Hymenoic acid, a novel specific inhibitor of human DNA polymerase λ from a fungus of Hymenochaetaceae sp.

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 5115-5122

  Nishida, Masayuki ^a   Ida, Noriko ^b   Horio, Mao ^b   Takeuchi, Toshifumi ^b   Kamisuki, Shinji ^b   Murata, Hiroshi ^b   Kuramochi, Kouji ^b   Sugawara, Fumio ^b   Yoshida, Hiromi ^a   Mizushina, Yoshiyuki ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

DNA polymerase ; Enzyme inhibitor; Family X of DNA polymerases; Hymenoic acid; Sesquiterpene

Indexed keywords

4 (5' CARBOXY 1' METHYL 1' HEXENYL)CYCLOHEXANECARBOXYLIC ACID; BRCA1 PROTEIN; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE EPSILON; DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE; DNA POLYMERASE LAMBDA; ENZYME INHIBITOR; HYMENOIC ACID; PARATHION; SESQUITERPENE DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA METABOLISM; DNA TEMPLATE; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EUKARYOTE; FUNGUS; HYMENOCHAETACEAE; IN VITRO STUDY; MAMMAL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PROKARYOTE; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; SPECTROSCOPY;

BASIDIOMYCOTA; DNA POLYMERASE BETA; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; SESQUITERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EUKARYOTA; FUNGI; HYMENOCHAETACEAE; MAMMALIA; PROKARYOTA;

EID: 43049095693     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.021     Document Type: Article

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