Circular dichroism spectra and electrophoretic mobility shift assays show that human replication protein A binds and melts intramolecular G-quadruplex structures

Biochemistry

Volumn 48, Issue 5, 2009, Pages 1099-1111

  Fan, Jun Huei ^a   Bochkareva, Elena ^b,c   Bochkarev, Alexey ^b,c,d   Gray, Donald M ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; CIRCULAR DICHROISM SPECTRUM; CIRCULAR DICHROISMS; DNA REPLICATIONS; DNA SECONDARY STRUCTURES; DNA STRUCTURES; ELECTROPHORETIC MOBILITY SHIFT ASSAYS; FORMING SEQUENCES; G-QUADRUPLEX; G-QUADRUPLEX STRUCTURES; G-QUADRUPLEXES; GENOMIC INSTABILITIES; HETEROTRIMER; REPLICATION PROTEIN A; SPECTRAL CHANGES; STABLE COMPLEXES;

ASSAYS; BINDING ENERGY; DICHROISM; DNA; ELECTROPHORETIC MOBILITY; GENES; NUCLEIC ACIDS;

DNA SEQUENCES;

DNA PRIMASE; PYRIMIDINE; REPLICATION FACTOR A; GUANINE QUADRUPLEX;

AMINO ACID SEQUENCE; ARTICLE; CIRCULAR DICHROISM; COMPLEX FORMATION; DNA REPLICATION; GEL MOBILITY SHIFT ASSAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CONFORMATION; GENETICS; HEAT; HUMAN; METABOLISM; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORETIC MOBILITY SHIFT ASSAY; G-QUADRUPLEXES; HOT TEMPERATURE; HUMANS; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STABILITY; REPLICATION PROTEIN A;

EID: 61449133312     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801538h     Document Type: Article

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