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Volumn 113, Issue 3-5, 2009, Pages 281-289

Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: Estrogen receptor dependent or independent pathways of raloxifene

Author keywords

Estrogen; Osteoblasts; Osteoporosis; SERM

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; GROWTH ARREST SPECIFIC PROTEIN 6; RALOXIFENE; TAMOXIFEN; TRANSCRIPTION FACTOR MAF;

EID: 61349111321     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.01.010     Document Type: Article
Times cited : (27)

References (47)
  • 1
    • 0031955217 scopus 로고    scopus 로고
    • A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men
    • Riggs B.L., Khosla S., and Melton III L.J. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J. Bone Miner. Res. 13 (1998) 763-773
    • (1998) J. Bone Miner. Res. , vol.13 , pp. 763-773
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 2
    • 0023930991 scopus 로고
    • Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats
    • Turner R.T., Wakley G.K., Hannon K.S., and Bell N.H. Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats. Endocrinology 122 (1988) 1146-1150
    • (1988) Endocrinology , vol.122 , pp. 1146-1150
    • Turner, R.T.1    Wakley, G.K.2    Hannon, K.S.3    Bell, N.H.4
  • 3
    • 0025230416 scopus 로고
    • Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats
    • Takano-Yamamoto T., and Rodan G.A. Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 2172-2176
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 2172-2176
    • Takano-Yamamoto, T.1    Rodan, G.A.2
  • 4
    • 0031978099 scopus 로고    scopus 로고
    • Detection of estrogen receptor alpha, carbonic anhydrase II and tartrate-resistant acid phosphatase mRNAs in putative mononuclear osteoclast precursor cells of neonatal rats by fluorescence in situ hybridization
    • Huang W.H., Lau A.T., Daniels L.L., Fujii H., Seydel U., Wood D.J., Papadimitriou J.M., and Zheng M.H. Detection of estrogen receptor alpha, carbonic anhydrase II and tartrate-resistant acid phosphatase mRNAs in putative mononuclear osteoclast precursor cells of neonatal rats by fluorescence in situ hybridization. J. Mol. Endocrinol. 20 (1998) 211-219
    • (1998) J. Mol. Endocrinol. , vol.20 , pp. 211-219
    • Huang, W.H.1    Lau, A.T.2    Daniels, L.L.3    Fujii, H.4    Seydel, U.5    Wood, D.J.6    Papadimitriou, J.M.7    Zheng, M.H.8
  • 6
    • 0033028733 scopus 로고    scopus 로고
    • Expression and localization of estrogen receptor-beta in murine and human bone
    • Vidal O., Kindblom L.G., and Ohlsson C. Expression and localization of estrogen receptor-beta in murine and human bone. J. Bone Miner. Res. 14 (1999) 923-929
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 923-929
    • Vidal, O.1    Kindblom, L.G.2    Ohlsson, C.3
  • 7
    • 0035010706 scopus 로고    scopus 로고
    • Estrogen receptors alpha and beta are differentially expressed in developing human bone
    • Bord S., Horner A., Beavan S., and Compston J. Estrogen receptors alpha and beta are differentially expressed in developing human bone. J. Clin. Endocrinol. Metab. 86 (2001) 2309-2314
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 2309-2314
    • Bord, S.1    Horner, A.2    Beavan, S.3    Compston, J.4
  • 8
    • 0033963919 scopus 로고    scopus 로고
    • Steroid hormone receptor expression and action in bone
    • Bland R. Steroid hormone receptor expression and action in bone. Clin. Sci. (Lond). 98 (2000) 217-240
    • (2000) Clin. Sci. (Lond). , vol.98 , pp. 217-240
    • Bland, R.1
  • 11
    • 0031058448 scopus 로고    scopus 로고
    • Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women
    • Beresford S.A., Weiss N.S., Voigt L.F., and McKnight B. Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet 349 (1997) 458-461
    • (1997) Lancet , vol.349 , pp. 458-461
    • Beresford, S.A.1    Weiss, N.S.2    Voigt, L.F.3    McKnight, B.4
  • 12
    • 0028322946 scopus 로고
    • Dual-energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats
    • Sato M., McClintock C., Kim J., Turner C.H., Bryant H.U., Magee D., and Slemenda C.W. Dual-energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats. J. Bone Miner. Res. 9 (1994) 715-724
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 715-724
    • Sato, M.1    McClintock, C.2    Kim, J.3    Turner, C.H.4    Bryant, H.U.5    Magee, D.6    Slemenda, C.W.7
  • 13
    • 0030664688 scopus 로고    scopus 로고
    • Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women
    • Delmas P.D., Bjarnason N.H., Mitlak B.H., Ravoux A.C., Shah A.S., Huster W.J., Draper M., and Christiansen C. Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N. Engl. J. Med. 337 (1997) 1641-1647
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1641-1647
    • Delmas, P.D.1    Bjarnason, N.H.2    Mitlak, B.H.3    Ravoux, A.C.4    Shah, A.S.5    Huster, W.J.6    Draper, M.7    Christiansen, C.8
  • 17
    • 0029792521 scopus 로고    scopus 로고
    • Stimulation of creatine kinase specific activity in human osteoblast and endometrial cells by estrogens and anti-estrogens and its modulation by calciotropic hormones
    • Fournier B., Haring S., Kaye A.M., and Somjen D. Stimulation of creatine kinase specific activity in human osteoblast and endometrial cells by estrogens and anti-estrogens and its modulation by calciotropic hormones. J. Endocrinol. 150 (1996) 275-285
    • (1996) J. Endocrinol. , vol.150 , pp. 275-285
    • Fournier, B.1    Haring, S.2    Kaye, A.M.3    Somjen, D.4
  • 18
    • 0344142469 scopus 로고    scopus 로고
    • Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture
    • Qu Q., Harkonen P.L., and Vaananen H.K. Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture. J. Cell Biochem. 73 (1999) 500-507
    • (1999) J. Cell Biochem. , vol.73 , pp. 500-507
    • Qu, Q.1    Harkonen, P.L.2    Vaananen, H.K.3
  • 20
    • 0017372823 scopus 로고
    • Effects of tamoxifen in relation to breast cancer
    • Jordan V.C. Effects of tamoxifen in relation to breast cancer. Br. Med. J. 1 (1977) 1534-1535
    • (1977) Br. Med. J. , vol.1 , pp. 1534-1535
    • Jordan, V.C.1
  • 22
    • 0035686742 scopus 로고    scopus 로고
    • Raloxifene: risks and benefits
    • Barrett-Connor E. Raloxifene: risks and benefits. Ann. N.Y. Acad. Sci. 949 (2001) 295-303
    • (2001) Ann. N.Y. Acad. Sci. , vol.949 , pp. 295-303
    • Barrett-Connor, E.1
  • 23
    • 1542344018 scopus 로고    scopus 로고
    • Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta
    • Kian T.M., Rogatsky I., Tzagarakis-Foster C., Cvoro A., An J., Christy R.J., Yamamoto K.R., and Leitman D.C. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol. Biol. Cell 15 (2004) 1262-1272
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1262-1272
    • Kian, T.M.1    Rogatsky, I.2    Tzagarakis-Foster, C.3    Cvoro, A.4    An, J.5    Christy, R.J.6    Yamamoto, K.R.7    Leitman, D.C.8
  • 24
    • 0028947930 scopus 로고
    • Development and characterization of a conditionally immortalized human fetal osteoblastic cell line
    • Harris S.A., Enger R.J., Riggs B.L., and Spelsberg T.C. Development and characterization of a conditionally immortalized human fetal osteoblastic cell line. J. Bone Miner. Res. 10 (1995) 178-186
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 178-186
    • Harris, S.A.1    Enger, R.J.2    Riggs, B.L.3    Spelsberg, T.C.4
  • 25
    • 33847765402 scopus 로고    scopus 로고
    • Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane
    • Miki Y., Suzuki T., Hatori M., Igarashi K., Aisaki K., Kanno J., Nakamura Y., Uzuki M., Sawai T., and Sasano H. Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone 40 (2007) 876-887
    • (2007) Bone , vol.40 , pp. 876-887
    • Miki, Y.1    Suzuki, T.2    Hatori, M.3    Igarashi, K.4    Aisaki, K.5    Kanno, J.6    Nakamura, Y.7    Uzuki, M.8    Sawai, T.9    Sasano, H.10
  • 26
    • 17644407354 scopus 로고    scopus 로고
    • Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mülerian duct cells using microarray
    • Miki Y., Suzuki T., Tazawa C., Ishizuka M., Semba S., Gorai I., and Sasano H. Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mülerian duct cells using microarray. Cancer Lett. 220 (2005) 197-210
    • (2005) Cancer Lett. , vol.220 , pp. 197-210
    • Miki, Y.1    Suzuki, T.2    Tazawa, C.3    Ishizuka, M.4    Semba, S.5    Gorai, I.6    Sasano, H.7
  • 28
    • 0035950447 scopus 로고    scopus 로고
    • Regulation of human cbfa1 gene transcription in osteoblasts by selective estrogen receptor modulators (SERMs)
    • Tou L., Quibria N., and Alexander J.M. Regulation of human cbfa1 gene transcription in osteoblasts by selective estrogen receptor modulators (SERMs). Mol. Cell Endocrinol. 183 (2001) 71-79
    • (2001) Mol. Cell Endocrinol. , vol.183 , pp. 71-79
    • Tou, L.1    Quibria, N.2    Alexander, J.M.3
  • 29
    • 12844262221 scopus 로고    scopus 로고
    • Cell- and ligand-specific regulation of promoters containing activator protein-1 and Sp1 sites by estrogen receptors alpha and beta
    • Schultz J.R., Petz L.N., and Nardulli A.M. Cell- and ligand-specific regulation of promoters containing activator protein-1 and Sp1 sites by estrogen receptors alpha and beta. J. Biol. Chem. 280 (2005) 347-354
    • (2005) J. Biol. Chem. , vol.280 , pp. 347-354
    • Schultz, J.R.1    Petz, L.N.2    Nardulli, A.M.3
  • 30
    • 0038377650 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-beta oestradiol and raloxifene
    • Cheung J., Mak Y.T., Papaioannou S., Evans B.A., Fogelman I., and Hampson G. Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-beta oestradiol and raloxifene. J. Endocrinol. 177 (2003) 423-433
    • (2003) J. Endocrinol. , vol.177 , pp. 423-433
    • Cheung, J.1    Mak, Y.T.2    Papaioannou, S.3    Evans, B.A.4    Fogelman, I.5    Hampson, G.6
  • 31
    • 12344314494 scopus 로고    scopus 로고
    • Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures
    • Mendez-Davila C., Garcia-Moreno C., Turbi C., and de la Piedra C. Effects of 17beta-estradiol, tamoxifen and raloxifene on the protein and mRNA expression of interleukin-6, transforming growth factor-beta1 and insulin-like growth factor-1 in primary human osteoblast cultures. J. Endocrinol. Invest. 27 (2004) 904-912
    • (2004) J. Endocrinol. Invest. , vol.27 , pp. 904-912
    • Mendez-Davila, C.1    Garcia-Moreno, C.2    Turbi, C.3    de la Piedra, C.4
  • 32
    • 0037111372 scopus 로고    scopus 로고
    • Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma
    • Cao S., Liu J., Chesi M., Bergsagel P.L., Ho I.C., Donnelly R.P., and Ma X. Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. J. Immunol. 169 (2002) 5715-5725
    • (2002) J. Immunol. , vol.169 , pp. 5715-5725
    • Cao, S.1    Liu, J.2    Chesi, M.3    Bergsagel, P.L.4    Ho, I.C.5    Donnelly, R.P.6    Ma, X.7
  • 33
    • 0012611313 scopus 로고    scopus 로고
    • Pathophysiology of osteoporosis (chapter 73)
    • Bilezikian J.P., Raisz L.G., and Rodan A. (Eds), Academic Press, A Division of Harcourt, Inc., NY, USA
    • Rodan G.A., Raisz L.G., and Bilezikian J.P. Pathophysiology of osteoporosis (chapter 73). In: Bilezikian J.P., Raisz L.G., and Rodan A. (Eds). Principles of Bone Biology. 2nd ed. vol. 1 (2002), Academic Press, A Division of Harcourt, Inc., NY, USA 1275-1290
    • (2002) Principles of Bone Biology. 2nd ed. , vol.1 , pp. 1275-1290
    • Rodan, G.A.1    Raisz, L.G.2    Bilezikian, J.P.3
  • 34
    • 0141829763 scopus 로고    scopus 로고
    • Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development
    • MacLean H.E., Kim J.I., Glimcher M.J., Wang J., Kronenberg H.M., and Glimcher L.H. Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development. Dev. Biol. 262 (2003) 51-63
    • (2003) Dev. Biol. , vol.262 , pp. 51-63
    • MacLean, H.E.1    Kim, J.I.2    Glimcher, M.J.3    Wang, J.4    Kronenberg, H.M.5    Glimcher, L.H.6
  • 35
    • 1442285916 scopus 로고    scopus 로고
    • c-maf in multiple myeloma: an oncogene enhancing tumor-stroma interactions
    • Kienast J., and Berdel W.E. c-maf in multiple myeloma: an oncogene enhancing tumor-stroma interactions. Cancer Cell 5 (2004) 109-110
    • (2004) Cancer Cell , vol.5 , pp. 109-110
    • Kienast, J.1    Berdel, W.E.2
  • 36
    • 20444419447 scopus 로고    scopus 로고
    • Osteoclastic bone resorption through receptor tyrosine kinase and extracellular signal-regulated kinase signaling in mature osteoclasts
    • Kawaguchi H., Katagiri M., and Chikazu D. Osteoclastic bone resorption through receptor tyrosine kinase and extracellular signal-regulated kinase signaling in mature osteoclasts. Mod. Rheumatol. 14 (2004) 1-5
    • (2004) Mod. Rheumatol. , vol.14 , pp. 1-5
    • Kawaguchi, H.1    Katagiri, M.2    Chikazu, D.3
  • 37
    • 0030062954 scopus 로고    scopus 로고
    • Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts
    • Goruppi S., Ruaro E., and Schneider C. Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts. Oncogene 12 (1996) 471-480
    • (1996) Oncogene , vol.12 , pp. 471-480
    • Goruppi, S.1    Ruaro, E.2    Schneider, C.3
  • 40
    • 0037151101 scopus 로고    scopus 로고
    • Transcriptional effects of chronic Akt activation in the heart
    • Cook S.A., Matsui T., Li L., and Rosenzweig A. Transcriptional effects of chronic Akt activation in the heart. J. Biol. Chem. 277 (2002) 22528-22533
    • (2002) J. Biol. Chem. , vol.277 , pp. 22528-22533
    • Cook, S.A.1    Matsui, T.2    Li, L.3    Rosenzweig, A.4
  • 41
    • 0035968133 scopus 로고    scopus 로고
    • Decreased expression of the NADH:ubiquinone oxidoreductase (complex I) subunit 4 in 1-methyl-4-phenylpyridinium-treated human neuroblastoma SH-SY5Y cells
    • Conn K.J., Ullman M.D., Eisenhauer P.B., Fine R.E., and Wells J.M. Decreased expression of the NADH:ubiquinone oxidoreductase (complex I) subunit 4 in 1-methyl-4-phenylpyridinium-treated human neuroblastoma SH-SY5Y cells. Neurosci. Lett. 306 (2001) 145-148
    • (2001) Neurosci. Lett. , vol.306 , pp. 145-148
    • Conn, K.J.1    Ullman, M.D.2    Eisenhauer, P.B.3    Fine, R.E.4    Wells, J.M.5
  • 42
    • 0034807672 scopus 로고    scopus 로고
    • Cardiovascular protective effects of 17beta-estradiol metabolites
    • Dubey R.K., and Jackson E.K. Cardiovascular protective effects of 17beta-estradiol metabolites. J. Appl. Physiol. 91 (2001) 1868-1883
    • (2001) J. Appl. Physiol. , vol.91 , pp. 1868-1883
    • Dubey, R.K.1    Jackson, E.K.2
  • 44
    • 0036239630 scopus 로고    scopus 로고
    • Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen
    • Desai P.B., Nallani S.C., Sane R.S., Moore L.B., Goodwin B.J., Buckley D.J., and Buckley A.R. Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen. Drug Metab. Dispos. 30 (2002) 608-612
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 608-612
    • Desai, P.B.1    Nallani, S.C.2    Sane, R.S.3    Moore, L.B.4    Goodwin, B.J.5    Buckley, D.J.6    Buckley, A.R.7
  • 45
    • 33745210139 scopus 로고    scopus 로고
    • Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells
    • Ichikawa T., Horie-Inoue K., Ikeda K., Blumberg B., and Inoue S. Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. J. Biol. Chem. 281 (2006) 16927-16934
    • (2006) J. Biol. Chem. , vol.281 , pp. 16927-16934
    • Ichikawa, T.1    Horie-Inoue, K.2    Ikeda, K.3    Blumberg, B.4    Inoue, S.5
  • 46
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • Manolagas S.C. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21 (2000) 115-137
    • (2000) Endocr. Rev. , vol.21 , pp. 115-137
    • Manolagas, S.C.1
  • 47
    • 34249690772 scopus 로고    scopus 로고
    • Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro
    • Michael H., Harkonen P.L., Kangas L., Vaananen H.K., and Hentunen T.A. Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro. Br. J. Pharmacol. 151 (2007) 384-395
    • (2007) Br. J. Pharmacol. , vol.151 , pp. 384-395
    • Michael, H.1    Harkonen, P.L.2    Kangas, L.3    Vaananen, H.K.4    Hentunen, T.A.5


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