The matrix effects on kinetic rate constants of antibody-antigen interactions reflect solvent viscosity

Journal of Immunological Methods

Volumn 217, Issue 1-2, 1998, Pages 51-60

  Morgan, Claire L ^a   Newman, David J ^a   M Burrin, Jacky ^a   Price, Christopher P ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

2 microglobulin; Association dissociation rate constants (k(ass), k(diss)); Equilibrium affinity constant (K(A)); IAsys(TM); Matrix effects; Viscosity

Indexed keywords

ANTIBODY; BETA 2 MICROGLOBULIN; BUFFER; DETERGENT; GLYCEROL; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; PHOSPHATE; SODIUM CHLORIDE; SOLVENT;

ANTIBODY AFFINITY; ANTIGEN ANTIBODY REACTION; ARTICLE; BINDING AFFINITY; BIOSENSOR; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; EQUILIBRIUM CONSTANT; HORSE; HUMAN; IMMUNOASSAY; KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; RABBIT; SERUM; VISCOSITY;

ANIMALS; ANTIGEN-ANTIBODY REACTIONS; ARTIFACTS; BETA 2-MICROGLOBULIN; BIOSENSING TECHNIQUES; GLYCEROL; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; KINETICS; MICE; RABBITS; SOLVENTS; VISCOSITY;

EID: 0032144545     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(98)00092-1     Document Type: Article

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