Simultaneous determination of harpagoside and cinnamic acid in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies

Biomedical Chromatography

Volumn 22, Issue 1, 2008, Pages 50-57

  Wang, Su Jun ^a   Ruan, Jin Xiu ^a   Zhao, Yan Hong ^a   Zhang, Zhen Qing ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

Cinnamic acid; Harpagoside; LC MS; Pharmacokinetics; Radix Scrophulariae

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; NEGATIVE IONS; PHARMACOKINETICS; RATS;

ANALYTES; CINNAMIC ACIDS; HARPAGOSIDE; LC/MS; LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-MASS SPECTROMETRIES; PHARMACOKINETIC STUDIES; RADIX SCROPHULARIA; RAT PLASMA; SAMPLE PREPARATION; SIMULTANEOUS DETERMINATIONS;

ACETONITRILE;

ACETONITRILE; AMMONIUM FORMATE; CINNAMIC ACID; HARPAGOSIDE; PLANT EXTRACT; SCROPHULARIA NINGPOENSIS EXTRACT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; RAT; SCROPHULARIA NINGPOENSIS; SCROPHULARIACEAE; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

RATTUS;

EID: 38749103073     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.895     Document Type: Article

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