An in vivo microdialysis measurement of harpagoside in rat blood and bile for predicting hepatobiliary excretion and its interaction with cyclosporin A and verapamil

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 8-9, 2009, Pages 751-756

  Wu, Qian ^a   Wen, Xiao Dong ^a   Qi, Lian Wen ^a   Wang, Wei ^a   Yi, Ling ^a   Bi, Zhi Ming ^a   Li, Ping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cyclosporin A; Harpagoside; Hepatobiliary excretion; In vivo microdialysis; P glucoprotein; Pharmacokinetic; Verapamil

Indexed keywords

CYCLOSPORIN A; HARPAGOSIDE; HEPATOBILIARY EXCRETION; IN VIVO MICRODIALYSIS; P-GLUCOPROTEIN; VERAPAMIL;

BLOOD; CHROMATOGRAPHIC ANALYSIS; DIALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHARMACOKINETICS;

DRUG PRODUCTS;

CYCLOSPORIN A; GLYCOPROTEIN P; HARPAGOSIDE; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MICRODIALYSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCROPHULARIACEAE;

ANIMALS; BILE; CYCLOSPORINE; DRUG INTERACTIONS; GLYCOSIDES; MICRODIALYSIS; PLANT EXTRACTS; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; SCROPHULARIA; VERAPAMIL;

RATTUS; SCROPHULARIA;

EID: 61349170275     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.02.001     Document Type: Article

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