in MCF-7 breast cancer cells induces epithelial differentiation into organized acinar epithelium. Laboratory Investigation 1997 77 565-573.
33. Kämäräinen M, Leivo I, Koistinen R, Julkunen M, Karvonen U, Rutanen EM & Seppälä M. Normal human ovary and ovarian tumors express glycodelin, a glycoprotein with immunosuppressive and contraceptive properties. Evidence from immunohistochemical staining and in situ hybridization. American Journal of Pathology 1996 148 1435-1443.
34. Morrow DM, Xiong N, Getty RR, Ratajczak MZ, Morgan D, Seppälä M, Riittinen L, Gewirtz AM & Tykocinski ML. Hematopoietic placental protein 14. An immunosuppressive factor in cells of the megakaryocytic lineage. American Journal of Pathology 1994 145 1485-1495.
35. Kämäräinen M, Riittinen L, Seppälä M, Palotie A & Andersson LC. Progesterone-associated endometrial protein - a constitutive marker of human erythroid precursors. Blood 1994 84 467-473.
36. Julkunen M, Apter D, Seppälä M, Stenman UH & Bohn H. Serum levels of placental protein 14 reflect ovulation in nonconceptional menstrual cycles. Fertility and Sterility 1986 45 47-50.
37. Stewart DR, Erikson MS, Erikson ME, Nakajima ST, Overstreet JW, Lasley BL, Amento EP & Seppälä M. The role of relaxin in glycodelin secretion. Journal of Clinical Endocrinology and Metabolism 1997 82 839-846.
38. Seppälä M, Taylor RN, Koistinen H, Koistinen R & Milgrom E. Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. Endocrine Reviews 2002 23 401-430.
39. Critchley HO, Chard T, Olajide F, Davies MC, Hughes S, Wang HS, Lieberman BA & Anderson DC. Role of the ovary in the synthesis of placental protein-14. Journal of Clinical Endocrinology and Metabolism 1992 75 97-100.
40. Reshef E, Lei ZM, Rao CV, Pridham DD, Chegini N & Luborsky JL. The presence of gonadotropin receptors in nonpregnant human uterus, human placenta, fetal membranes, and decidua. Journal of Clinical Endocrinology and Metabolism 1990 70 421-430.
41. Fazleabas AT, Donnelly KM, Srinivasan S, Fortman JD & Miller JB. Modulation of the baboon (Papio anubis) uterine endometrium by chorionic gonadotropin during the period of uterine receptivity. PNAS 1999 96 2543-2548.
42. Tseng L, Zhu HH, Mazella J, Koistinen H & Seppälä M. Relaxin stimulates glycodelin mRNA and protein concentrations in human endometrial glandular epithelial cells. Molecular Human Reproduction 1999 5 372-375.
43. Taylor RN, Savouret J-F, Vaisse C, Vigne J-L, Ryan I, Hornung D, Seppälä M & Milgrom E. Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells. Journal of Clinical Endocrinology and Metabolism 1998 83 4006-4012.
44. Gao J, Mazella J, Seppala M & Tseng L. Ligand activated HPR modulates the glycodelin promoter activity through the Sp1 sites in human endometrial adenocarcinoma cells. Molecular and Cellular Endocrinology 2001 176 97-102.
45. Bolden JE, Peart MJ & Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nature Reviews. Drug Discovery 2006 5 769-784.
46. Uchida H, Maruyama T, Nagashima T, Asada H & Yoshimura Y. Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. Endocrinology 2005 146 5365-5373.
47. Uchida H, Maruyama T, Ohta K, Ono M, Arase T, Kagami M, Oda H, Kajitani T, Asada H & Yoshimura Y. Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation. Human Reproduction 2007 22 2615-2622.
48. Jaffe RC, Ferguson-Gottschall SD, Gao W, Beam C & Fazleabas AT. Histone deacetylase inhibition and progesterone act synergistically to stimulate baboon glycodelin gene expression. Journal of Molecular Endocrinology 2007 38 401-407.
49. Clark GF, Oehninger S, Patankar MS, Koistinen R, Dell A, Morris HR, Koistinen H & Seppälä M. A role for glycoconjugates in human development: the human feto-embryonic defense system hypothesis. Human Reproduction 1996 11 467-473.
50. Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, Schatz F, Masch R, Lockwood CJ, Schachter AD, Park PJ & Strominger JL. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. Journal of Experimental Medicine 2003 198 1201-1212.
51. Chiu PCN, Koistinen R, Koistinen H, Seppälä M, Lee KF & Yeung WSB. Binding of zona binding inhibitory factor-1 (ZIF-1) from human follicular fluid on spermatozoa. Journal of Biological Chemistry 2003 278 13570-13577.
52. Chiu PCN, Tsang HY, Chung MK, Koistinen R, Koistinen H, Seppälä M, Lee KF & Yeung WSB. Glycodelin-S in human seminal plasma reduces cholesterol efflux and capacitation of spermatozoa. Journal of Biological Chemistry 2005 280 25580-25589.
53. Rachmilewitz J, Borovsky Z, Riely GJ, Miller M & Tykocinski ML. Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45. Journal of Biological Chemistry 2003 278 14059-14065.
54. SundarRaj S, Mukhopadhyay D & Karande AA. Glycodelin A triggers mitochondrial stress and apoptosis in T cells by a mechanism distinct and independent of TCR signalling. Molecular Immunology 2008 45 2391-2400.
55. Seppälä M, Koistinen H, Koistinen R, Dell A, Morris HR, Oehninger S & Clark GF. Glycodelins as regulators of early events of reproduction. Clinical Endocrinology 1997 46 381-386.
56. Rachmilewitz J, Riely GJ & Tykocinski ML. Placental protein 14 functions as a direct T-cell inhibitor. Cellular Immunology 1999 191 26-33.
57. Okamoto N, Uchida A, Takakura K, Kariya Y, Kanzaki H, Riittinen L, Koistinen R, Seppälä M & Mori T. Suppression by human placental protein 14 of natural killer cell activity. American Journal of Reproductive Immunology 1991 26 137-142.
58. Mukhopadhyay D, Sundereshan S, Rao C & Karande AA. Placental protein 14 (PP14) induces apoptosis in T cells, but not in monocytes. Journal of Biological Chemistry 2001 276 28268-28273.
59. Mukhopadhyay D, SundarRaj S, Alok A & Karande AA. Glycodelin-A, not glycodelin-S, is apoptotically active. Relevance of sialic acid modification. Journal of Biological Chemistry 2004 279 8577-8584.
60. Yaniv E, Borovsky Z, Mishan-Eisenberg G & Rachmilewitz J. Placental protein 14 regulates selective B cell responses. Cellular Immunology 2003 222 156-163.
61. Jayachandran R, Radcliffe CM, Royle L, Harvey DJ, Dwek RA, Rudd PM & Karande AA. Oligosaccharides modulate apoptotic activity of glycodelin. Glycobiology 2006 16 1052-1063.
62. Poornima BL & Karande AA. Differential sialylation regulates the apoptotic activity of glycodelin A. FEBS Letters 2007 581 4366-4370.
63. Tee MK, Vigne JL, Yu J & Taylor RN. Natural and recombinant human glycodelin activates a proapoptitic gene cascade in monocyte cells. Journal of Leukocyte Biology 2008 83 843-852.
64. Alok A, Mukhopadhyay D & Karande AA. Glycodelin A, an immunomodulatory protein in the endometrium, inhibits proliferation and induces apoptosis in monocytic cells. International Journal of Biochemistry and Cell Biology, 2008 (Epub ahead of print).
65. Matsuura F, Ohta M, Ionnou YA & Desnick RJ. Human alpha-galactosidase A: characterization of the N-linked oligosaccharides on the intracellular and secreted glycoforms overexpressed by Chinese hamster ovary cells. Glycobiology 1998 8 329-339.
66. Van den Nieuwenhof IM, Koistinen H, Easton RL, Koistinen R, Kämäräinen M, Morris HR, vanDie I, Seppälä M, Dell A, VanDenEijnden DH, Kämäräinen M, Morris HR, van Die I, Seppälä M, Dell A & Van Den Eijnden DH. Recombinant glycodelin carrying the same type of glycan structures as contraceptive glycodelin-A can be produced in human kidney 293 cells but not in Chinese hamster ovary cells. European Journal of Biochemistry 2000 267 4753-4762.
67. Gneist N, Keck G, Zimmermann A, Trinkaus I, Kuhlisch E & DistlerW. Glycodelin binding to human ejaculated spermaatozoa is correlated with sperm morphology. Fertility and Sterility 2007 88 1358-1365.
68. Mandelin E, Koistinen H, Koistinen R, Affandi B & Seppälä M. Levonorgestrel-releasing IUD-wearing women express contraceptive glycodelin-A in endometrium during midcycle: another contraceptive mechanism? Human Reproduction 1997 12 2671-2675.
69. Koistinen H, Koistinen R, Seppälä M, Burova TV, Choiset Y & Hærtlé T. Glycodelin and ß-lactoglobulin, lipocalins with high structural similarity, differ in ligand binding properties. FEBS Letters 1999 450 158-162.
70. Chiu PCN, Chung M-K, Koistinen R, Koistinen H, Seppälä M, Lee KF, Ho PC, Ng EH & Yeung WSB. Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. Journal of Cell Science 2007 120 33-44.
71. Nikas G. Endometrial receptivity: changes in cell-surface morphology. Seminars in Reproductive Medicine 2000 18 229-235.
72. Stavreus-Evers A, Mandelin E, Koistinen R, Aghajnova L, Hovatta O & Seppälä M. Glycodelin is present in pinopodes of receptive phase human endometrium, and its presence is associated with downregulation of progesterone receptor B. Fertility and Sterility 2006 85 1803-1811.
73. Damario MA, Lesnick TG, Lessey BA, Kowalik A, Mandelin E, Seppälä M & Rosenwaks Z. Endometrial markers of uterine receptivity utilizing the donor oocyte model. Human Reproduction 2001 16 1893-1899.
74. Aplin J, Self M, Graham R, Hey NA, Behzad F & Campbell S. The endometrial cell surface and implantation. Expression of polymorphic mucin (MUC-1) and adhesion molecules during the endometrial cycle. Annals of the New York Academy of Sciences 1994 734 103-121.
75. Meseguer M, Aplin J, Caballero-Campo P, O'Connor JE, Martin JC, Remohi J, Pellicer A & Simón C. Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biology of Reproduction 2001 64 590-601.
76. Westergaard LG, Wiberg N, Andersen CY, Laursen SB, Kliem A, Westergaard JG & Teisner B. Circulating concentrations of placenta protein 14 during the natural menstrual cycle in women significantly reflect endometrial receptivity to implantation and pregnancy during successive assisted reproduction cycles. Human Reproduction 1998 13 2612-2619.
77. Brown SE, Mandelin E, Oehninger S, Toner JP, Seppala M & Jones HW Jr. Endometrial glycodelin A expression in the liteal phase of stimulated ovarian cycles. Fertility and Sterility 2000 74 130-133.
78. Horcajadas JA, Riesewijk A, Polman J, van Os R, Pellicer A, Mosselman S & Simon C. Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Molecular Human Reproduction 2005 11 195-205.
79. Horowitz IR, Cho CH, Song MQ, Flowers LC, Santanam N, Parthasarathy S & Ramachandran S. Increased glycodelin levels in glycecological malignancies. International Journal of Gynecological Cancer 2001 11 173-179.
80. Poddar AS, Kim JG, Gill KP, Bates BN, Santanam N, Rock JA, Murphy AA & Parthasarathy S. Generation and characterization of a polyclonal antipeptide antibody to human glycodelin. Fertility and Sterility 1998 69 543-548.
81. Mylonas I, Jeschke U, Kunert-Keil C, Shabani N, Dian D, Bauerfeind I, Kuhn C, Kupka MS & Friese K. Glycodelin A is expressed differentially in normal human endometrial tissue throughout the menstrual cycle by immunohistochemistry and in situ hybridization. Fertility and Sterility 2006 86 1488-1497.
82. Mackenna A, Li TC, Dalton C, Bolton A & Cooke I. Placental protein 14 levels in uterine flushing and plasma of women with unexplained infertility. Fertility and Sterility 1993 59 577-582.
83. Klentzeris LD, Bulmer JN, Seppälä M, Li TC, Warren MA & Cooke ID. Placental protein 14 in cycles with normal and retarded endometrial differentiation. Human Reproduction 1994 9 394-398.
84. Dalton CF, Laird SM, Estdale SE, Saravelos HG & Li TC. Endometrial protein PP14 and CA-125 in recurrent miscarriage patients: correlation with pregnancy outcome. Human Reproduction 1998 13 3197-3202.
85. Tulppala M, Julkunen M, Tiitinen A, Stenman U-H & Seppälä M. Habitual abortion is accompanied by low serum levels of placental protein 14 in the luteal phase of the fertile cycle. Fertility and Sterility 1995 63 792-795.
86. Toth B, Roth K, Kunert-Keil C, Scholz C, Schulze S, Mylonas I, Friese K & Jeschke U. Glycodelin protein and mRNA is down-regulated in human first trimester abortion and partially upregulated in mole pregnancy. Journal of Histochemistry and Cytochemistry 2008 56 477-485.
87. Jakubowicz DJ, Essah PA, Seppala M, Jakubowicz S, Koistinen R & Nestler JE. Reduced glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy. Journal of Clinical Endocrinology and Metabolism 2004 89 833-839.
88. Jakubowicz DJ, Seppälä M, Jakubowicz S, Rodriguez-Armas O, Rivas-Santiago A, Koistinen H, Koistinen R & Nestler JE. Insulin reduction with metformin increases luteal-phase serum glycodelin and insulin-like growth factor binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 2001 86 1126-1133.
89. Seppälä M, Mandelin E, Koistinen R, Bergholm R, Tiikkainen M & Yki-Järvinen H. Glycodelin responses to hyperinsulinaemic clamp vary according to basal glycodelin concentration. Clinical Endocrinology 2005 62 611-615.
90. Attia GR, Zeltoun K, Edwards D, Johns A, Carr BR & Bulun SE. Progesterone receptor isoform A but not B is expressed in endometriosis. Journal of Clinical Endocrinology and Metabolism 2000 85 2897-2902.
91. Barnhart K, Dunsmoor-Su R & Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertility and Sterility 2002 77 1148-1155.
92. Kao LC, Germeyer A, Tulac S, Lobo S, Yang JP, Taylor RN, Osteen K, Lessey BA & Giudice LC. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology 2003 144 2870-2981.
93. Meola J, Dentillo DB, Silva RE, Ferriani RA, Veiga LC, Paro de Paz CC & Martelli L. Glycodelin expression in the endometrium of healthy women and in the eutopic and ectopic endometrium of women with endometriosis. Fertility and Sterility, 2008 (Epub ahead of print).
94. Cornillie FJ, Lauweryns JM, Seppälä M, Riittinen L & Koninckx PR. Expression of endometrial protein PP14 in pelvic and ovarian endometriotic implants. Human Reproduction 1991 10 1411-1415.
95. Telimaa S, Kauppila A, Rönnberg L, Suikkari A-M & Seppälä M. Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis. Suppression by treatment with danazol and high-dose medroxyprogesterone acetate. American Journal of Obstetrics and Gynecology 1989 161 866-871.
96. Koninckx PR, Riittinen L, Seppälä M & Cornillie FJ. CA-125 and placen-tal protein 14 concentrations in plasma and peritoneal fluid of women with deeply in-filtrating pelvic endometriosis. Fertility and Sterility 1992 57 523-530.
97. Coddington CC, Oehninger S, Cunningham DS, Hansen K, Sueldo C & Hodgen GD. Peritoneal fluid from patients with endometriosis decreases sperm binding to the zona pellucida in the hemizona assay: a preliminary report. Fertility and Sterility 1992 57 783-786.
98. Wei Q, St Clair JB, Fu T, Stratton P & Nieman LK. Reduced expression of biomarkers associated with the implantation window in women with endometriosis. Fertility and Sterility, 2008 (Epub ahead of print).
99. Chlebowski RT, Hendrix SL, Langer RD, Stefanick ML, Gass M, Lane D, Rodabough RJ, Gillian MA, Cyr MG, Thomson CA, Khandekar J, Petrovich H, McTiernan A & WHI Investigators. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative randomised trial. Journal of the American Medical Association 2003 289 3243-3253.
100. Stefanick ML, Anderson GL, Margolis KL, Hendrix SL, Rodabough RJ, Paskett ED, Lane DS, Hubbell FA, Assaf AR, Sarto GE, Schenken RS, Yasmeen S, Lessin L, Chlebowski RT & WHI Investigators. Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal womenn with hysterectomy. Journal of the American Medical Association 2006 295 1647-1657.
101. Speroff L. A clinicians review of the WHI-related literature. International Journal of Fertility and Women's Medicine 2004 49 252-267.
102. Creasman WT. Breast cancer: the role of hormone therapy. Seminars in Reproductive Medicine 2005 23 167-171.
103. Dolled-Filhart M, McCabe A, Giltnane J, Cregger M, Camp RL & Rimm DL. Quantitative in situ analysis of β-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Research 2006 66 5487-5494.
104. Hautala L, Koistinen R, Seppälä M, Bützow R, Stenman UH, Laakkonen P & Koistinen H. Glycodelin reduces breast cancer xenograft growth in vivo. International Journal of Cancer 2008 123 2279-2284.
105. Munster PN, Troso-Sandoval T, Rosen N, Rifkind R, Marks PA & Richon VM. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. Cancer Research 2001 61 8492-8497.
106. Mann BS, Johnson JR, Cohen MH, Justice R & Pazdur R. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist 2007 12 1247-1252.
107. Jeschke U, Mylonas I, Kunert-Keil C, Dazert E, Shabani N, Werling M, Kuhn C, Janni W, Gerber B & Friese K. Expression of glycodelin protein and mRNA in human ductal breast cancer carcinoma in situ, invasive ductal carcinomas, their lymph node and distant metastases, and ductal carcinomas with recurrence. Oncology Reports 2005 13 413-419.
108. Ziel HK & Finke WD. Increased risk of endometrial carcinoma among users of conjugated estrogens. New England Journal of Medicine 1975 293 1167-1170.
109. Jick SS, Walker AM & Jick H. Estrogens, progesterone, and endometrial cancer. Epidemiology 1993 4 20-24.
110. Navaratnarajah R, Pillay OC & Hardiman P. Polycystic ovary syndrome and endometrial cancer. Seminars in Reproductive Medicine 2008 26 62-71.
111. Benedet JL, Bender H, Jones H III, Ngan HY & Pecorelli S. FigO staging classifications and clinical practice guidelines in the management of gynaecologic cancers. FigO Committee of Gynecologic Oncology. International Journal of Gynecology and Obstetrics 2000 70 209-262.
112. Chatzaki E, Gallaher CJ, Iles RK, Ind TE, Nouri AM, Bax CM & Grudzinskas JG. Characterisation of the differential expression of marker antigens by normal and malignant endometrial epithelium. British Journal of Cancer 1994 69 1010-1014.
113. Arnold JT, Lessey BA, Seppala M & Kaufman DG. Effect of normal endometrial stroma on growth and differentiation in Ishikawa endometrial adenocarcinoma cells. Cancer Research 2002 62 79-88.
114. Koistinen H, Seppälä M, Nagy B, Tapper J, Knuutila J & Koistinen R. Glycodelin reduces carcinoma-associated gene expression in endometrial adenocarcinoma cells. American Journal of Obstetrics and Gynecology 2005 193 1955-1960.
115. Ohta K, Maruyama T, Uchida H, Ono M, Nagashima T, Arase T, Kajitani T, Oda H, Morita M & Yoshimura Y. Glycodelin blocks progression to S phase and inhibits cell growth: a possible progesterone-induced regulator for endometrial epithelial cell growth. Molecular Human Reproduction 2008 14 17-22.
116. Shapiro GI. Cyclin-dependent kinase pathways as targets for cancer treatment. Journal of Clinical Oncology 2006 24 1770-1783.
117. Martin-Hirsch PL, Lilford RJ & Jarvis GJ. Adjuvant progestagen therapy for the treatment of endometrial cancer: review and meta-analyses of published randomised controlled trials. European Journal of Obstetrics, Gynecology, and Reproductive Biology 1996 65 201-207.
118. COSA-NZ-UK Endometrial Cancer Study Groups. Adjuvant medroxyprogesterone acetate in high-risk endometrial cancer. International Journal of Gynecological Cancer 1998 8 387-391.
119. DiSaia P & Creasman W. Epithelial ovarian cancer. Clinical Gynecologic Oncology, 6th edn, pp 289-350. Mosby, 2002.
120. Bast RC Jr, Krug TL, Schaetzl E, Lavin P, Niloff JM, Greber TF, Zurawski VR Jr & Knapp RC. Monitoring human ovarian carcinoma with a combination of CA 125, CA 19-9, and carcinoembryonic antigen. American Journal of Obstetrics and Gynecology 1984 149 553-559.
121. Riittinen L. Serous ovarian cyst fluids contain high levels of endometrial placental protein 14. Tumor Biology 1992 13 175-179.
122. Mandelin E, Lassus H, Seppälä M, Leminen A, Gustafsson J-Å, Cheng G, Butzow R & Koistinen R. Glycodelin in ovarian serous carcinoma: association with differentiation and survival. Cancer Research 2003 63 6258-6264.
123. Song M, Ramaswamy S, Ramachandran S, Flowers LC, Horowiz IR, Rock JA & Parthasarathy S. Angiogenic role for glycodelin in tumorigenesis. PNAS 2001 98 9265-9270.
124. Jeschke U, Richter DU, Möbius BM, Briese V, Mylonas I & Friese K. Stimulation of progesterone, estradiol and cortisol in trophoblast tumor bewo cells by glycodelin A N-glycans. Anticancer Research 2007 27 2101-2108.