Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture

Journal of Cellular Biochemistry

Volumn 73, Issue 4, 1999, Pages 500-507

  Qu, Qiang ^a,b   Härkönen, Pirkko L ^a   Väänänen, H Kalervo ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Estrogen; FC1271a; Osteoblast; Raloxifene; Tamoxifen

Indexed keywords

1,1,2 TRIPHENYLETHYLENE DERIVATIVE; ALKALINE PHOSPHATASE; ANTIESTROGEN; CALCIUM; CARBON 14; COLLAGEN TYPE 1; ESTRADIOL; ESTROGEN; FULVESTRANT; MATRIX PROTEIN; PROLINE; RALOXIFENE; TAMOXIFEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE MARROW CULTURE; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANIMALS; BONE MARROW CELLS; BONE MATRIX; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; FEMALE; MICE; OSTEOBLASTS;

ANIMALIA;

EID: 0344142469     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19990615)73:4<500::AID-JCB8>3.0.CO;2-E     Document Type: Article

References (40)

1. Arts J, Kuiper GGJM, Janssen JMMF, Gustafsson J-Å, Löwik CWGM, Pols HAP, van Leeuwen JPTM. 1997. Differential expression of estrogen receptors α and β mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138:5067-5070.
2. Chow JWM, Lean JM, Chambers TJ. 1992a. 17β-Estradiol stimulates cancellous bone formation in female rats. Endocrinology 130:3025-3032.
3. Chow J, Tobias JH, Colston KW, Chambers TJ, 1992b. Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation. J Clin Invest 89:74-78.
4. Chow JWM, Lean JM, Chambers TJ. 1992c. 17β-estradiol stimulates cancellous bone formation in female rats. Endocrinology 130:3025-3032.
5. Eriksen EF, Colvard DS, Berg NG, Graham ML, Mann DG, Spelsberg TC, Riggs BL. 1988. Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241: 84-86.
6. Ernst M, Schmid CH, Froesch ER. 1988. Enhanced osteoblast proliferation and collagen gene expression by estradiol. Proc Natl Acad Sci USA 85:2307-2310.
7. Evans GL, Bryant HU, Magee D, Sato M, Turner RT. 1994. The effects of raloxifene on tibia histomorphometry in ovariectomized rats. Endocrinology 134:2283-2288.
8. Fournier B, Häring S, Kaye AM, Sömjen D. 1996. Stimulation of creatine kinase specific activity in human osteoblast and endometrial cells by estrogens and antiestrogens and its modulation by calciotropic hormones. J Endocrinology 150:275-285.
9. Gitelman HJ. 1967. An improved automated procedure for the determination of calcium in biological specimens. Anal Biochem 18:521-531.
10. Harris SA, Tau KR, Turner RT, Spelsberg TC. 1996. Estrogen and progestins. In: Bilezikian JP, Raitz LG, Rodan GA, editors. Principles of bone biology. San Diego: The Academic Press. p 507-520.
11. Härkönen PL, Qu Q, Dahllund JC, Laine A, Hemminki K, Kangas L, Väänänen HK. 1996. FC1271a is a novel tissue-specific antiestrogen with bone-sparing effect. 10th International Congress of Endocrinology Vol I:P1.256.
12. Jordan VC, Phelps E, Lindgren JU. 1987. Effects of antiestrogens on bone in castrated and intact female rats. Breast Cancer Res Treat 10:31-35.
13. Keeting PE, Scott RE, Colvard DS, Han IK, Spelsberg TC, Riggs BL. 1991. Lack of a direct effect of estrogen on proliferation and differentiation of normal human osteoblast-like cells. J Bone Miner Res 6:297-304.
14. Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-Å. 1996. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930.
15. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J-Å. 1997. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138: 863-870.
16. Larry JB, Sato M, Rowley ER, Magee DE, Bekele A, Williams DC, Cullinan GJ, Bendele R, Kauffman RF, Bensch WR, Frolik CA, Termine JD, Bryant HU. 1994. Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest 93:63-69.
17. Lowry OH, Roberts NR, Wu M, Hixton WS, Crawford EJ. 1954. The quantitative histochemistry of brain. II. Enzyme measurements. J Biol Chem 207:19-37.
18. Mosselman S, Polman J, Dijkema R. 1996. ERβ: Identification and characterization of a novel human estrogen receptor. FEBS Lett 392:49-53.
19. Nuttall ME, Bradbeer JN, Stroup GB, Nadeau DP, Huffman SJ, Zhao H, Rehm S, Gowen M. 1998. Idoxifene: A novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats. Endocrinology 139:5224-5234.
20. Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T. 1997. Expression of estrogen receptor β in rat bone. Endocrinology 138:4509-4512.
21. Paech K, Webb P, Kuiper GGJM, Nilsson S, Gustafsson J-Å, Kushner PJ, Scanlan TS. 1997. Defferential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277:1508-1510.
22. Parfitt AM. 1979. Quantam concept of bone remodeling and turnover: Implications for the pathogenesis of osteoporosis. Calc Tissue Int 28:1-5.
23. Qu Q, Perälä-Heape M, Kapanen A, Dahllund J, Salo J, Väänänen HK, Härkönen P. 1998. Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture. Bone 22:201-209.
24. Riggs BL, Jowsey J, Goldsmith RS, Kelly PJ, Hoffman DL, Arnaud CD. 1972. Short-and long-term effects of oestrogen and synthetic anabolic hormone in postmenopausal osteoporosis. J Clin Invest 51:1659-1663.
25. Riggs BL. 1991. Overview of osteoporosis. West J Med 154:63-77.
26. Riggs BL, Melton III LJ. 1992. The prevention and treatment of osteoporosis. N Engl J Med 327:620-627.
27. Robinson JA, Harris SA, Riggs BL, Spelsberg TC. 1997. Estrogen regulation of human osteoblastic cell proliferation and differentiation. Endocrinology 138:2919-2927.
28. Sato M, McClintock C, Kim J, Turner CH, Bryant HU, Magee D, Slemenda CW. 1994. Dual-energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats. J Bone Miner Res 9:715-724.
29. Scheven BAA, Damen CA, Hamilton NJ, Verhaar HJJ, Duursma SA. 1992. Stimulatory effects of estrogen and progesterone on proliferation and differentiation of normal human osteoblast-like cells in vitro. Biochem Biophys Res Commun 186:54-60.
30. Takano-Yamamoto T, Rodan GA. 1990. Direct effects of 17β-estradiol on trabecular bone in ovariectomized rats. Proc Natl Acad Sci USA 87:2172-2176.
31. Takeuchi M, Tokin M, Nagata K. 1995. Tamoxifen directly stimulates the mineralization of human osteoblast-like osteosarcoma cells through a pathway independent of estrogen response element. Biochem Biophys Res Commun 210:295-301.
32. Tremblay GB, Tremblay A, Copeland NG, Gilbert DJ, Jenkins NA, Labrie F, Giguere V. 1997. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor β. Mol Endocrinol 11:353-365.
33. Turner CH. 1991. Do estrogens increase bone formation? Bone 12:305-306.
34. Turner CH, Sato M, Bryant HU. 1994. Raloxifene preserves bone strength and bone mass in ovariectomized rats. Endocrinology 135:2001-2005.
35. Turner RT, Wakley GK, Hannon KS, Bell NH. 1987. Tamoxifen prevents the skeletal effects of ovarian deficiency in rats. J Bone Miner Res 2:449-456.
36. Turner RT, Wakley GK, Hannon KS, Bell NH. 1988. Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats. Endocrinology 122:46-50.
37. Von Kossa J. 1901. Uber die im organismus kunztlich erzeugen Verkalkungen. Beitr Anat 29:163.
38. Watts CKW, Parker MG, King RJB. 1989. Stable transfection of the oestrogen receptor gene into a human osteosarcoma cell line. J Steroid Biochem 34:483-490.
39. Yang NN, Venugopalan M, Hardikar S, Glasebrook A. 1996a. Identification of an estrogen response element activated by metabolites of 17 beta-estradiol and raloxifene. Science 273:1222-1225.
40. Yang NN, Bryant HU, Hardikar S, Sato M, Galvin RJ, Glasebrook AL, Termine JD. 1996b. Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: A potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology 137:2075-2084.