Identification of reaction products between drug substances and excipients by HPLC-SPE-NMR: Ester and amide formation between citric acid and 5-aminosalicylic acid

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 3, 2009, Pages 839-842

  Larsen, Jesper ^a   Staerk, Dan ^a,b   Cornett, Claus ^a   Hansen, Steen H ^a   Jaroszewski, Jerzy W ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

5 Aminosalicylic acid; Citric acid; Drug excipient interactions; HPLC MS; HPLC SPE NMR

Indexed keywords

AMIDE; BUDENOFALK; CITRIC ACID; ENEMA; ESTER DERIVATIVE; EXCIPIENT;

ARTICLE; DRUG FORMULATION; DRUG IMPURITY; DRUG STORAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; SOLID PHASE EXTRACTION;

AMIDES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRIC ACID; ENEMA; ESTERS; EXCIPIENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MESALAMINE; PHARMACEUTICAL PREPARATIONS; PHARMACEUTICAL SOLUTIONS; SOLID PHASE MICROEXTRACTION;

EID: 61449166898     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.12.028     Document Type: Article

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