Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice

Hepatology

Volumn 27, Issue 2, 1998, Pages 383-391

  Ghebranious, Nader ^a   Sell, Stewart ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN; PROTEIN P53;

ANIMAL EXPERIMENT; ARTICLE; CANCER RISK; CHEMICAL CARCINOGENESIS; HEPATITIS B; LIVER CARCINOGENESIS; LIVER CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; TRANSGENIC MOUSE;

AFLATOXINS; ANIMALS; CARCINOMA, HEPATOCELLULAR; CHROMOSOME DELETION; DISEASE MODELS, ANIMAL; FEMALE; GENES, P53; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HETEROZYGOTE; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RISK FACTORS; SEX FACTORS;

EID: 0031914318     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270211     Document Type: Article

References (14)

1. Ozturk M. p53 mutation in hepatocellular carcinoma after aflatoxin B1 exposure. Lancet 1991;338:1356-1359.
2. Munoz N, Bosch F: Epidemiology of hepatocellular carcinoma. In: Okuda K, Ishak K, eds. Neoplasms of the Liver. Tokyo: Springer-Verlag, 1987:13-19.
3. Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from Southern Africa. Nature 1991;350:429-431.
4. Yeh FS, Yu MC, Mo CC, Luo S, Tong MJ, Henderson BE. Hepatitis B virus, aflatoxin and hepatocellular carcinoma in Southern Guangxi, China. Cancer Res 1989;49:2506-2509.
5. Van Rensburg SJ, Cook-Mozaffari P, Van Schalkwyk DJ. Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei. Br J Cancer 1985;51:713-726.
6. Yu SZ. Epidemiology of primary liver cancer. In: Tang ZY, ed. Subclinical Hepatocellular Carcinoma. Berlin: Springer-Verlag, 1989:189-212.
7. Agular F, Harris CC, Sun T, Hollstein B, Cerutti P. Geographic variation of p53 mutational profile in non malignant human liver. Science 1994;264:1317-1319.
8. Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan. Lancet 1981;2:1129-1133.
9. Delong S. Drinking water and liver cell cancer. An epidemiologic approach to the etiology of this disease in China. Chinese Medical J 1979;92:748-756.
10. Hollstein M, Sidransky D, Volgestein B, Harris CC. p53 mutations in human cancers. Science 1991;253:49-53.
11. Caron de Fromentel C, Soussi T. The p53 tumor suppressor gene: a model for investigating human mutagenesis. Genes Chromosomomes Cancer 1992;4:1-15.
12. Levine AJ, Momand J, Finlay CA. The p53 tumor suppressor gene. Nature 1991;351:453-456.
13. Weinberg RA. Tumor suppressor genes. Science 1991;254:1138-1146.
14. Eliyahu D, Michalovitz D, Eliyahu S, Pinhasi-Kimhi O, Oren M. Wild-type p53 can inhibit oncogene-mediated focus formation. Proc Natl Acad Sci U S A 1989;86:8763-8767.