2-Azetidinone derivatives: Design, synthesis and evaluation of cholesterol absorption inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1638-1643

  Wang, Yubin ^a   Zhang, Huibin ^a   Huang, Wenlong ^a   Kong, Jing ^a   Zhou, Jinpei ^a   Zhang, Beibei ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Environmental Monitoring Center   (China)

Author keywords

2 Azetidinone derivatives; Amide group; Cholesterol absorption inhibition

Indexed keywords

1 (4 BROMOPHENYL) 3 (3,3 BIS(4 FLUOROPHENYL) 3 HYDROXYPROPYL) 4 (4 METHOXYPHENYL) 2 AZETIDINONE; 1 (4 CHLOROPHENYL) 3 (3 HYDROXY 3,3 DIPHENYLPROPYL) 4 (BENZO[D][1,3]DIOXOL 5 YL) 2 AZETIDINONE; 1 (4 FLUOROPHENYL) 3 (3 HYDROXY 3,3 DIPHENYLPROPYL) 4 (4 METHOXYPHENYL) 2 AZETIDINONE; 1 (4 METHOXYPHENYL) 3 (3,3 BIS(4 FLUOROPHENYL) 3 HYDROXYPROPYL) 4 (6 BROMOBENZO[D][1,3]DIOXOL 5 YL) 2 AZETIDINONE; 1 (6 METHYLPHENYL) 3 (3 HYDROXY 3,3 DIPHENYLPROPYL) 4 (4 METHOXYPHENYL) 2 AZETIDINONE; 1 (6 METHYLPHENYL) 3 (3,3 BIS(4 FLUOROPHENYL) 3 HYDROXYPROPYL) 4 (BENZO[D][1,3]DIOXOL 5 YL) 2 AZETIDINONE; AZETIDINONE DERIVATIVE; CHOLESTEROL; EZETIMIBE; N (4 CHLOROPHENYL) 3 [3 (2 OXO 4 (4 METHOXYPHENYL) 1 (4 METHOXYLPHENYL)AZETIDINYL)]PROPANAMIDE; N (4 CHLOROPHENYL) 3 [3 (2 OXO 4 (4 METHOXYPHENYL) 1 (4 METHYLPHENYL)AZETIDINYL)]PROPANAMIDE; N (4 METHYLPHENYL) 3 [3 (2 OXO 4 (4 METHOXYPHENYL) 1 (4 METHOXYPHENYL)AZETIDINYL)]PROPANAMIDE; N (4 METHYLPHENYL) 3 [3 (2 OXO 4 (4 METHOXYPHENYL) 1 (4 METHYLPHENYL)AZETIDINYL)]PROPANAMIDE; N (4 METHYLPHENYL) 3 [3 (2 OXO 4 (4 METHOXYPHENYL) 1 PHENYLAZETIDINYL)]PROPANAMIDE; N (4 METHYLPHENYL) [3 (2 OXO 4 (4 METHOXYPHENYL) 1 (4 METHOXYPHENYL)AZETIDINYL)]PROPANAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG PURITY; DRUG SYNTHESIS; ENANTIOMER; INHIBITION KINETICS; LIPID ABSORPTION; MALE; NONHUMAN; RAT;

ABSORPTION; ANIMALS; AZETIDINES; CHOLESTEROL; CRICETINAE; DRUG DESIGN; MALE;

EID: 61349183123     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.033     Document Type: Article

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