Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1789, Issue 3, 2009, Pages 204-211

  Valin, Alvaro ^a,b   Cook, Julie D ^b   Ross, Sarah ^b   Saklad, Christi L ^b   Gill, Grace ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cdk5; E box; GC box; Neuron; p39; Promoter; Sp1; Sp3; Transcription factor

Indexed keywords

BETA ACTIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN DEPENDENT KINASE 5; DNA; LUCIFERASE; PROTEIN P35; PROTEIN P39; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN 3T3; CENTRAL NERVOUS SYSTEM; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; E BOX ELEMENT; ENZYME ACTIVITY; ENZYME SUBUNIT; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NEUROBLASTOMA CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 5; GENE EXPRESSION REGULATION; MICE; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; NEURONS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SEQUENCE HOMOLOGY, NUCLEIC ACID; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 61449113768     PISSN: 18749399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2009.01.007     Document Type: Article

References (42)

1. Ohshima T., Ward J.M., Huh C.G., Longenecker G., Veeranna, Pant H.C., Brady R.O., Martin L.J., and Kulkarni A.B. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 11173-11178
2. Patrick G.N., Zukerberg L., Nikolic M., de la Monte S., Dikkes P., and Tsai L.H. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402 (1999) 615-622
3. Nguyen M.D., Lariviere R.C., and Julien J.P. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30 (2001) 135-147
4. Lew J., Huang Q.Q., Qi Z., Winkfein R.J., Aebersold R., Hunt T., and Wang J.H. A brain-specific activator of cyclin-dependent kinase 5. Nature 371 (1994) 423-426
5. Tsai L.H., Delalle I., Caviness Jr. V.S., Chae T., and Harlow E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371 (1994) 419-423
6. Humbert S., Lanier L.M., and Tsai L.H. Synaptic localization of p39, a neuronal activator of cdk5. Neuroreport 11 (2000) 2213-2216
7. Delalle I., Bhide P.G., Caviness Jr. V.S., and Tsai L.H. Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. J. Neurocytol. 26 (1997) 283-296
8. Cai X.H., Tomizawa K., Tang D., Lu Y.F., Moriwaki A., Tokuda M., Nagahata S., Hatase O., and Matsui H. Changes in the expression of novel Cdk5 activator messenger RNA (p39nck5ai mRNA) during rat brain development. Neurosci. Res. 28 (1997) 355-360
9. Zheng M., Leung C.L., and Liem R.K. Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system. J. Neurobiol. 35 (1998) 141-159
10. Wu D.C., Yu Y.P., Lee N.T., Yu A.C., Wang J.H., and Han Y.F. The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains. Neurochem. Res. 25 (2000) 923-929
11. Ross S., Tienhaara A., Lee M.S., Tsai L.H., and Gill G. GC box-binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35. J. Biol. Chem. 277 (2002) 4455-4464
12. Supp D.M., Witte D.P., Branford W.W., Smith E.P., and Potter S.S. Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev. Biol. 176 (1996) 284-299
13. Billon N., Carlisi D., Datto M.B., van Grunsven L.A., Watt A., Wang X.F., and Rudkin B.B. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Oncogene 18 (1999) 2872-2882
14. Harada T., Morooka T., Ogawa S., and Nishida E. ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat. Cell. Biol. 3 (2001) 453-459
15. Desbarats J., Birge R.B., Mimouni-Rongy M., Weinstein D.E., Palerme J.S., and Newell M.K. Fas engagement induces neurite growth through ERK activation and p35 upregulation. Nat. Cell Biol. 5 (2003) 118-125
16. McEvilly R.J., de Diaz M.O., Schonemann M.D., Hooshmand F., and Rosenfeld M.G. Transcriptional regulation of cortical neuron migration by POU domain factors. Science 295 (2002) 1528-1532
17. Sugitani Y., Nakai S., Minowa O., Nishi M., Jishage K., Kawano H., Mori K., Ogawa M., and Noda T. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes. Dev. 16 (2002) 1760-1765
18. Lewis S.E., and Konradi C. Analysis of DNA-protein interactions in the nervous system using the electrophoretic mobility shift assay. Methods 10 (1996) 301-311
19. Sui G., Soohoo C., Affar el B., Gay F., Shi Y., Forrester W.C., and Shi Y. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 5515-5520
20. Nilden F., Backstrom A., and Bark C. Molecular cloning and characterisation of a mouse gene encoding an isoform of the neuronal cyclin-dependent kinase 5 (CDK5) activator. Biochim. Biophys. Acta 1398 (1998) 371-376
21. Smale S.T., and Kadonaga J.T. The RNA polymerase II core promoter. Annu. Rev. Biochem. 72 (2003) 449-479
22. Smale S.T. Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes. Biochim. Biophys. Acta 1351 (1997) 73-88
23. Boam D.S., Davidson I., and Chambon P. A TATA-less promoter containing binding sites for ubiquitous transcription factors mediates cell type-specific regulation of the gene for transcription enhancer factor-1 (TEF-1). J. Biol. Chem. 270 (1995) 19487-19494
24. Tintrup H., Fischer M., Betz H., and Kuhse J. Exonic Sp1 sites are required for neural-specific expression of the glycine receptor beta subunit gene. Biochem. J. 355 (2001) 179-187
25. McKnight S.L., and Kingsbury R. Transcriptional control signals of a eukaryotic protein-coding gene. Science 217 (1982) 316-324
26. Hagen G., Muller S., Beato M., and Suske G. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res. 20 (1992) 5519-5525
27. Ross S., Best J.L., Zon L.I., and Gill G. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol. Cell. 10 (2002) 831-842
28. Bouwman P., and Philipsen S. Regulation of the activity of Sp1-related transcription factors. Mol. Cell. Endocrinol. 195 (2002) 27-38
29. Hardison R.C. Conserved noncoding sequences are reliable guides to regulatory elements. Trends Genet. 16 (2000) 369-372
30. Sun Y.M., Greenway D.J., Johnson R., Street M., Belyaev N.D., Deuchars J., Bee T., Wilde S., and Buckley N.J. Distinct profiles of REST interactions with its target genes at different stages of neuronal development. Mol. Biol. Cell 16 (2005) 5630-5638
31. Heicklen-Klein A., and Ginzburg I. Tau promoter confers neuronal specificity and binds Sp1 and AP-2. J. Neurochem. 75 (2000) 1408-1418
32. Okamoto S., Sherman K., Bai G., and Lipton S.A. Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation. Brain Res. Mol. Brain Res. 107 (2002) 89-96
33. Black A.R., Jensen D., Lin S.Y., and Azizkhan J.C. Growth/cell cycle regulation of Sp1 phosphorylation. J. Biol. Chem. 274 (1999) 1207-1215
34. Ryu H., Lee J., Olofsson B.A., Mwidau A., Dedeoglu A., Escudero M., Flemington E., Azizkhan-Clifford J., Ferrante R.J., and Ratan R.R. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 4281-4286
35. Ross S.E., Greenberg M.E., and Stiles C.D. Basic helix-loop-helix factors in cortical development. Neuron 39 (2003) 13-25
36. Gray P.A., Fu H., Luo P., Zhao Q., Yu J., Ferrari A., Tenzen T., Yuk D.I., Tsung E.F., Cai Z., Alberta J.A., Cheng L.P., Liu Y., Stenman J.M., Valerius M.T., Billings N., Kim H.A., Greenberg M.E., McMahon A.P., Rowitch D.H., Stiles C.D., and Ma Q. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 306 (2004) 2255-2257
37. Wilson S.W., and Rubenstein J.L. Induction and dorsoventral patterning of the telencephalon. Neuron 28 (2000) 641-651
38. Herdegen T., and Leah J.D. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res. Brain Res. Rev. 28 (1998) 370-490
39. Lonze B.E., and Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 35 (2002) 605-623
40. Biesiada E., Hamamori Y., Kedes L., and Sartorelli V. Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter. Mol. Cell Biol. 19 (1999) 2577-2584
41. Lee L.T., Tan-Un K.C., Pang R.T., Lam D.T., and Chow B.K. Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element. Mol. Endocrinol. 18 (2004) 1740-1755
42. Ray S.K., and Leiter A.B. The basic helix-loop-helix transcription factor NeuroD1 facilitates interaction of Sp1 with the secretin gene enhancer. Mol. Cell Biol. 27 (2007) 7839-7847