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Volumn 4, Issue J, 2002, Pages

Pharmacology of ezetimibe

Author keywords

Biliary cholesterol; Cholesterol absorption inhibitor; Cholesterol lowering drugs; Ezetimibe; LDL cholesterol

Indexed keywords

1,4 BIS(4 METHOXYPHENYL) 3 (3 PHENYLPROPYL) 2 AZETIDINONE; ATORVASTATIN; CAMPESTEROL; CHOLESTEROL; DIGOXIN; ETHINYLESTRADIOL; EZETIMIBE; FENOFIBRATE; FLUINDOSTATIN; GEMFIBROZIL; GLIPIZIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEVONORGESTREL; MEVINOLIN; PRAVASTATIN; SIMVASTATIN; SITOSTEROL; WARFARIN;

EID: 0036895375     PISSN: 1520765X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1520-765X(02)90076-3     Document Type: Review
Times cited : (42)

References (25)
  • 2
    • 0030848734 scopus 로고    scopus 로고
    • In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461
    • van Heek M, France CF, Compton DS, et al. In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461. J Pharmacol Exp Ther 1997; 283: 157-63.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 157-163
    • Van Heek, M.1    France, C.F.2    Compton, D.S.3
  • 3
    • 0032510318 scopus 로고    scopus 로고
    • Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)- (4-hydroxyphenyl)-2-azetidinone (SCH 58235): A designed, potent, orally active inhibitor of cholesterol absorption
    • Rosenblum SB, Huynh T, Afonso A, et al. Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)- (4-hydroxyphenyl)-2-azetidinone (SCH 58235): A designed, potent, orally active inhibitor of cholesterol absorption. J Med Chem 1998; 41: 973-80.
    • (1998) J Med Chem , vol.41 , pp. 973-980
    • Rosenblum, S.B.1    Huynh, T.2    Afonso, A.3
  • 4
    • 17944380533 scopus 로고    scopus 로고
    • Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: Pooled analysis of two phase II studies
    • Bays HE, Moore PB, Drehobl MA, et al. Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: Pooled analysis of two phase II studies. Clin Ther 2001; 23: 1209-30.
    • (2001) Clin Ther , vol.23 , pp. 1209-1230
    • Bays, H.E.1    Moore, P.B.2    Drehobl, M.A.3
  • 5
    • 0034776367 scopus 로고    scopus 로고
    • Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function
    • van Heek M, Farley C, Compton DS, Hoos L, Davis HR. Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. Br J Pharmacol 2001; 134: 409-17.
    • (2001) Br J Pharmacol , vol.134 , pp. 409-417
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3    Hoos, L.4    Davis, H.R.5
  • 6
    • 0035572836 scopus 로고    scopus 로고
    • Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in apoE knockout mice
    • Davis HR Jr, Compton DS, Hoos L, Tetzloff G. Ezetimibe, a potent cholesterol absorption inhibitor, inhibits the development of atherosclerosis in apoE knockout mice. Arterioscler Thromb Vasc Biol 2001; 21: 2032-8.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 2032-2038
    • Davis H.R., Jr.1    Compton, D.S.2    Hoos, L.3    Tetzloff, G.4
  • 7
    • 0037196569 scopus 로고    scopus 로고
    • The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption
    • Altmann SW, Davis HR Jr, et al. The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption. Biochim Biophys Acta 2002; 30: 77-93.
    • (2002) Biochim Biophys Acta , vol.30 , pp. 77-93
    • Altmann, S.W.1    Davis H.R., Jr.2
  • 8
    • 0034991315 scopus 로고    scopus 로고
    • Ezetimibe, a potent cholesterol absorption inhibitor, normalizes combined dyslipidemia in obese hyperinsulinemic hamsters
    • van Heek M, Austin TM, Farley C, Cook JA, Tetzloff GG, Davis HR. Ezetimibe, a potent cholesterol absorption inhibitor, normalizes combined dyslipidemia in obese hyperinsulinemic hamsters. Diabetes 2001; 50: 1330-5.
    • (2001) Diabetes , vol.50 , pp. 1330-1335
    • Van Heek, M.1    Austin, T.M.2    Farley, C.3    Cook, J.A.4    Tetzloff, G.G.5    Davis, H.R.6
  • 9
    • 0035831089 scopus 로고    scopus 로고
    • The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys
    • van Heek M, Compton DS, Davis HR. The cholesterol absorption inhibitor, ezetimibe, decreases diet-induced hypercholesterolemia in monkeys. Eur J Pharmacol 2001; 415: 79-84.
    • (2001) Eur J Pharmacol , vol.415 , pp. 79-84
    • Van Heek, M.1    Compton, D.S.2    Davis, H.R.3
  • 10
    • 0034765624 scopus 로고    scopus 로고
    • The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs
    • Davis HR Jr, Pula KK, Alton KB, Burrier RE, Watkins RW. The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs. Metabolism 2001; 50: 1234-41.
    • (2001) Metabolism , vol.50 , pp. 1234-1241
    • Davis H.R., Jr.1    Pula, K.K.2    Alton, K.B.3    Burrier, R.E.4    Watkins, R.W.5
  • 12
    • 0002038139 scopus 로고    scopus 로고
    • Effect of ezetimibe on serum concentrations of lipid-soluble vitamins
    • Knopp R, Bays H, Manion C. Effect of ezetimibe on serum concentrations of lipid-soluble vitamins. Atherosclerosis Supplements 2001; 2: 90.
    • (2001) Atherosclerosis Supplements , vol.2 , pp. 90
    • Knopp, R.1    Bays, H.2    Manion, C.3
  • 13
    • 0034003105 scopus 로고    scopus 로고
    • Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663
    • van Heek M, Farley C, Compton DS, et al. Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663. Br J Pharmacol 2000; 129: 1748-54.
    • (2000) Br J Pharmacol , vol.129 , pp. 1748-1754
    • Van Heek, M.1    Farley, C.2    Compton, D.S.3
  • 14
    • 18344380806 scopus 로고    scopus 로고
    • Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects
    • Patrick JE, Kosoglou T, Stauber KL, et al. Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects. Drug Metab Dispos 2002; 30: 430-7.
    • (2002) Drug Metab Dispos , vol.30 , pp. 430-437
    • Patrick, J.E.1    Kosoglou, T.2    Stauber, K.L.3
  • 15
    • 0002075919 scopus 로고    scopus 로고
    • Ezetimibe does not affect the pharmacokinetics of oral contraceptives
    • Keung A, Kosoglou T, Statkevich P. Ezetimibe does not affect the pharmacokinetics of oral contraceptives. Clin Pharmacol Ther 2001; 69: 55.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 55
    • Keung, A.1    Kosoglou, T.2    Statkevich, P.3
  • 16
    • 0002075921 scopus 로고    scopus 로고
    • Ezetimibe does not affect the pharmacokinetics or pharmacodynamics of warfarin
    • Bauer K, Kosoglou T, Statkevich P. Ezetimibe does not affect the pharmacokinetics or pharmacodynamics of warfarin. Clin Pharmacol Ther 2001; 69: 5.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 5
    • Bauer, K.1    Kosoglou, T.2    Statkevich, P.3
  • 17
    • 0003313921 scopus 로고    scopus 로고
    • Ezetimibe does not affect the pharmacokinetics and pharmacodynamics of digoxin
    • Kosoglou T, Statkevich P, Bauer K, et al. Ezetimibe does not affect the pharmacokinetics and pharmacodynamics of digoxin. AAPS PharmSci 2001 Annual Meeting Supplement 2001:3(3). Available from http://www.aapspharmaceutica.com/search/abstract.view.asp?id=290.
    • (2001) AAPS PharmSci 2001 Annual Meeting Supplement , vol.3 , Issue.3
    • Kosoglou, T.1    Statkevich, P.2    Bauer, K.3
  • 18
    • 0002135761 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between ezetimibe and fenofibrate
    • Reyderman L, Kosoglou T, Maxwell S. Lack of pharmacokinetic interaction between ezetimibe and fenofibrate. AAPS PharmSci 2001 Annual Meeting Supplement 2001:3(3). Available from http://www.aapspharmaceutica.com/search/abstract.view.asp?id=366.
    • (2001) AAPS PharmSci 2001 Annual Meeting Supplement , vol.3 , Issue.3
    • Reyderman, L.1    Kosoglou, T.2    Maxwell, S.3
  • 20
    • 0001965489 scopus 로고    scopus 로고
    • No pharmacokinetic drug interaction between ezetimibe and lovastatin
    • Reyderman L, Kosoglou T, Statkevich P. No pharmacokinetic drug interaction between ezetimibe and lovastatin. Clin Pharmacol Ther 2001; 69: 67.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 67
    • Reyderman, L.1    Kosoglou, T.2    Statkevich, P.3
  • 21
    • 0011810647 scopus 로고    scopus 로고
    • No pharmacokinetic interaction between ezetimibe and either cerivastatin or fluvastatin
    • Reyderman L, Statkevich P, Kosoglou T. No pharmacokinetic interaction between ezetimibe and either cerivastatin or fluvastatin. AAPS PharmSci 2001 Annual Meeting Supplement 2001:3(3). Available from http://www.aapspharmaceutica.com/search/abstract.view.asp?id=371.
    • (2001) AAPS PharmSci 2001 Annual Meeting Supplement , vol.3 , Issue.3
    • Reyderman, L.1    Statkevich, P.2    Kosoglou, T.3
  • 22
    • 0002075922 scopus 로고    scopus 로고
    • Ezetimibe does not affect the pharmacokinetics and pharmacodynamics of glipizide
    • Statkevich P, Reyderman L, Kosoglou T. Ezetimibe does not affect the pharmacokinetics and pharmacodynamics of glipizide. Clin Pharmacol Ther 2001; 69: 68.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 68
    • Statkevich, P.1    Reyderman, L.2    Kosoglou, T.3
  • 23
    • 0002763570 scopus 로고    scopus 로고
    • Lack of a pharmacokinetic interaction between ezetimibe and atorvastatin
    • Zhu Y, Statkevich P, Kosoglou T. Lack of a pharmacokinetic interaction between ezetimibe and atorvastatin. Clin Pharmacol Ther 2001; 69: 68.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 68
    • Zhu, Y.1    Statkevich, P.2    Kosoglou, T.3
  • 24
    • 18544390238 scopus 로고    scopus 로고
    • Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor, ezetimibe, and simvastatin
    • Kosoglou T, Meyer I, Veltri E et al. Pharmacodynamic interaction between the new selective cholesterol absorption inhibitor, ezetimibe, and simvastatin. Br J Clin Pharmacol 2002; 54: 309-319.
    • (2002) Br J Clin Pharmacol , vol.54 , pp. 309-319
    • Kosoglou, T.1    Meyer, I.2    Veltri, E.3
  • 25
    • 0037044454 scopus 로고    scopus 로고
    • Inhibition of intestinal cholesterol absorption by ezetimibe in humans
    • Sudhop T, Lutjohann D, Kodal A, et al. Inhibition of intestinal cholesterol absorption by ezetimibe in humans. Circulation 2002; 106: 1943-1948.
    • (2002) Circulation , vol.106 , pp. 1943-1948
    • Sudhop, T.1    Lutjohann, D.2    Kodal, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.