1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 2939-2944

  Naganuma, Mitsuki ^a   Nishida, Masayuki ^b   Kuramochi, Kouji ^a   Sugawara, Fumio ^a   Yoshida, Hiromi ^b   Mizushina, Yoshiyuki ^b  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

1 Deoxyrubralactone; DNA polymerase ; DNA polymerase ; Enzyme inhibitor; Families X and Y of DNA polymerases; Polyketide family compound; Talaroflavone

Indexed keywords

1 DEOXYRUBRALACTONE; DEOXYRIBONUCLEASE I; DNA POLYMERASE; DNA PRIMASE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); FLAVONE DERIVATIVE; INOSINATE DEHYDROGENASE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; RNA DIRECTED DNA POLYMERASE; RNA POLYMERASE; TALAROFLAVONE; TELOMERASE; UNCLASSIFIED DRUG;

ALGA; ARTICLE; DNA METABOLISM; EUKARYOTIC CELL; FUNGAL STRAIN; FUNGUS CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; RAT; SPECTROSCOPY;

ALGAE; ANIMALS; DNA POLYMERASE BETA; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; FUNGI; HUMANS; INHIBITORY CONCENTRATION 50; ISOCOUMARINS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ALGAE; BOVINAE; EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS 1; PROKARYOTA; RATTUS;

EID: 40949083456     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.044     Document Type: Article

References (18)

1. DePamphilis M.L. DNA Replication in Eukaryotic Cells (1996), Cold Spring Harbor Laboratory Press p217
2. Seto H., Hatanaka H., Kimura S., Oshige M., Tsuya Y., Mizushina Y., Sawado T., Aoyagi N., Matsumoto T., Hashimoto J., and Sakaguchi K. Biochem. J. 332 (1998) 557
3. Hubscher U., Maga G., and Spadari S. Annu. Rev. Biochem. 71 (2002) 133
4. Bebenek K., and Kunkel T.A. In: Yang W. (Ed). DNA Repair and Replication Advances in Protein Chem Vol. 69 (2004), Elsevier, San Diego p 137
5. Friedberg E.C., Feaver W.J., and Gerlach V.L. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 5681
6. Mizushina Y., Tanaka N., Yagi H., Kurosawa T., Onoue M., Seto H., Horie T., Aoyagi N., Yamaoka M., Matsukage A., Yoshida S., and Sakaguchi K. Biochim. Biophys. Acta 1308 (1996) 256
7. Mizushina Y., Yoshida S., Matsukage A., and Sakaguchi K. Biochim. Biophys. Acta 1336 (1997) 509
8. Mizushina Y., Takahashi N., Ogawa A., Tsurugaya K., Koshino H., Takemura M., Yoshida S., Matsukage A., Sugawara F., and Sakaguchi K. J. Biochem. (Tokyo) 126 (1999) 430
9. Mizushina Y., Ohkubo T., Sugawara F., and Sakaguchi K. Biochemistry 39 (2000) 12606
10. Mizushina Y., Kamisuki S., Mizuno T., Takemura M., Asahara H., Linn S., Yamaguchi T., Matsukage A., Hanaoka F., Yoshida S., Saneyoshi M., Sugawara F., and Sakaguchi K. J. Biol. Chem. 275 (2000) 33957
11. Mizushina Y., Kamisuki S., Kasai N., Shimazaki N., Takemura M., Asahara H., Linn S., Yoshida S., Matsukage A., Koiwai O., Sugawara F., Yoshida H., and Sakaguchi K. J. Biol. Chem. 277 (2002) 630
12. Mizushina Y., Xu X., Asahara H., Takeuchi R., Oshige M., Shimazaki N., Takemura M., Yamaguchi T., Kuroda K., Linn S., Yoshida H., Koiwai O., Saneyoshi M., Sugawara F., and Sakaguchi K. Biochem. J. 370 (2003) 299
13. Kuriyama I., Asano N., Kato I., Ikeda K., Takemura M., Yoshida H., Sakaguchi K., and Mizushina Y. Bioorg. Med. Chem. 13 (2005) 2187
14. Kamisuki S., Ishimaru C., Onoda K., Kuriyama I., Ida N., Sugawara F., Yoshida H., and Mizushina Y. Bioorg. Med. Chem. 15 (2007) 3109
15. Ayer W.A., and Racok J.S. Can. J. Chem. 68 (1990) 2085
16. Kimura Y., Yoshinari T., Koshino H., Fujioka S., Okada K., and Shimada A. Biosci. Biotechnol. Biochem. 71 (2007) 1896
17. Prakash S., Johnson R.E., and Prakash L. Annu. Rev. Biochem. 74 (2005) 317
18. Mizushina Y., Dairaku I., Yanaka N., Takeuchi T., Ishimaru C., Sugawara F., Yoshida H., and Kato N. Biochimie 89 (2007) 581