4,4-Difluorinated analogues of l-arginine and NG-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1758-1762

  Martin, Nathaniel I ^a   Woodward, Joshua J ^b   Winter, Michael B ^b   Marletta, Michael A ^b,c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Fluorinated substrate analogues; Mechanistic probes; Nitric oxide synthase

Indexed keywords

4,4 DIFLUORO N G HYDROXY ARGININE; 4,4 DIFLUOROARGININE; ARGININE; ARGININE DERIVATIVE; FERRIC ION; HEME; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; CHEMICAL STRUCTURE; CONTROLLED STUDY; FLUORINATION; OXIDATION; OXIDATION KINETICS; TITRIMETRY;

ARGININE; CATALYSIS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; FLUORINE; HEME; MODELS, CHEMICAL; NITRIC OXIDE SYNTHASE; OXYGEN; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 61349118825     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.076     Document Type: Article

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