The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 150, Issue 2, 2009, Pages 202-208

  Wilson, Scott T ^a,b,e   Stanley, Barbara ^a,b,c   Brent, David A ^d   Oquendo, Maria A ^a,b   Huang, Yung Yu ^a,b   Mann, J John ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b College of Physicians and Surgeons ^*  (United States)

^c JOHN JAY COLLEGE OF CRIMINAL JUSTICE   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

A218C; Borderline personality disorder; Impulsiveness; Impulsivity; Suicide; TPH1; Tryptophan hydroxylase

Indexed keywords

TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BORDERLINE STATE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC TRAIT; GENOTYPE; HETEROZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SUICIDAL BEHAVIOR;

ADOLESCENT; ADULT; AGED; ALLELES; BORDERLINE PERSONALITY DISORDER; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOSTILITY; HUMANS; IMPULSIVE BEHAVIOR; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SUICIDE, ATTEMPTED; TRYPTOPHAN HYDROXYLASE; YOUNG ADULT;

EID: 61449143563     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30788     Document Type: Article

References (49)

1. Abbar M, Courtet P, Bellivier F, Leboyer M, Boulenger JP, Castelhau D, Ferreira M, Lambercy C, Mouthon D, Paoloni-Giacobino A, Vessaz M, Malafosse A, Buresi C. 2001. Suicide attempts and the tryptophan hydroxylase gene. Mol Psychiatry 6:268-273.
2. Barratt ES. 1994. Impulsivity: Integrating cognitive, behavioral, biological, and environmental data. In: McCown WB, Johnson JL, Sure MB, editors. The impulsive client: Theory, research, and treatment. Washington: American Psychological Association. pp 39-56.
3. Bellivier F, Chaste P, Malafosse A. 2004. Association between the TPH gene A218C polymorphism and suicidal behavior: A meta-analysis. Am J Med Genet Part B 124B:87-91.
4. Bennett PJ, McMahon WM, Watabe J, Achilles J, Bacon M, Coon H, Grey T, Keller T, Tate D, Tcaciuc I, Workman J, Gray D. 2000. Tryptophan hydroxylase polymorphisms in suicide victims. Psychiatr Genet 10(1):13-17.
5. Black DW, Blum N, Pfohl B, Hale N. 2004. Suicidal behavior in borderline personality disorder: Prevalence, risk factors, prediction, and prevention. J Personal Disord 18:226-239.
6. Bongar B, Peterson LG, Golann S, Hardiman JJ. 1990. Self-mutilation and the chronically suicidal patient: An examination of the frequent visitor to the psychiatric emergency room. Ann Clin Psychiatry 2:217-222.
7. Buss AH, Durkee A. 1957. An inventory for assessing different kinds of hostility. J Consult Clin Psychol 21:343-349.
8. Carver CS, Miller CJ. 2006. Relations of serotonin function to personality: Current views and a key methodological issue. Psychiatry Res 144:1-15.
9. Coccaro EF, Bergman CS, McLean GE. 1993. Heritability of irritable impulsiveness: A study of twins reared together and apart. Psychiatry Res 48:229-242.
10. Cross S, Kim SJ, Weiss LA, Delahanty RJ, Sutcliffe JS, Levanthal BL, Cook EH, Veenstra-VanderWheele J. 2008. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuro-psychopharm 33:353-360.
11. Du L, Faludi G, Palkovitz M, Bakihs D, Hrdina PD. 2000. Tryptophan hydroxylase gene 218 A/C polymorphism is not associated with depressed suicide. Int J Neuropsychopharmacol 3:215-220.
12. Evans J, Reeves B, Platt H, Leibenau A, Goldman D, Jefferson K, Nutt D. 2000. Impulsiveness, serotonin genes, and repetition of deliberate self-harm. Psychol Med 30:1327-1334.
13. First MB, Spitzer RL, Gibbons M, Williams JBW, Benjamin L. 1995. User's Guide for the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). New York: New York State Psychiatry Institute.
14. Gardner AR, Gardner AJ. 1975. Self-mutilation, obsessionality and narcissism. Br J Psychiatry 127:127-132.
15. Hennig J, Reuter M, Netter P, Burk C. 2005. Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism. Behav Neurosci 119:16-25.
16. Henry C, Mitropoulou V, New AS, Koenigsberg HW, Silverman J, Siever LJ. 2001. Affective instability and impulsivity in borderline personality disorder and bipolar II disorders: Similarities and differences. J Psychiatr Res 35(6):307-312.
17. Huang YY, Oquendo MA, Friedman JM, Greenhill LL, Brodsky B, Malone KM, Khait V, Mann JJ. 2003. Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. Neuropsychopharmacol 28:163-169.
18. Kunugi H, Ishida S, Kato T, Sakai T, Tatsumi M, Hirose T, Nanko S. 1999. No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients. Am J Psychiatry 156:774-776.
19. Langbehn DR, Pfohl B. 1993. Clinical correlates ofself-mutilation among psychiatric inpatients. Ann Clin Psychiatry 5:45-51.
20. Malone KM, Corbitt EM, Li S, Mann JJ. 1996. Prolactin response to fenfluramine and suicide attempt lethality in major depression. Br J Psychiatry 168:324-329.
21. Mann JJ, Malone KM. 1997. Cerebrospinal fluid suicide attempts in amines and higher-lethality depressed inpatients. Biol Psychiatry 41:162-171.
22. Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. 1997. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am J Psychiatry 154:1451 -1453.
23. Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. 1999. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 45:603-614.
24. McGlashan TH. 1986. The Chestnut Lodge follow-up study. III. Long-term outcome of borderline personalities. Arch Gen Psychiatry 43:20-30.
25. McGlashan TH, Grilo CM, Sanislow CA, Ralevski E, Morey LC, Gunderson JG, Skodol AE, Shea MT, Zanarini MC, Bender D, Stout RL, Yen S, Pagano M. 2005. Two-year prevalence and stability of individual DSM-IV criteria for schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders: Toward a hybrid model of Axis II disorders. Am J Psychiatry 162:883-889.
26. Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S. 2006. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J Neurosci 26:530-534.
27. New AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ. 1998. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures. Am J Med Genet Part B (Neuropsychiatr Genet) 81:13-17.
28. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. 1994. Suicidality and 5-Hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 51:34-38.
29. Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D. 1997. Sequence, splice site, and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Mol Brain Res 45:145-148.
30. Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M. 1998. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55:593-602.
31. Oldham JM. 2005. Guideline watch: Practice guideline for the treatment of patients with borderline personality disorder. Arlington, VA: American Psychiatric Association.
32. Oquendo MA, Placidi GP, Malone KM, Campbell C, Keilp J, Brodsky B, Kegeles LS, Cooper TB, Parsey RV, van Heertum RL, Mann JJ. 2003. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Arch Gen Psychiatry 60:14-22.
33. Pooly EC, Houston K, Hawton K, Harrison PJ. 2003. Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes. Psychol Med 33:775-783.
34. Preisig M, Ferrero F, Malafosse A. 2005. Monoamine oxidase and trypto-phan hydroxylase gene polymorphisms: Are they associated with bipolar disorder? Am J Pharmacogenomics 5(1):45-52.
35. Reuter M, Hennig J. 2005. Pleiotropic effect of the TPH A218C polymorphism on nicotine dependence and personality. Am J Med Genet Part B 134B:20-24.
36. Rind HB, Russo AF, Whittemore SR. 2000. Developmental regulation of tryptophan hydroxylase messenger RNA expression and enzyme activity in the raphe and its target fields. Neurosci 101:665-677.
37. Sakowski SA, Geddes TJ, Thomas DM, Levi E, Hatfield JS, Kuhn DM. 2006. Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain Res 1085: 11-18.
38. Souery D, Van Gestel S, Massat I, Blairy S, Adolfsson R, Blackwood D, Del-Favero J, Dikeos D, Jakovljevic M, Kaneva R, Lattuada E, Lerer B, Lilli R, Milanova V, Muir W, Nothen M, Oruc L, Papadimitriou G, Propping P, Schulze T, Serretti A, Shapira B, Smeraldi E, Stefanis C, Thomson M, Van Broeckhoven C, Mendlewicz J. 2001. Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: A multicenter association study. Biol Psychiatry 49:405-409.
39. Spitzer RL, Williams JBW, Gibbon M, First MB. 1990. Structured Clinical Interview for the DSM-IIII-R/DSM-IV-Patient Edition. New York: New York State Psychiatric Institute.
40. Stanley B, Wilson ST. 2006. Heightened subjective experience of depression in borderline personality disorder. J Personal Disord 20(4):307-318.
41. Thorisson GA, Smith AV, Krishnan L, Stein LD. 2005. The International HapMap Project Web site. Genome Res 15:1591-1593.
42. Torgersen S. 1984. Genetic and nosological aspects of schizotypal and borderline personality disorders: A twin study. Arch Gen Psychiatry 41:546-554.
43. Torgersen S. 2000. Genetics ofpatients with borderline personality disorder. Psychiatr Clin North Am 23:1-9.
44. Turecki G, Zhu Z, Tzenova J, Lesage A, Seguin M, Tousignant M, Chawky N, Vanier C, Lipp O, Alda M, Joober R, Benkelfat C, Rouleau GA. 2001. TPH and suicidal behavior: A study in suicide completers. Mol Psychiatry 6:98-102.
45. Wilson ST, Stanley BH, Oquendo M, Goldberg P, Zalsman G, Mann JJ. 2007. Comparing impulsivity, hostility, and depression in borderline personality disorder and bipolar II disorder. J Clin Psychiatry 68(10): 1533-1539.
46. Zaboli G, Gizatullin R, Nilsonne A, Wilczek A, Jonsson EG, Ahnemark E, Asberg M, Leopardi R. 2006. Tryptophan hydroxylase I gene variants associate with a group ofsuicidal borderline women. Neuropsychophar-macol 31:1982-1990.
47. Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR. 2006. Prediction of the 10-year course of borderline personality disorder. Am J Psychiatry 163(5):827-832.
48. Zill P, Buttner A, Eisenmenger W, Moller H, Ackenheil M, Bondy B. 2007. Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: A post-mortem study. J Psychiatr Res 41:168-173.
49. Zisook S, Goff A, Sledge P, Shuchter SR. 1994. Reported suicidal behavior and current suicidal ideation in a psychiatric outpatient clinic. Ann Clin Psychiatry 6:27-31.