Design, synthesis, and anti-tumor evaluation of novel symmetrical bis-benzimidazoles

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1808-1812

  Yang, Yan Hui ^a   Cheng, Mao Sheng ^a   Wang, Qing He ^a   Nie, Han ^a   Liao, Na ^a   Wang, Jian ^a   Chen, Hong ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Anti tumor; Minor groove binder; Molecular modeling; Symmetrical bis benzimidazole

Indexed keywords

2,2' DI [(6 CHLORO PRID 3 YL)METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [(PRID 2 YL)METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [(PRID 3 YL)METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [(PRID 4 YL)METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [[(3 METHOXY 4 CHLORO)PRID 2 YL]METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [[(3 METHYL 4 ETHOXY)PRID 2 YL]METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [[(3 METHYL 4 METHOXY)PRID 2 YL]METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [[(3,4 DIMETHOXY)PRID 2 YL]METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [[(3,5 DIMETHYL 4 METHOXY)PRID 2 YL]METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; 2,2' DI [[[3, METHYL 4 (2,2,2 TRIFLUOROETHYL)]PRID 2 YL]METHYLENETHIO] 5,5' BIS 1H,1'H BENZIMIDAZOLE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BISBENZIMIDAZOLE; CELL LINE, TUMOR; DNA; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NEOPLASMS; NUCLEIC ACID CONFORMATION;

EID: 61349177912     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.07.021     Document Type: Article

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